Group Leader

Research Group Home Page: 
Brindle Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis.

E-pub date: 30 Apr 2019

Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’.

E-pub date: 30 Apr 2019

Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

E-pub date: 28 Feb 2019

Challenges to curing primary brain tumours.

E-pub date: 31 Jan 2019

Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

E-pub date: 31 Dec 2018

Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

E-pub date: 31 Oct 2018

Enhanced detection of circulating tumor DNA by fragment size analysis.

E-pub date: 31 Oct 2018

Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

E-pub date: 31 Oct 2018

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

E-pub date: 31 Oct 2018

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates.

E-pub date: 30 Sep 2018

Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

E-pub date: 31 Aug 2018

Emerging Technologies to Image Tissue Metabolism.

E-pub date: 31 Aug 2018

Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites.

E-pub date: 31 Aug 2018

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.

E-pub date: 01 Aug 2018

Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma.

E-pub date: 30 Jun 2018

Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.

E-pub date: 01 Jun 2018

Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment.

E-pub date: 01 Jun 2018

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

E-pub date: 31 May 2018

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

E-pub date: 01 Apr 2018

Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

E-pub date: 31 Mar 2018

Dynamic 1 H imaging of hyperpolarized [1-13 C]lactate in vivo using a reverse INEPT experiment.

E-pub date: 01 Feb 2018

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

E-pub date: 01 Feb 2018

[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

E-pub date: 01 Jan 2018

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

E-pub date: 20 Dec 2017

Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

E-pub date: 15 Dec 2017

Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

E-pub date: 15 Nov 2017

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

E-pub date: 31 Aug 2017

Brain Tumor Imaging.

E-pub date: 20 Jul 2017

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

E-pub date: 08 Jun 2017

Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

E-pub date: 01 Jun 2017

Site-Selective Modification of Proteins with Oxetanes.

E-pub date: 11 May 2017

Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

E-pub date: 03 Feb 2017

Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.

E-pub date: 01 Feb 2017

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

E-pub date: 31 Jan 2017

The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

E-pub date: 31 Dec 2016

Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

E-pub date: 01 Nov 2016

Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

E-pub date: 21 Sep 2016

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

E-pub date: 31 Aug 2016

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.

E-pub date: 31 Aug 2016

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

E-pub date: 31 Aug 2016

Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

E-pub date: 01 Aug 2016

Detection of colorectal dysplasia using fluorescently labelled lectins.

E-pub date: 13 Apr 2016

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

E-pub date: 01 Apr 2016

Development of Timd2 as a reporter gene for MRI.

E-pub date: 01 Apr 2016

Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

E-pub date: 01 Apr 2016

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

E-pub date: 31 Mar 2016

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

E-pub date: 15 Mar 2016

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.

E-pub date: 31 Dec 2015

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

E-pub date: 01 Oct 2015

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.

E-pub date: 31 Aug 2015

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

E-pub date: 07 Jul 2015

(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

E-pub date: 31 May 2015

Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

E-pub date: 27 May 2015

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

E-pub date: 01 Apr 2015

Imaging tumor metabolism using positron emission tomography.

E-pub date: 31 Mar 2015

CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.

E-pub date: 01 Nov 2014

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin.

E-pub date: 31 Oct 2014

Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

E-pub date: 31 Jul 2014

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

E-pub date: 28 Apr 2014

Towards a successful clinical implementation of fluorescence-guided surgery.

E-pub date: 01 Apr 2014

Versatile and enhanced tumour modelling in mice via somatic cell transduction.

E-pub date: 31 Mar 2014

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

E-pub date: 31 Mar 2014

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

E-pub date: 31 Mar 2014

Clinical proton MR spectroscopy in central nervous system disorders.

E-pub date: 01 Mar 2014

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

E-pub date: 31 Jan 2014

Imaging cell death.

E-pub date: 31 Jan 2014

Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

E-pub date: 31 Jan 2014

Dual-modality gene reporter for in vivo imaging.

E-pub date: 07 Jan 2014

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

E-pub date: 31 Dec 2013

Dual-sugar imaging using isonitrile and azido-based click chemistries.

E-pub date: 14 Nov 2013

Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

E-pub date: 01 Nov 2013

Imaging mouse cancer models in vivo using reporter transgenes.

E-pub date: 01 Aug 2013

Imaging cell surface glycosylation in vivo using “double click” chemistry.

E-pub date: 19 Jun 2013

Metabolic glycan imaging by isonitrile-tetrazine click chemistry.

E-pub date: 17 Jun 2013

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013

Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation.

E-pub date: 01 Sep 2012

What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

E-pub date: 31 Aug 2012

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

E-pub date: 14 Aug 2012

Direct enhancement of nuclear singlet order by dynamic nuclear polarization.

E-pub date: 09 May 2012

Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.

E-pub date: 14 Mar 2012

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

E-pub date: 15 Feb 2012

Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett’s esophagus.

E-pub date: 15 Jan 2012

Exploring isonitrile-based click chemistry for ligation with biomolecules.

E-pub date: 07 Nov 2011

Imaging pH with hyperpolarized 13C.

E-pub date: 31 Oct 2011

Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

E-pub date: 01 Sep 2011

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Aug 2011

Imaging sialylated tumor cell glycans in vivo.

E-pub date: 31 Aug 2011

Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

E-pub date: 03 Aug 2011

Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.

E-pub date: 31 Jul 2011

Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.

E-pub date: 15 Jul 2011

(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent.

E-pub date: 07 Jul 2011

Mitochondrial dysfunction in patients with primary congenital insulin resistance.

