Group Leader

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis.

E-pub date: 30 Apr 2019


Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’.

E-pub date: 30 Apr 2019


Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

E-pub date: 28 Feb 2019


Challenges to curing primary brain tumours.

E-pub date: 31 Jan 2019


Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

E-pub date: 31 Dec 2018


Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

E-pub date: 31 Oct 2018


Enhanced detection of circulating tumor DNA by fragment size analysis.

E-pub date: 31 Oct 2018


Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

E-pub date: 31 Oct 2018


Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

E-pub date: 31 Oct 2018


Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates.

E-pub date: 30 Sep 2018


Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

E-pub date: 31 Aug 2018


Emerging Technologies to Image Tissue Metabolism.

E-pub date: 31 Aug 2018


Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites.

E-pub date: 31 Aug 2018


Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.

E-pub date: 01 Aug 2018


Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma.

E-pub date: 30 Jun 2018


Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.

E-pub date: 01 Jun 2018


Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment.

E-pub date: 01 Jun 2018


Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

E-pub date: 31 May 2018


Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

E-pub date: 01 Apr 2018


Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

E-pub date: 31 Mar 2018


Dynamic 1 H imaging of hyperpolarized [1-13 C]lactate in vivo using a reverse INEPT experiment.

E-pub date: 01 Feb 2018


A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

E-pub date: 01 Feb 2018


[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

E-pub date: 01 Jan 2018


Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

E-pub date: 20 Dec 2017


Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

E-pub date: 15 Dec 2017


Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

E-pub date: 15 Nov 2017


Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

E-pub date: 31 Aug 2017


Brain Tumor Imaging.

E-pub date: 20 Jul 2017


6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

E-pub date: 08 Jun 2017


Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

E-pub date: 01 Jun 2017


Site-Selective Modification of Proteins with Oxetanes.

E-pub date: 11 May 2017


Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017


Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

E-pub date: 03 Feb 2017


Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.

E-pub date: 01 Feb 2017


MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

E-pub date: 31 Jan 2017


The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

E-pub date: 31 Dec 2016


Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

E-pub date: 01 Nov 2016


Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

E-pub date: 21 Sep 2016


Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

E-pub date: 31 Aug 2016


(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.

E-pub date: 31 Aug 2016


Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

E-pub date: 31 Aug 2016


Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

E-pub date: 01 Aug 2016


Detection of colorectal dysplasia using fluorescently labelled lectins.

E-pub date: 13 Apr 2016


A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

E-pub date: 01 Apr 2016


Development of Timd2 as a reporter gene for MRI.

E-pub date: 01 Apr 2016


Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

E-pub date: 01 Apr 2016


MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

E-pub date: 31 Mar 2016


31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

E-pub date: 15 Mar 2016


Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016


Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

E-pub date: 22 Jan 2016


Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.

E-pub date: 31 Dec 2015


Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

E-pub date: 01 Oct 2015


The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.

E-pub date: 31 Aug 2015


Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

E-pub date: 07 Jul 2015


(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

E-pub date: 31 May 2015


Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

E-pub date: 27 May 2015


Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

E-pub date: 01 Apr 2015


Imaging tumor metabolism using positron emission tomography.

E-pub date: 31 Mar 2015


CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.

E-pub date: 01 Nov 2014


Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin.

E-pub date: 31 Oct 2014


Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

E-pub date: 31 Jul 2014


Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014


Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

E-pub date: 28 Apr 2014


Towards a successful clinical implementation of fluorescence-guided surgery.

E-pub date: 01 Apr 2014


Versatile and enhanced tumour modelling in mice via somatic cell transduction.

E-pub date: 31 Mar 2014


In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

E-pub date: 31 Mar 2014


Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

E-pub date: 31 Mar 2014


Clinical proton MR spectroscopy in central nervous system disorders.

E-pub date: 01 Mar 2014


Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

E-pub date: 31 Jan 2014


Imaging cell death.

E-pub date: 31 Jan 2014


Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

E-pub date: 31 Jan 2014


Dual-modality gene reporter for in vivo imaging.

