A PNA4 quadruplex.

Abstract:

A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers the gross structural features of a DNA quadruplex, but without the negatively charged backbone.

Authors:

Y Krishnan-Ghosh, E Stephens, S Balasubramanian

Journal:

J Am Chem Soc

Citation info:

126(19):5944-5945

Publication date:

19th May 2004

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