DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Abstract:

The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

Authors:

D Durocher, SP Jackson

Journal:

Curr Opin Cell Biol

Citation info:

13(2):225-231

Publication date:

1st Apr 2001

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