Association analysis identifies 65 new breast cancer risk loci.

Abstract:

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P 

Authors:

K Michailidou, S Lindström, J Dennis, J Beesley, S Hui, S Kar, A Lemaçon, P Soucy, D Glubb, A Rostamianfar, MK Bolla, Q Wang, J Tyrer, E Dicks, A Lee, Z Wang, J Allen, R Keeman, U Eilber, JD French, X Qing Chen, L Fachal, K McCue, AE McCart Reed, M Ghoussaini, JS Carroll, X Jiang, H Finucane, M Adams, MA Adank, H Ahsan, K Aittomäki, H Anton-Culver, NN Antonenkova, V Arndt, KJ Aronson, B Arun, PL Auer, F Bacot, M Barrdahl, C Baynes, MW Beckmann, S Behrens, J Benitez, M Bermisheva, L Bernstein, C Blomqvist, NV Bogdanova, SE Bojesen, B Bonanni, A-L Børresen-Dale, JS Brand, H Brauch, P Brennan, H Brenner, L Brinton, P Broberg, IW Brock, A Broeks, A Brooks-Wilson, SY Brucker, T Brüning, B Burwinkel, K Butterbach, Q Cai, H Cai, T Caldés, F Canzian, A Carracedo, BD Carter, JE Castelao, TL Chan, T-Y David Cheng, K Seng Chia, J-Y Choi, H Christiansen, CL Clarke, NBCS Collaborators, M Collée, DM Conroy, E Cordina-Duverger, S Cornelissen, DG Cox, A Cox, SS Cross, JM Cunningham, K Czene, MB Daly, P Devilee, KF Doheny, T Dörk, I Dos-Santos-Silva, M Dumont, L Durcan, M Dwek, DM Eccles, AB Ekici, AH Eliassen, C Ellberg, M Elvira, C Engel, M Eriksson, PA Fasching, J Figueroa, D Flesch-Janys, O Fletcher, H Flyger, L Fritschi, V Gaborieau, M Gabrielson, M Gago-Dominguez, Y-T Gao, SM Gapstur, JA García-Sáenz, MM Gaudet, V Georgoulias, GG Giles, G Glendon, MS Goldberg, DE Goldgar, A González-Neira, GI Grenaker Alnæs, M Grip, J Gronwald, A Grundy, P Guénel, L Haeberle, E Hahnen, CA Haiman, N Håkansson, U Hamann, N Hamel, S Hankinson, P Harrington, SN Hart, JM Hartikainen, M Hartman, A Hein, J Heyworth, B Hicks, P Hillemanns, DN Ho, A Hollestelle, MJ Hooning, RN Hoover, JL Hopper, M-F Hou, C-N Hsiung, G Huang, K Humphreys, J Ishiguro, H Ito, M Iwasaki, H Iwata, A Jakubowska, W Janni, EM John, N Johnson, K Jones, M Jones, A Jukkola-Vuorinen, R Kaaks, M Kabisch, K Kaczmarek, D Kang, Y Kasuga, MJ Kerin, S Khan, E Khusnutdinova, JI Kiiski, S-W Kim, JA Knight, V-M Kosma, VN Kristensen, U Krüger, A Kwong, D Lambrechts, L Le Marchand, E Lee, MH Lee, JW Lee, C Neng Lee, F Lejbkowicz, J Li, J Lilyquist, A Lindblom, J Lissowska, W-Y Lo, S Loibl, J Long, A Lophatananon, J Lubinski, C Luccarini, MP Lux, ESK Ma, RJ MacInnis, T Maishman, E Makalic, KE Malone, IM Kostovska, A Mannermaa, S Manoukian, JE Manson, S Margolin, S Mariapun, ME Martinez, K Matsuo, D Mavroudis, J McKay, C McLean, H Meijers-Heijboer, A Meindl, P Menéndez, U Menon, J Meyer, H Miao, N Miller, NAM Taib, K Muir, AM Mulligan, C Mulot, SL Neuhausen, H Nevanlinna, P Neven, SF Nielsen, D-Y Noh, BG Nordestgaard, A Norman, OI Olopade, JE Olson, H Olsson, C Olswold, N Orr, VS Pankratz, SK Park, T-W Park-Simon, R Lloyd, JIA Perez, P Peterlongo, J Peto, K-A Phillips, M Pinchev, D Plaseska-Karanfilska, R Prentice, N Presneau, D Prokofyeva, E Pugh, K Pylkäs, B Rack, P Radice, N Rahman, G Rennert, HS Rennert, V Rhenius, A Romero, J Romm, KJ Ruddy, T Rüdiger, A Rudolph, M Ruebner, EJT Rutgers, E Saloustros, DP Sandler, S Sangrajrang, EJ Sawyer, DF Schmidt, RK Schmutzler, A Schneeweiss, MJ Schoemaker, F Schumacher, P Schürmann, RJ Scott, C Scott, S Seal, C Seynaeve, M Shah, P Sharma, C-Y Shen, G Sheng, ME Sherman, MJ Shrubsole, X-O Shu, A Smeets, C Sohn, MC Southey, JJ Spinelli, C Stegmaier, S Stewart-Brown, J Stone, DO Stram, H Surowy, A Swerdlow, R Tamimi, JA Taylor, M Tengström, SH Teo, M Beth Terry, DC Tessier, S Thanasitthichai, K Thöne, RAEM Tollenaar, I Tomlinson, L Tong, D Torres, T Truong, C-C Tseng, S Tsugane, H-U Ulmer, G Ursin, M Untch, C Vachon, CJ van Asperen, D Van Den Berg, AMW van den Ouweland, L van der Kolk, RB van der Luijt, D Vincent, J Vollenweider, Q Waisfisz, S Wang-Gohrke, CR Weinberg, C Wendt, AS Whittemore, H Wildiers, W Willett, R Winqvist, A Wolk, AH Wu, L Xia, T Yamaji, XR Yang, C Har Yip, K-Y Yoo, J-C Yu, W Zheng, Y Zheng, B Zhu, A Ziogas, E Ziv, ABCTB Investigators, ConFab/AOCS Investigators, SR Lakhani, AC Antoniou, A Droit, IL Andrulis, CI Amos, FJ Couch, PDP Pharoah, J Chang-Claude, P Hall, DJ Hunter, RL Milne, M García-Closas, MK Schmidt, SJ Chanock, AM Dunning, SL Edwards, GD Bader, G Chenevix-Trench, J Simard, P Kraft, DF Easton

Journal:

Nature

Citation info:

551(7678):92-94

Publication date:

2nd Nov 2017

Full text

DOI