Cellular and molecular origins of cancer
The principal aim of my research is to improve the accuracy of brain tumour classification and treatment, avoiding long-term side effects for those who can be cured, whilst providing new therapeutic targets to guide future treatment. With a particular focus on children’s brain tumours. We are working to understand the cellular and molecular origins of cancers and the pathways that drive them. We hope to achieve this goal by:
- Conducting extensive genomic analyses of brain tumours to identify cancer-causing genetic abnormalities.
- Understanding the impact of signalling pathways on normal stem cell biology and tissue development
- Integrating studies of genetic and cell signal alterations in cancers with studies of normal progenitor cells to determine the cellular and molecular origins of tumours
- Translating knowledge of tumour biology into effective new cancer cures through pre-clinical and early clinical trials of molecular targeted therapies.
These findings are among the most important to have come out of my lab for three decades. Not only have we identified one of the elusive drivers of metastasis, but we have also turned a commonly held understanding of this on its head showing how cancer hijacks processes in healthy cells for its own gains.Prof Richard Gilbertson, on Rahrmann et al, Nature Genetics 2022
The NALCN channel regulates metastasis and nonmalignant cell dissemination.E-pub date: 1 Dec 2022Journal name: Nat Genet
ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors.E-pub date: 1 Sep 2021Journal name: Cancer Discov
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.E-pub date: 24 Aug 2020Journal name: Dev Cell
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.E-pub date: 1 Sep 2019Journal name: Nature
Establishing a Preclinical Multidisciplinary Board for Brain Tumors.E-pub date: 1 Apr 2018Journal name: Clin Cancer Res