Kevin Brindle

Group Leader

Research Group Home Page:: Brindle Group

Work address:: Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Publications:: Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis.

E-pub date: 30 Apr 2019; Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’.

E-pub date: 30 Apr 2019; Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

E-pub date: 28 Feb 2019; Challenges to curing primary brain tumours.

E-pub date: 31 Jan 2019; Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

E-pub date: 31 Dec 2018; Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

E-pub date: 31 Oct 2018; Enhanced detection of circulating tumor DNA by fragment size analysis.

E-pub date: 31 Oct 2018; Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

E-pub date: 31 Oct 2018; Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

E-pub date: 31 Oct 2018; Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates.

E-pub date: 30 Sep 2018; Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

E-pub date: 31 Aug 2018; Emerging Technologies to Image Tissue Metabolism.

E-pub date: 31 Aug 2018; Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites.

E-pub date: 31 Aug 2018; Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.

E-pub date: 01 Aug 2018; Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma.

E-pub date: 30 Jun 2018; Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.

E-pub date: 01 Jun 2018; Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment.

E-pub date: 01 Jun 2018; Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

E-pub date: 31 May 2018; Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

E-pub date: 01 Apr 2018; Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

E-pub date: 31 Mar 2018; Dynamic 1 H imaging of hyperpolarized [1-13 C]lactate in vivo using a reverse INEPT experiment.

E-pub date: 01 Feb 2018; A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

E-pub date: 01 Feb 2018; [18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

E-pub date: 01 Jan 2018; Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

E-pub date: 20 Dec 2017; Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

E-pub date: 15 Dec 2017; Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

E-pub date: 15 Nov 2017; Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

E-pub date: 31 Aug 2017; Brain Tumor Imaging.

E-pub date: 20 Jul 2017; 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

E-pub date: 08 Jun 2017; Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

E-pub date: 01 Jun 2017; Site-Selective Modification of Proteins with Oxetanes.

E-pub date: 11 May 2017; Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017; Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

E-pub date: 03 Feb 2017; Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.

E-pub date: 01 Feb 2017; MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

E-pub date: 31 Jan 2017; The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

E-pub date: 31 Dec 2016; Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

E-pub date: 01 Nov 2016; Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

E-pub date: 21 Sep 2016; Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

E-pub date: 31 Aug 2016; (13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.

E-pub date: 31 Aug 2016; Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

E-pub date: 31 Aug 2016; Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

E-pub date: 01 Aug 2016; Detection of colorectal dysplasia using fluorescently labelled lectins.

E-pub date: 13 Apr 2016; A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

E-pub date: 01 Apr 2016; Development of Timd2 as a reporter gene for MRI.

E-pub date: 01 Apr 2016; Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

E-pub date: 01 Apr 2016; MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

E-pub date: 31 Mar 2016; 31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

E-pub date: 15 Mar 2016; Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016; Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016; Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.

E-pub date: 31 Dec 2015; Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

E-pub date: 01 Oct 2015; The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.

E-pub date: 31 Aug 2015; Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

E-pub date: 07 Jul 2015; (13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

E-pub date: 31 May 2015; Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

E-pub date: 27 May 2015; Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

E-pub date: 01 Apr 2015; Imaging tumor metabolism using positron emission tomography.

E-pub date: 31 Mar 2015; CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.

E-pub date: 01 Nov 2014; Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin.

E-pub date: 31 Oct 2014; Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

E-pub date: 31 Jul 2014; Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014; Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

E-pub date: 28 Apr 2014; Towards a successful clinical implementation of fluorescence-guided surgery.

E-pub date: 01 Apr 2014; Versatile and enhanced tumour modelling in mice via somatic cell transduction.

E-pub date: 31 Mar 2014; In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

E-pub date: 31 Mar 2014; Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

E-pub date: 31 Mar 2014; Clinical proton MR spectroscopy in central nervous system disorders.

E-pub date: 01 Mar 2014; Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

E-pub date: 31 Jan 2014; Imaging cell death.

E-pub date: 31 Jan 2014; Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

E-pub date: 31 Jan 2014; Dual-modality gene reporter for in vivo imaging.

E-pub date: 07 Jan 2014; Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

E-pub date: 31 Dec 2013; Dual-sugar imaging using isonitrile and azido-based click chemistries.

E-pub date: 14 Nov 2013; Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

E-pub date: 01 Nov 2013; Imaging mouse cancer models in vivo using reporter transgenes.

E-pub date: 01 Aug 2013; Imaging cell surface glycosylation in vivo using “double click” chemistry.

E-pub date: 19 Jun 2013; Metabolic glycan imaging by isonitrile-tetrazine click chemistry.

E-pub date: 17 Jun 2013; Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013; Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation.

E-pub date: 01 Sep 2012; What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

E-pub date: 31 Aug 2012; Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

E-pub date: 14 Aug 2012; Direct enhancement of nuclear singlet order by dynamic nuclear polarization.

E-pub date: 09 May 2012; Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.

