Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.
- Abstract:
- Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell-free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole-genome sequencing (sWGS, at a coverage of
- Authors:
- F Mouliere, R Mair, D Chandrananda, F Marass, CG Smith, J Su, J Morris, C Watts, KM Brindle, N Rosenfeld
- Journal:
- EMBO Mol Med
- Citation info:
- 10(12)
- Publication date:
- 1st Dec 2018
- Full text
- DOI