DNA end-joining: from yeast to man.

Abstract:

DNA non-homologous end-joining (NHEJ) is a crucial process that has been conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent work has identified additional proteins involved in this pathway, providing insights into the mechanism of NHEJ and revealing exciting links with the control of transcription, telomere length and chromatin structure.

Authors:

SE Critchlow, SP Jackson

Journal:

Trends Biochem Sci

Citation info:

23(10):394-398

Publication date:

1st Oct 1998

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