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Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.

Authors:
E-pub date: 3 Feb 2026
Journal name: Nat Aging

MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors.

Authors: H Dogan, M Liptay, JS Barbosa, E Gogola, AA Duarte, JA Schmid, I Klebic, M ...
E-pub date: 1 Feb 2026
Journal name: Oncogene

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer.

Authors: F Puddu, A Johansson, A Modat, J Scotcher, R Sethi, S Yu, N Harding, M Hill...
E-pub date: 20 Jan 2026
Journal name: Commun Med (Lond)

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

Authors: A Watterson, G Picco, V Veninga, Y Samarakoon, CM Cattaneo, SF Vieira, E Ka...
E-pub date: 20 Jan 2026
Journal name: Cell Rep Med

Lung Metastases in Pancreatic Cancer: Timing Their First Breath.

Authors: G Mucciolo, G Biffi
E-pub date: 2 Jan 2026
Journal name: Cancer Res

Symptom-triggered testing detects early stage and low volume resectable advanced stage ovarian cancer.

Authors: FLA Kwong, C Kristunas, C Davenport, J Deeks, S Mallett, R Agarwal, S Kehoe...
E-pub date: 1 Jan 2026
Journal name: Int J Gynecol Cancer

Decay of driver mutations shapes the landscape of intestinal transformation.

Authors: FC Lourenço, ID Sadien, K Wong, S Adler, A Sawle, LS Santana, L Hazelwood,...
E-pub date: 1 Jan 2026
Journal name: Nature

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

Authors: M Schoof, T Zheng, M Sill, R Imle, A Cais, L Altendorf, A FĂĽrst, N Hofmann...
E-pub date: 1 Jan 2026
Journal name: Nat Genet