DNA-PK activation by ionizing radiation-induced DNA single-strand breaks.

Abstract:

PURPOSE: To assess the ability of 60Co gamma-radiation-induced plasmid DNA single-strand breaks (gamma-ssb) to activate the DNA-dependent protein kinase (DNA-PK) in vitro. MATERIALS AND METHODS: Plasmid DNA was gamma-irradiated under aerobic conditions to yield 0-6 gamma-ssb and

Authors:

MA Plumb, GC Smith, SM Cunniffe, SP Jackson, P O'Neill

Journal:

Int J Radiat Biol

Citation info:

75(5):553-561

Publication date:

1st May 1999

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