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Figure 1 from Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models

Abstract:
<p>Bevacizumab provides a survival benefit in a subset of MDA-MB-231 tumors but not MCF7 tumors. <b>A,</b> Illustrative overview of study design (created with BioRender.com). Mouse viewpoint from left side shows only the left flank tumor; right flank tumor not shown. <b>B,</b> Survival curves for control (Ctrl) and bevacizumab (Bev)-treated groups in MCF7 tumor-bearing mice (top, <i>n</i><sub>mice</sub> = 4 Ctrl; <i>n</i><sub>mice</sub> = 4 Bev) and MDA-MB-231 tumor-bearing mice (bottom, <i>n</i><sub>mice</sub> = 8 Ctrl; <i>n</i><sub>mice</sub> = 11 Bev). <b>C,</b> Estimated average tumor growth per group for the control group and the bevacizumab-treated group of MDA-MB-231 mice (<i>n</i><sub>tumors</sub> = 14 Ctrl; <i>n</i><sub>tumors</sub> = 20 Bev), illustrating the durable response obtained in the subset of the treated group denoted as responders (Bev-R) compared with nonresponders (Bev-NR) based on their tumor growth rates (see Supplementary Data). Shaded areas show 95% pointwise confidence bounds for the average. The largest tumor volume recorded in the study was less than 3,200 mm<sup>3</sup> in accordance with our ethical limits; data beyond this volume is an extrapolation of our linear model to illustrate the trajectory of growth in Ctrl and Bev-NR tumors. Weeks denoted in <b>B</b> and <b>C</b> are from the time of enrollment.</p>
Article has an altmetric score of 89
Authors:
I Quiros-Gonzalez, MR Tomaszewski, MA Golinska, E Brown, L Ansel-Bollepalli, L Hacker, D-L Couturier, RM Sainz, SE Bohndiek
Publication date:
24th Nov 2025
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