DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

Abstract:

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

Authors:

SP Jackson, PA Jeggo

Journal:

Trends Biochem Sci

Citation info:

20(10):412-415

Publication date:

1st Oct 1995

Full text

DOI