E-pub date: 07 Jan 2014


Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

E-pub date: 31 Dec 2013


Dual-sugar imaging using isonitrile and azido-based click chemistries.

E-pub date: 14 Nov 2013


Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

E-pub date: 01 Nov 2013


Imaging mouse cancer models in vivo using reporter transgenes.

E-pub date: 01 Aug 2013


Imaging cell surface glycosylation in vivo using “double click” chemistry.

E-pub date: 19 Jun 2013


Metabolic glycan imaging by isonitrile-tetrazine click chemistry.

E-pub date: 17 Jun 2013


Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013


Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation.

E-pub date: 01 Sep 2012


What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

E-pub date: 31 Aug 2012


Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

E-pub date: 14 Aug 2012


Direct enhancement of nuclear singlet order by dynamic nuclear polarization.

E-pub date: 09 May 2012


Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.

E-pub date: 14 Mar 2012


Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

E-pub date: 15 Feb 2012


Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett’s esophagus.

E-pub date: 15 Jan 2012


Exploring isonitrile-based click chemistry for ligation with biomolecules.

E-pub date: 07 Nov 2011


Imaging pH with hyperpolarized 13C.

E-pub date: 31 Oct 2011


Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

E-pub date: 01 Sep 2011


Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Aug 2011


Imaging sialylated tumor cell glycans in vivo.

E-pub date: 31 Aug 2011


Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

E-pub date: 03 Aug 2011


Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.

E-pub date: 31 Jul 2011


Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.

E-pub date: 15 Jul 2011


(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent.

E-pub date: 07 Jul 2011


Mitochondrial dysfunction in patients with primary congenital insulin resistance.

E-pub date: 01 Jun 2011


Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

E-pub date: 31 May 2011


The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

E-pub date: 20 May 2011


Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

E-pub date: 01 Feb 2011


Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.

E-pub date: 01 Feb 2011


Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

E-pub date: 01 Feb 2011


Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Dec 2010


Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Oct 2010


Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate.

E-pub date: 26 Oct 2010


Imaging and ‘omic’ methods for the molecular diagnosis of cancer.

E-pub date: 31 May 2010


Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death.

E-pub date: 19 May 2010


Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma.

E-pub date: 01 Apr 2010


Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.

E-pub date: 24 Nov 2009


A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment.

E-pub date: 01 Jun 2009


Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent.

E-pub date: 31 May 2009


13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.

E-pub date: 31 Aug 2008


Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

E-pub date: 12 Jun 2008


Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

E-pub date: 31 Mar 2008


New approaches for imaging tumour responses to treatment.

E-pub date: 01 Feb 2008


Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

E-pub date: 01 Nov 2007


SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model.

E-pub date: 01 Nov 2007


H NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat.

E-pub date: 31 Jul 2007


A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

E-pub date: 31 May 2007


Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling.

E-pub date: 01 Apr 2007


The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

E-pub date: 01 Jun 2005


A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

E-pub date: 01 Jun 2002


Tissue engineering of meniscal cartilage using perfusion culture.

E-pub date: 01 Jun 2002


Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria.

E-pub date: 31 Dec 2001


Measurement of bioreactor perfusion using dynamic contrast agent-enhanced magnetic resonance imaging.

E-pub date: 30 Nov 2001


Potent anti-metastatic activity of combretastatin-A4.

E-pub date: 01 Oct 2001


A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast.

E-pub date: 31 May 2001


Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain.

E-pub date: 30 Nov 1999


Mitochondrial proton leak and the uncoupling proteins.

E-pub date: 01 Oct 1999


Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates.

E-pub date: 31 Aug 1999


Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells.

E-pub date: 30 Jun 1999


Mitochondrial citrate synthase is immobilized in vivo.

E-pub date: 31 Jan 1999


Induction of apoptosis in two mammalian cell lines results in increased levels of fructose-1,6-bisphosphate and CDP-choline as determined by 31P MRS.

E-pub date: 01 Sep 1998


Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status.

E-pub date: 01 Jun 1998


31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae.

E-pub date: 31 May 1996


31P NMR measurements of the effects of unsaturated fatty acids on cellular phospholipid metabolism.

