1. Home
  2. Publications
  3. A single type of progenitor cell...

A single type of progenitor cell maintains normal epidermis.

Abstract:
According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.
Authors:
E Clayton, DP Doupé, AM Klein, DJ Winton, BD Simons, PH Jones
Journal:
Nature
Citation info:
446(7132):185-189
Publication date:
8th Mar 2007
Full text
DOI