Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas
- Abstract:
- Regulatory T cells are fundamentally important for maintaining immune homeostasis, and their potent immune-suppressive roles make them attractive immunotherapeutic targets in cancer. Recent work suggests potential functions of tissue-resident Tregs (trTregs) in tissue-repair and epithelial cell homeostasis. Here, we describe a rare population of trTreg in the exocrine pancreas. We show that these cells share common features of trTregs, including expression of the IL-33 receptor ST2 and production of the epithelial growth factor Amphiregulin, and display an oligoclonal T cell receptor repertoire. Using a mouse model of acute pancreatitis, we show that pancreatic Tregs rapidly expand upon release of IL-33 by fibroblasts. Moreover, depletion of Tregs after initiation of pancreatic injury impairs the regeneration of the exocrine parenchyma. This effect is due, in part, through a direct effect of Tregs on acinar cell proliferation. Finally, we show that transient Treg depletion in established orthotopic pancreatic tumours leads to tumour rejection yet provokes long-lasting damages to surrounding exocrine parenchyma. In all, our results demonstrate the tissue-repair capacity of pancreatic Tregs, and highlight a dualistic role of these cells in the pancreatic tumour ecosystem, with their harmful immune-suppressive function in the tumour coupled to a beneficial tissue-repair function in the surrounding tissue.
- Authors:
- J Stockis, T Yip, S Raghunathan, C Garcia, S Lee, C Simpson, S Pinaud, MJ Schuijs, JA HenrĂquez, S Png, G Raddi, O Bricard, TY So, S Mack, P Papadopoulos, A Sawle, DI Jodrell, ANJ McKenzie, JED Thaventhiran, MR Clatworthy, G Biffi, K Saeb-Parsy, A Liston, TYF Halim
- Publication date:
- 21st Feb 2024
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- DOI