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Cancer detection
Improving early cancer diagnoses and predicting treatment response.
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Tumour microenvironment
Unravelling tumour interactions to identify potential drug targets.
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Personalised medicine
Tailoring cancer treatment to individual needs.
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Artificial intelligence
Using artificial intelligence to enhance cancer research and treatments.
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Cell biology
Understanding every stage of a tumour through discovery science.
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Clinical integration
Maximising patient data for better cancer care.
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Personalising treatment for ovarian cancer patients: BriTROC-2
BriTROC-2 is a nationwide project developing personalised treatments for women diagnosed with High Grade Serous Ovarian Cancer.
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Artificial intelligence
Using artificial intelligence to enhance cancer research and treatments.
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Cancer detection
Improving early cancer diagnoses and predicting treatment response.
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Cell biology
Understanding every stage of a tumour through discovery science.
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Latest News
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Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
6th December 2024
An MRI-based imaging technique developed at the Institute predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
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Isabel Esain Garcia awarded PhD Thesis Prize
3rd December 2024
The Prize is awarded annually to a student who has undertaken an outstanding research project to the highest standards during the course of their PhD study at the Cancer Research UK Cambridge Institute.
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World first trial to revolutionise treatment of brain cancer
23rd October 2024
A pioneering research study will trial multiple new treatments for people in the UK living with glioblastoma, an aggressive form of brain cancer.
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Impact
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Personalising treatment for ovarian cancer patients: BriTROC-2
BriTROC-2 is a nationwide project developing personalised treatments for women diagnosed with High Grade Serous Ovarian Cancer.
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Non-invasive tests to improve cancer detection
Cambridge researchers have developed new methods for detecting and monitoring cancer through simple blood tests.
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Research Summary
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Prof Jason Carroll
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Deliver cancer research of the highest calibre
Our research will transform our understanding of every stage of a tumour lifecycle. We believe that only through understanding all aspects of the disease can we prevent, detect and treat cancer so that everybody can lead longer, better lives.
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We are attracting the brightest minds in research, both across the UK and globally, to create a dynamic and inclusive environment for all to accelerate scientific discovery. Our 20 research groups work collaboratively to bring about the most impactful discoveries and create an Institute-wide culture of tackling the most important questions in cancer research.
Core-funding from Cancer Research UK
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Deliver cancer research of the highest calibre
Our research will transform our understanding of every stage of a tumour lifecycle. We believe that only through understanding all aspects of the disease can we prevent, detect and treat cancer so that everybody can lead longer, better lives.
We are attracting the brightest minds in research, both across the UK and globally, to create a dynamic and inclusive environment for all to accelerate scientific discovery. Our 20 research groups work collaboratively to bring about the most impactful discoveries and create an Institute-wide culture of tackling the most important questions in cancer research.
Core-funding from Cancer Research UK
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Deliver cancer research of the highest calibre
Our research will transform our understanding of every stage of a tumour lifecycle. We believe that only through understanding all aspects of the disease can we prevent, detect and treat cancer so that everybody can lead longer, better lives.
Contact
We are attracting the brightest minds in research, both across the UK and globally, to create a dynamic and inclusive environment for all to accelerate scientific discovery. Our 20 research groups work collaboratively to bring about the most impactful discoveries and create an Institute-wide culture of tackling the most important questions in cancer research.
Core-funding from Cancer Research UK
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Deliver cancer research of the highest calibre
Our research will transform our understanding of every stage of a tumour lifecycle. We believe that only through understanding all aspects of the disease can we prevent, detect and treat cancer so that everybody can lead longer, better lives.
Chat with us
We are attracting the brightest minds in research, both across the UK and globally, to create a dynamic and inclusive environment for all to accelerate scientific discovery. Our 20 research groups work collaboratively to bring about the most impactful discoveries and create an Institute-wide culture of tackling the most important questions in cancer research.
Core-funding from Cancer Research UK
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Focus areas
Lineage tracing
To determine the fate of clones we need to be able to observe them. This can be done directly by visualizing them or indirectly using DNA sequencing to detect unique mutations. Visualisation can be done in a number of ways using genetically modified mice. It commonly involves inducing a low frequency of sporadic activation of reporter genes using tightly regulated site specific recombinases, e.g. Cre, Flp, Dre. The recombinases can be expressed from specific stem or progenitor populations, or throughout the tissue. Spontaneous somatic mutations can sometimes be visualized directly.
The composition, frequency and size of clones are determined and this quantitative assessment lends itself to mathematical interpretations to describe the processes by which grow and become fixed and infer the behaviours of the original individually marked cells, that are commonly stem cells.
Stem cell extinctions and expansions characterize the process by which surviving clones can eventually become fixed in the epithelium – by occupying the individual glands or crypts that characterise the epithelium.