E-pub date: 01 Jun 2011

Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

E-pub date: 31 May 2011

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

E-pub date: 20 May 2011

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

E-pub date: 01 Feb 2011

Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.

E-pub date: 01 Feb 2011

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

E-pub date: 01 Feb 2011

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Dec 2010

Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Oct 2010

Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate.

E-pub date: 26 Oct 2010

Imaging and ‘omic’ methods for the molecular diagnosis of cancer.

E-pub date: 31 May 2010

Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death.

E-pub date: 19 May 2010

Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma.

E-pub date: 01 Apr 2010

Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.

E-pub date: 24 Nov 2009

A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment.

E-pub date: 01 Jun 2009

Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent.

E-pub date: 31 May 2009

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.

E-pub date: 31 Aug 2008

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

E-pub date: 12 Jun 2008

Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

E-pub date: 31 Mar 2008

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

E-pub date: 01 Nov 2007

SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model.

E-pub date: 01 Nov 2007

H NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat.

E-pub date: 31 Jul 2007

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

E-pub date: 31 May 2007

Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling.

E-pub date: 01 Apr 2007

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

E-pub date: 01 Jun 2005

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

E-pub date: 01 Jun 2002

Tissue engineering of meniscal cartilage using perfusion culture.

E-pub date: 01 Jun 2002

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria.

E-pub date: 31 Dec 2001

Potent anti-metastatic activity of combretastatin-A4.

E-pub date: 01 Oct 2001

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast.

E-pub date: 31 May 2001

Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain.

E-pub date: 30 Nov 1999

Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates.

E-pub date: 31 Aug 1999

Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells.

E-pub date: 30 Jun 1999

Mitochondrial citrate synthase is immobilized in vivo.

E-pub date: 31 Jan 1999

Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status.

E-pub date: 01 Jun 1998

31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae.

E-pub date: 31 May 1996

Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.

E-pub date: 31 May 1995

Probing the properties of enzymes in vivo using NMR.

E-pub date: 01 May 1995

Estimation of the intracellular free ADP concentration by 19F NMR studies of fluorine-labeled yeast phosphoglycerate kinase in vivo.

E-pub date: 30 Apr 1993

A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells.

E-pub date: 31 Mar 1993

Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths.

E-pub date: 30 Sep 1992

Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.

E-pub date: 30 Apr 1992

Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR.

E-pub date: 31 Mar 1992

A combined n.m.r. and molecular biological approach to studying enzymes in vivo.

E-pub date: 01 Nov 1991

31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.

E-pub date: 31 Jan 1990

31P NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo.

E-pub date: 30 Apr 1989

Determination of buffering capacity of rat myocardium during ischemia.

E-pub date: 31 Jul 1988

31P NMR magnetization-transfer measurements of flux between inorganic phosphate and adenosine 5′-triphosphate in yeast cells genetically modified to overproduce phosphoglycerate kinase.

E-pub date: 31 Jul 1988

31P-NMR saturation transfer studies of aerobic Escherichia coli cells.

E-pub date: 31 Mar 1988

31P NMR measurements of myocardial pH in vivo.

E-pub date: 31 Jan 1988

31P-NMR saturation transfer measurements of exchange between Pi and ATP in the reactions catalysed by glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in vitro.

E-pub date: 31 Mar 1987

A 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte.

E-pub date: 30 Jun 1986

Measurements of exchange in the reaction catalysed by creatine kinase using 14C and 15N isotope labels and the NMR technique of saturation transfer.

E-pub date: 31 May 1985

A multinuclear NMR study of 2,3-bisphosphoglycerate metabolism in the human erythrocyte.

E-pub date: 31 Aug 1984

The inhibition of erythrocyte glyceraldehyde-3-phosphate dehydrogenase. In situ PMR studies.

E-pub date: 31 May 1984

A comparison of 31P-NMR saturation transfer and isotope-exchange measurements of creatine kinase kinetics in vitro.

E-pub date: 31 Mar 1984

Proton NMR measurements of hydrogen exchange at the C-3 position of 3-hydroxybutyrate in suspensions of rat liver mitochondria.

E-pub date: 31 Oct 1983

Centrifugal analysis of undiluted packed human erythrocyte lysates. Studies of the association of glyceraldehyde-phosphate dehydrogenase with the membrane fraction.

E-pub date: 30 Jun 1983

A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte.

E-pub date: 30 Nov 1982

Observation of carbon labelling in cell metabolites using proton spin echo NMR.

E-pub date: 30 Nov 1982

Spin ECHO proton NMR studies of the metabolism of malate and fumarate in human erythrocytes. Dependence on free NAD levels.

E-pub date: 30 Sep 1982

A 1H n.m.r. study of isotope exchange catalysed by glycolytic enzymes in the human erythrocyte.

E-pub date: 28 Feb 1982

A p.m.r. isotope-exchange method for studying the kinetic properties of dehydrogenases in intact cells.

E-pub date: 28 Feb 1982

Studies of lactate dehydrogenase in the purified state and in intact erythrocytes.

E-pub date: 28 Feb 1982

Studies of pyruvate-water isotope exchange catalysed by erythrocytes and proteins.

E-pub date: 31 Jan 1981

1H/2H isotope exchange studies in intact erythrocytes.

E-pub date: 01 Oct 1980

Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport.

E-pub date: 31 Mar 1979

Show all
Research Integrity Conflict of Interest Disclosure: 
Last revised: 
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
MedImmune No Yes No No No No No No
MedImmune Yes Yes No No No No No No
Astra Zeneca Yes Yes No No No No No No
Disclosure guidelines