E-pub date: 14 Mar 2012; Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

E-pub date: 15 Feb 2012; Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett’s esophagus.

E-pub date: 15 Jan 2012; Exploring isonitrile-based click chemistry for ligation with biomolecules.

E-pub date: 07 Nov 2011; Imaging pH with hyperpolarized 13C.

E-pub date: 31 Oct 2011; Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

E-pub date: 01 Sep 2011; Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Aug 2011; Imaging sialylated tumor cell glycans in vivo.

E-pub date: 31 Aug 2011; Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

E-pub date: 03 Aug 2011; Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.

E-pub date: 31 Jul 2011; Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.

E-pub date: 15 Jul 2011; (E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent.

E-pub date: 07 Jul 2011; Mitochondrial dysfunction in patients with primary congenital insulin resistance.

E-pub date: 01 Jun 2011; Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

E-pub date: 31 May 2011; The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

E-pub date: 20 May 2011; Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

E-pub date: 01 Feb 2011; Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.

E-pub date: 01 Feb 2011; Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

E-pub date: 01 Feb 2011; Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Dec 2010; Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Oct 2010; Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate.

E-pub date: 26 Oct 2010; Imaging and ‘omic’ methods for the molecular diagnosis of cancer.

E-pub date: 31 May 2010; Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death.

E-pub date: 19 May 2010; Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma.

E-pub date: 01 Apr 2010; Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.

E-pub date: 24 Nov 2009; A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment.

E-pub date: 01 Jun 2009; Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent.

E-pub date: 31 May 2009; 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.

E-pub date: 31 Aug 2008; Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

E-pub date: 12 Jun 2008; Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

E-pub date: 31 Mar 2008; New approaches for imaging tumour responses to treatment.

E-pub date: 01 Feb 2008; Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

E-pub date: 01 Nov 2007; SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model.

E-pub date: 01 Nov 2007; H NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat.

E-pub date: 31 Jul 2007; A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

E-pub date: 31 May 2007; Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling.

E-pub date: 01 Apr 2007; The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

E-pub date: 01 Jun 2005; Tumor cell-derived nitric oxide is involved in the immune-rejection of an immunogenic murine lymphoma.

E-pub date: 31 Dec 2003; Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy.

E-pub date: 01 Aug 2002; A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

E-pub date: 01 Jun 2002; Tissue engineering of meniscal cartilage using perfusion culture.

E-pub date: 01 Jun 2002; Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS.

E-pub date: 01 Apr 2002; Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria.

E-pub date: 31 Dec 2001; Measurement of bioreactor perfusion using dynamic contrast agent-enhanced magnetic resonance imaging.

E-pub date: 30 Nov 2001; Potent anti-metastatic activity of combretastatin-A4.

E-pub date: 01 Oct 2001; A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast.

E-pub date: 31 May 2001; Diffusion weighted imaging and magnetic resonance spectroscopy in a low flow ischaemia model due to endothelin induced vasospasm.

E-pub date: 01 May 2000; Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain.

E-pub date: 30 Nov 1999; Mitochondrial proton leak and the uncoupling proteins.

E-pub date: 01 Oct 1999; Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates.

E-pub date: 31 Aug 1999; Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells.

E-pub date: 30 Jun 1999; The significance and mechanism of mitochondrial proton conductance.

E-pub date: 01 Jun 1999; Mitochondrial citrate synthase is immobilized in vivo.

E-pub date: 31 Jan 1999; Induction of apoptosis in two mammalian cell lines results in increased levels of fructose-1,6-bisphosphate and CDP-choline as determined by 31P MRS.

E-pub date: 01 Sep 1998; Investigating the performance of intensive mammalian cell bioreactor systems using magnetic resonance imaging and spectroscopy.

E-pub date: 01 Aug 1998; Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status.

E-pub date: 01 Jun 1998; 31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae.

E-pub date: 31 May 1996; 31P NMR measurements of the effects of unsaturated fatty acids on cellular phospholipid metabolism.

E-pub date: 01 Apr 1996; Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.

E-pub date: 31 May 1995; Probing the properties of enzymes in vivo using NMR.

E-pub date: 01 May 1995; Measurements of the growth and distribution of mammalian cells in a hollow-fiber bioreactor using nuclear magnetic resonance imaging.

E-pub date: 01 Jan 1994; Estimation of the intracellular free ADP concentration by 19F NMR studies of fluorine-labeled yeast phosphoglycerate kinase in vivo.

E-pub date: 30 Apr 1993; The appearance of neutral lipid signals in the 1H NMR spectra of a myeloma cell line correlates with the induced formation of cytoplasmic lipid droplets.

E-pub date: 01 Apr 1993; A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells.

E-pub date: 31 Mar 1993; Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths.

E-pub date: 30 Sep 1992; Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.

E-pub date: 30 Apr 1992; Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR.

E-pub date: 31 Mar 1992; A combined n.m.r. and molecular biological approach to studying enzymes in vivo.

E-pub date: 01 Nov 1991; 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.