Stem cell and clonality
Introduction
Cancers of the colon, like other cancers, arise from the abnormal growth of cells containing oncogenic mutations. This provides the motivation to understand in detail the molecular changes accompanying such mutations. In contrast the impact of mutations on cell fates within affected tissues receives relatively little attention. Yet cancers are comprised of expanded clones of cells. Every mutated clone has a natural history involving discrete steps that establishes the fate of the founding cell and of its clonal descendants to dictate their contribution to, and availability for, neoplastic transformation.
We investigate the origin of clones in the intestinal epithelium to understand the probability of their survival and expansion at each stage and how this varies with different mutations. By defining when during their natural history clones predisposed to cancer become permanently fixed and how much they subsequently grow we can tailor interventions appropriately: aiming either to promote their extinction or limit their growth.
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Introduction
Cancers of the colon, like other cancers, arise from the abnormal growth of cells containing oncogenic mutations. This provides the motivation to understand in detail the molecular changes accompanying such mutations. In contrast the impact of mutations on cell fates within affected tissues receives relatively little attention. Yet cancers are comprised of expanded clones of cells. Every mutated clone has a natural history involving discrete steps that establishes the fate of the founding cell and of its clonal descendants to dictate their contribution to, and availability for, neoplastic transformation.
We investigate the origin of clones in the intestinal epithelium to understand the probability of their survival and expansion at each stage and how this varies with different mutations. By defining when during their natural history clones predisposed to cancer become permanently fixed and how much they subsequently grow we can tailor interventions appropriately: aiming either to promote their extinction or limit their growth.
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“We are excited about studying the fundamental processes of this highly unusual but important protein. The insight will help us understand how specialised master regulators like FOXA1 can change the genomic landscape and ultimately the fate of a cell, which is important given that FOXA1 is a major driver in breast and prostate cancer. We thank the Wellcome Trust for the opportunity to conduct this work.”
Prof Jason Carrol
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ACED: International Alliance for Cancer Early Detection
ACED is a partnership between Cancer Research UK, Canary Center at Stanford University, the University of Cambridge, OHSU Knight Cancer Institute, UCL and The University of Manchester worth over £55 million.
The Cambridge ACED centre is co lead by Dr Sarah Bohndiek with Early Cancer Institute Director Professor Rebecca Fitzgerald. It is made up of 355 members from organisations that include The University of Cambridge, the Gurdon and Wellcome Sanger Institutes, and NHS Departments.
The Centre designs, develops and delivers Clinical Infrastructure for Research in Early Detection, a clinical facility that will enable early phase clinical trials of novel diagnostics. This will be key to test and validate early diagnostics and accelerate adoption of the most promising early detection approaches by doctors.
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Black in Cancer
We are proud to house the UK Headquarters of Black in Cancer, an organisation dedicated to strengthen the network between Black people in the cancer space whilst highlighting Black excellence in cancer research and medicine.
We have partnered with Black in Cancer to offer two summer research places to UK undergraduate students on the Black and Cancer mentorship scheme. Mentees are matched with a mentor from academia or industry currently contributing to the fight against cancer, for career mentoring.
Mentees in the scheme will receive training outside of the mentorship including coaching events and presentation training.
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Group Members
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Clive D'Santos
Core Facility Manager
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Valar Franklin
Senior Scientific Associate
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Eva Papachristou
Principle Scientific Associate
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My Group Members
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Raza Ali
Group Leader
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Neus Masque Soler
Principal Scientific Associate
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Shimrit Mayer
Research Associate
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Atif Khan
Research Associate
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Ciccy Wang
Postgraduate Student
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Ellen Schrader
Postgraduate Student
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Lubna Ahmad
Postgraduate Student
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Caroline Caruso Carter
Postgraduate Student
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Ioanna Karouzou
Research Administrator
Latest News
See all news-
Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
6th December 2024
An MRI-based imaging technique developed at the Institute predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
Find out more -
World renowned Cambridge scientists back call for urgent investment
22nd February 2024
A coalition of the world’s most renowned cancer researchers, have joined forces with Cancer Research UK to call on philanthropists.
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Knighthood for Professor Stephen Jackson
16th June 2023
Prof Stephen Philip Jackson has been awarded a knighthood in the King’s first Birthday Honours List for his services to innovation and research.
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Seminar Feed
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How to Fold Every Protein: (Mission Accomplished?)
- 10 Dec 2024 05:13 pm – 05:13 pm
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Understanding the cancer genome base-by-base
- 10 Dec 2024 05:13 pm – 05:13 pm
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Understanding Mechanisms of Microenvironment-Mediated Therapy Resistance
- 10 Dec 2024 05:13 pm – 05:13 pm
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Cancer metabolism, a hallmark of cancer
- 10 Dec 2024 05:13 pm – 05:13 pm