Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer.
- Abstract:
- BACKGROUND: There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for their H&E visual evaluation has been validated in breast cancer. METHODS: We sought to investigate the prognostic significance of TILs in a study of 953 invasive epithelial ovarian cancer tumour samples, both primary and metastatic, from 707 patients from the prospective population-based SEARCH study. TILs were analysed using a standardised method based on H&E staining producing a percentage score for stromal and intratumoral compartments. We used Cox regression to estimate hazard ratios of the association between TILs and survival. RESULTS: The extent of stromal and intra-tumoral TILs were correlated in the primary tumours (n = 679, Spearman's rank correlation = 0.60, P
- Authors:
- FR James, M Jiminez-Linan, J Alsop, M Mack, H Song, JD Brenton, PDP Pharoah, HR Ali
- Journal:
- BMC Cancer
- Citation info:
- 17(1):657
- Publication date:
- 20th Sep 2017
- Full text
- DOI