An optoacoustic imaging feature set to characterise blood vessels surrounding benign and malignant breast lesions.
- Abstract:
- Combining optoacoustic (OA) imaging with ultrasound (US) enables visualisation of functional blood vasculature in breast lesions by OA to be overlaid with the morphological information of US. Here, we develop a simple OA feature set to differentiate benign and malignant breast lesions. 94 female patients with benign, indeterminate or suspicious lesions were recruited and underwent OA-US. An OA-US imaging feature set was developed using images from the first 38 patients, which contained 14 malignant and 8 benign solid lesions. Two independent radiologists blindly scored the OA-US images of a further 56 patients, which included 31 malignant and 13 benign solid lesions, with a sensitivity of 96.8% and specificity of 84.6%. Our findings indicate that OA-US can reveal vascular patterns of breast lesions that indicate malignancy using a simple feature set based on single wavelength OA data, which is therefore amenable to application in low resource settings for breast cancer management.
- Authors:
- O Abeyakoon, R Woitek, MG Wallis, PL Moyle, S Morscher, N Dahlhaus, SJ Ford, NC Burton, R Manavaki, IA Mendichovszky, J Joseph, I Quiros-Gonzalez, SE Bohndiek, FJ Gilbert
- Journal:
- Photoacoustics
- Citation info:
- 27:100383
- Publication date:
- 1st Sep 2022
- Full text
- DOI