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Figure 6 from Imaging Glioblastoma Response to Radiotherapy Using 2H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism

Abstract:
<p>DCE MRI measurements of perfusion in A11 (<i>n</i> = 3; <b>A–C</b>), S2 (<i>n</i> = 3; <b>D–F</b>), and U87 (<i>n</i> = 3; <b>G–I</b>) tumors before and after treatment. Representative color intensity maps of mean contrast agent concentration over the first three minutes following injection in A11 (<b>A</b>), S2 (<b>D</b>), and U87 (<b>G</b>) tumors. The locations of the tumors are outlined by dotted white lines. Estimated contrast agent concentration in tumor tissue at the indicated times after intravenous injection before and 48 hours following the last chemoradiotherapy treatment of A11 (<b>B</b>), S2 (<b>E</b>), and U87 (<b>H</b>) tumors. Data are shown as mean ± SD; *, <i>P</i> < 0.05; ***, <i>P</i> < 0.001. The area under the uptake curve (AUC) showed an increase in contrast agent uptake in S2 tumors (**, <i>P</i> = 0.0024, paired two-tailed <i>t</i> test) following treatment (<b>F</b>), while there were no significant differences in A11 (<b>C</b>) and U87 (<b>I</b>) tumor-bearing animals. Data are presented as mean ± SD. ns, nonsignificant.</p>
Article has an altmetric score of 89
Authors:
F Hesse, AJ Wright, V Somai, F Bulat, F Kreis, KM Brindle
Publication date:
24th Nov 2025
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