Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.
- Abstract:
- The integration of genomic and transcriptomic profiles of 2000 breast tumours from the METABRIC [Molecular Taxonomy of Breast Cancer International Consortium] cohort revealed ten subtypes, termed integrative clusters (IntClust/s), characterised by distinct genomic drivers. Central histopathology (N = 1643) review was undertaken to explore the relationship between these ten molecular subtypes and traditional clinicopathological features. IntClust subtypes were significantly associated with histological type, tumour grade, receptor status, and lymphocytic infiltration (p
- Authors:
- A Mukherjee, R Russell, S-F Chin, B Liu, OM Rueda, HR Ali, G Turashvili, B Mahler-Araujo, IO Ellis, S Aparicio, C Caldas, E Provenzano
- Journal:
- NPJ Breast Cancer
- Citation info:
- 4:5
- Publication date:
- 1st Aug 2018
- Full text
- DOI