Visiting Scientist

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo.

E-pub date: 30 Nov 2019


The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.

E-pub date: 30 Sep 2019


Correction to: Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

E-pub date: 31 Mar 2019


Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

E-pub date: 28 Feb 2019


Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.

E-pub date: 31 Jan 2019


Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

E-pub date: 30 Nov 2018


Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.

E-pub date: 01 Oct 2018


Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

E-pub date: 31 Aug 2018


cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway.

E-pub date: 15 May 2018


Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase.

E-pub date: 01 May 2018


Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.

E-pub date: 06 Apr 2018


Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94-162].

E-pub date: 01 Apr 2018


Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.

E-pub date: 19 Feb 2018


cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.

E-pub date: 12 Dec 2017


European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

E-pub date: 31 Oct 2017


MitoNeoD: A Mitochondria-Targeted Superoxide Probe.

E-pub date: 19 Oct 2017


Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.

E-pub date: 01 Sep 2017


Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA.

E-pub date: 12 May 2017


Functional assessment and transplantation of the donor heart after circulatory death.

E-pub date: 31 Dec 2016


Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.

E-pub date: 15 Jul 2016


Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.

E-pub date: 04 Mar 2016


Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.

E-pub date: 09 Feb 2016


A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.

E-pub date: 09 Feb 2016


Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions.

E-pub date: 31 Jan 2016


Adenosine receptor activation improves microcirculation in experimental intestinal ischemia/reperfusion.

E-pub date: 31 Aug 2015


Combining MRI with PET for partial volume correction improves image-derived input functions in mice.

E-pub date: 01 Jun 2015


Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

E-pub date: 20 Nov 2014


Trajectory correction for free-breathing radial cine MRI.

E-pub date: 01 Sep 2014


Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.

E-pub date: 31 Aug 2014


Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.

E-pub date: 31 Aug 2014


Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.

E-pub date: 31 Jul 2014


P439Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury.

E-pub date: 15 Jul 2014


P516Diastolic dysfunction in diabetic mice revealed by MRI.

E-pub date: 30 Jun 2014


Functional assessment of the mouse heart by MRI with a 1-min acquisition.

E-pub date: 01 Jun 2014


A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.

E-pub date: 01 Feb 2014


Using exomarkers to assess mitochondrial reactive species in vivo.

E-pub date: 01 Feb 2014


6 s-nitrosation of a cysteine switch on mitochondrial complex I protects from acute ischaemia-reperfusion damage and post myocardial infarction heart failure.

E-pub date: 31 Jan 2014


PET/MRI assessment of the infarcted mouse heart.

E-pub date: 31 Dec 2013


MRI and PET in mouse models of myocardial infarction.

E-pub date: 19 Dec 2013


A fast protocol for infarct quantification in mice.

E-pub date: 31 Aug 2013


Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.

E-pub date: 31 Aug 2013


Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

E-pub date: 01 Jun 2013


Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G.

E-pub date: 31 Mar 2013


PET/MRI in the infarcted mouse heart with the Cambridge split magnet.

E-pub date: 31 Jan 2013


Oxidative and nitrosative stress in the maintenance of myocardial function.

E-pub date: 15 Oct 2012


All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.

E-pub date: 01 Jun 2012


Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.

E-pub date: 31 May 2011


A2b adenosine receptors in cardioprotection: timing is everything.

E-pub date: 31 Mar 2011


Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.

E-pub date: 31 Oct 2010


Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels.

E-pub date: 01 Oct 2010


Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.

E-pub date: 31 Jul 2010


Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion.

E-pub date: 31 Jul 2010


AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.

E-pub date: 31 Jan 2010


Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8.

E-pub date: 31 Dec 2009


BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.

E-pub date: 31 Jul 2009


Prostaglandin receptors mediate effects of substances released from ischaemic rat hearts on non-ischaemic cardiomyocytes.

E-pub date: 31 Dec 2008


Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.

E-pub date: 31 May 2008


Mapping preconditioning’s signaling pathways: an engineering approach.

E-pub date: 31 Mar 2008


Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice.

E-pub date: 31 Mar 2008


Making the heart resistant to infarction: how can we further decrease infarct size?

E-pub date: 31 Dec 2007


The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

E-pub date: 01 Nov 2007


COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.

E-pub date: 31 Oct 2007


The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation.

E-pub date: 01 Sep 2007


Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.

E-pub date: 01 Apr 2007


P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

E-pub date: 01 Sep 2003


Mitochondria and their role in preconditioning’s trigger phase.

E-pub date: 01 Jul 2003


Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.

E-pub date: 31 Mar 2003


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