E-pub date: 31 Jan 1990; Phospholipid bilayer contribution to 31P NMR spectra in vivo.

E-pub date: 01 Nov 1989; 31P NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo.

E-pub date: 30 Apr 1989; Determination of buffering capacity of rat myocardium during ischemia.

E-pub date: 31 Jul 1988; 31P NMR magnetization-transfer measurements of flux between inorganic phosphate and adenosine 5′-triphosphate in yeast cells genetically modified to overproduce phosphoglycerate kinase.

E-pub date: 31 Jul 1988; 31P-NMR saturation transfer studies of aerobic Escherichia coli cells.

E-pub date: 31 Mar 1988; 31P NMR measurements of myocardial pH in vivo.

E-pub date: 31 Jan 1988; NMR studies of kinetics in cells and tissues.

E-pub date: 01 May 1987; 31P-NMR saturation transfer measurements of exchange between Pi and ATP in the reactions catalysed by glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in vitro.

E-pub date: 31 Mar 1987; A 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte.

E-pub date: 30 Jun 1986; Measurements of exchange in the reaction catalysed by creatine kinase using 14C and 15N isotope labels and the NMR technique of saturation transfer.

E-pub date: 31 May 1985; A multinuclear NMR study of 2,3-bisphosphoglycerate metabolism in the human erythrocyte.

E-pub date: 31 Aug 1984; The inhibition of erythrocyte glyceraldehyde-3-phosphate dehydrogenase. In situ PMR studies.

E-pub date: 31 May 1984; A comparison of 31P-NMR saturation transfer and isotope-exchange measurements of creatine kinase kinetics in vitro.

E-pub date: 31 Mar 1984; Proton NMR measurements of hydrogen exchange at the C-3 position of 3-hydroxybutyrate in suspensions of rat liver mitochondria.

E-pub date: 31 Oct 1983; Centrifugal analysis of undiluted packed human erythrocyte lysates. Studies of the association of glyceraldehyde-phosphate dehydrogenase with the membrane fraction.

E-pub date: 30 Jun 1983; A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte.

E-pub date: 30 Nov 1982; Observation of carbon labelling in cell metabolites using proton spin echo NMR.

E-pub date: 30 Nov 1982; Spin ECHO proton NMR studies of the metabolism of malate and fumarate in human erythrocytes. Dependence on free NAD levels.

E-pub date: 30 Sep 1982; A 1H n.m.r. study of isotope exchange catalysed by glycolytic enzymes in the human erythrocyte.

E-pub date: 28 Feb 1982; A p.m.r. isotope-exchange method for studying the kinetic properties of dehydrogenases in intact cells.

E-pub date: 28 Feb 1982; Studies of lactate dehydrogenase in the purified state and in intact erythrocytes.

E-pub date: 28 Feb 1982; Studies of pyruvate-water isotope exchange catalysed by erythrocytes and proteins.

E-pub date: 31 Jan 1981; 1H/2H isotope exchange studies in intact erythrocytes.

E-pub date: 01 Oct 1980; Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport.

E-pub date: 31 Mar 1979; Show all Hide all

Research Integrity Conflict of Interest Disclosure:

Last revised:: 24/09/2018

Company	Active	Research funding	Ownership	Royalty payments	Commitment to carry out work for a fee	Ad hoc reimbursed work	Travel	Gifts/ other
MedImmune	No	Yes	No	No	No	No	No	No
MedImmune	Yes	Yes	No	No	No	No	No	No
Astra Zeneca	Yes	Yes	No	No	No	No	No	No

Disclosure guidelines

Kevin Brindle

Group Leader

Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis.

Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’.

Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Challenges to curing primary brain tumours.

Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

Enhanced detection of circulating tumor DNA by fragment size analysis.

Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates.

Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

Emerging Technologies to Image Tissue Metabolism.

Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites.

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.

Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma.

Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.

Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment.

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

Dynamic 1 H imaging of hyperpolarized [1-13 C]lactate in vivo using a reverse INEPT experiment.

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

Brain Tumor Imaging.

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

Site-Selective Modification of Proteins with Oxetanes.

Imaging biomarker roadmap for cancer studies.

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

Detection of colorectal dysplasia using fluorescently labelled lectins.

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

Development of Timd2 as a reporter gene for MRI.

Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

Imaging tumor metabolism using positron emission tomography.

CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin.

Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

Towards a successful clinical implementation of fluorescence-guided surgery.

Versatile and enhanced tumour modelling in mice via somatic cell transduction.

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

Clinical proton MR spectroscopy in central nervous system disorders.

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

Imaging cell death.

Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

Dual-modality gene reporter for in vivo imaging.

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

Dual-sugar imaging using isonitrile and azido-based click chemistries.

Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

Imaging mouse cancer models in vivo using reporter transgenes.

Imaging cell surface glycosylation in vivo using “double click” chemistry.

Metabolic glycan imaging by isonitrile-tetrazine click chemistry.