Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates.
- Abstract:
- Herein we describe the development of a novel azobenzene-containing glutathione-cleavable linker for use in antibody-drug conjugates (ADCs). This linker demonstrated efficient payload release under elevated glutathione levels while maintaining stability in human plasma. An anti-HER2 ADC incorporating this linker exhibited potent in vitro cytotoxicity and selective activity towards HER2-positive cell lines.
- Authors:
- M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
- Journal:
- Chem Commun (Camb)
- Citation info:
- 61(95):18902-18905
- Publication date:
- 25th Nov 2025
- Full text
- DOI