An active DNA-based nanoprobe for photoacoustic pH imaging.

Abstract:

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

Authors:

KN Baumann, AC Fux, J Joseph, SE Bohndiek, S Hernández-Ainsa

Journal:

Chemical Communications

Citation info:

54(10176)

Publication date:

23rd Aug 2018

Full text

DOI