A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth.
- Abstract:
- In this issue of Cancer Discovery, Auciello and colleagues find that in the pancreatic cancer microenvironment activated fibroblasts secrete specific lipids that provide a source of biomass production and signaling molecules for cancer cells, fueling their proliferation and migration. Targeting of this stromal-tumor metabolic cross-talk impairs pancreatic cancer progression and represents a new potential therapeutic opportunity.See related article by Auciello et al., p. 617.
- Authors:
- G Biffi, DA Tuveson
- Journal:
- Cancer Discov
- Citation info:
- 9(5):578-580
- Publication date:
- 1st May 2019
- Full text
- DOI