E-pub date: 01 Apr 1996


Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.

E-pub date: 31 May 1995


Probing the properties of enzymes in vivo using NMR.

E-pub date: 01 May 1995


Estimation of the intracellular free ADP concentration by 19F NMR studies of fluorine-labeled yeast phosphoglycerate kinase in vivo.

E-pub date: 30 Apr 1993


The appearance of neutral lipid signals in the 1H NMR spectra of a myeloma cell line correlates with the induced formation of cytoplasmic lipid droplets.

E-pub date: 01 Apr 1993


A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells.

E-pub date: 31 Mar 1993


Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths.

E-pub date: 30 Sep 1992


Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.

E-pub date: 30 Apr 1992


Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR.

E-pub date: 31 Mar 1992


A combined n.m.r. and molecular biological approach to studying enzymes in vivo.

E-pub date: 01 Nov 1991


31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.

E-pub date: 31 Jan 1990


Phospholipid bilayer contribution to 31P NMR spectra in vivo.

E-pub date: 01 Nov 1989


31P NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo.

E-pub date: 30 Apr 1989


Determination of buffering capacity of rat myocardium during ischemia.

E-pub date: 31 Jul 1988


31P NMR magnetization-transfer measurements of flux between inorganic phosphate and adenosine 5′-triphosphate in yeast cells genetically modified to overproduce phosphoglycerate kinase.

E-pub date: 31 Jul 1988


31P-NMR saturation transfer studies of aerobic Escherichia coli cells.

E-pub date: 31 Mar 1988


31P NMR measurements of myocardial pH in vivo.

E-pub date: 31 Jan 1988


31P-NMR saturation transfer measurements of exchange between Pi and ATP in the reactions catalysed by glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in vitro.

E-pub date: 31 Mar 1987


A 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte.

E-pub date: 30 Jun 1986


Measurements of exchange in the reaction catalysed by creatine kinase using 14C and 15N isotope labels and the NMR technique of saturation transfer.

E-pub date: 31 May 1985


A multinuclear NMR study of 2,3-bisphosphoglycerate metabolism in the human erythrocyte.

E-pub date: 31 Aug 1984


The inhibition of erythrocyte glyceraldehyde-3-phosphate dehydrogenase. In situ PMR studies.

E-pub date: 31 May 1984


A comparison of 31P-NMR saturation transfer and isotope-exchange measurements of creatine kinase kinetics in vitro.

E-pub date: 31 Mar 1984


Proton NMR measurements of hydrogen exchange at the C-3 position of 3-hydroxybutyrate in suspensions of rat liver mitochondria.

E-pub date: 31 Oct 1983


Centrifugal analysis of undiluted packed human erythrocyte lysates. Studies of the association of glyceraldehyde-phosphate dehydrogenase with the membrane fraction.

E-pub date: 30 Jun 1983


A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte.

E-pub date: 30 Nov 1982


Observation of carbon labelling in cell metabolites using proton spin echo NMR.

E-pub date: 30 Nov 1982


Spin ECHO proton NMR studies of the metabolism of malate and fumarate in human erythrocytes. Dependence on free NAD levels.

E-pub date: 30 Sep 1982


A 1H n.m.r. study of isotope exchange catalysed by glycolytic enzymes in the human erythrocyte.

E-pub date: 28 Feb 1982


A p.m.r. isotope-exchange method for studying the kinetic properties of dehydrogenases in intact cells.

E-pub date: 28 Feb 1982


Studies of lactate dehydrogenase in the purified state and in intact erythrocytes.

E-pub date: 28 Feb 1982


Studies of pyruvate-water isotope exchange catalysed by erythrocytes and proteins.

E-pub date: 31 Jan 1981


1H/2H isotope exchange studies in intact erythrocytes.

E-pub date: 01 Oct 1980


Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport.

E-pub date: 31 Mar 1979


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
24/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
MedImmune No Yes No No No No No No
MedImmune Yes Yes No No No No No No
Astra Zeneca Yes Yes No No No No No No
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