Regulatory systems biology
We are interested in understanding the molecular basis behind the regulatory evolution of tissues, species and cancer. We typically begin our studies using liver and liver cancer as model systems. Our interest in transcriptional regulation encompasses the roles of transcription factors, insulator elements such as CTCF, non-coding RNAs and repetitive elements. We have used Next Generation Sequencing (NGS) extensively and are now incorporating CRISPR/Cas9 and single cell sequencing technologies into our ongoing projects.