Improving early detection of cancer with hyperspectral endoscopy

The Bohndiek Group have developed advanced imaging technology to improve early detection of esophageal cancer in patients with Barrett’s oesophagus, offering a more detailed and accurate examination than current methods. 

Patients with Barrett’s oesophagus are at a higher risk of developing esophageal cancer and need regular endoscopic check-ups. Unfortunately, current methods often miss early signs of cancer, with up to 50% of cases going undiagnosed. 

The Bohndiek Group have developed new tools to address this issue. Instead of using only white light, their advanced technology uses the full colour spectrum of light to examine tissue and identify early signs of cancer. This technique, called hyperspectral imaging, captures many more details than regular imaging, which helps doctors see changes in the tissue that might indicate cancer. 

Using hyperspectral imaging in endoscopy can be challenging because it can cause image distortions. To fix this, the team has created a method to capture hyperspectral and white light images at the same time, allowing them to correct any distortions with computer software. 

In pilot studies at Addenbrooke’s Hospital in Cambridge and Oregon Health Sciences University in the USA, the team tested their technology by collecting data from suspicious areas and comparing it with confirmed diagnoses. The results showed that hyperspectral endoscopy is better at identifying early signs of cancer than the standard method, making it a promising tool for early detection. 

The team also developed a new colour filter technology for custom cameras, which improves the image quality even further. This innovative technology is now being tested in a clinical trial at Johns Hopkins University. They are also seeking approval for a larger clinical trial with the University of Manchester. 

Led by Professor Sarah Bohndiek, this innovative work aims to improve the early detection of cancer in the gastrointestinal tract. Incorporating advanced hyperspectral imaging into regular clinical practice can reduce the number of missed cancer cases and improve patient outcomes.