Group Leader

Research Group Home Page: 
Gilbertson Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Multiomic Medulloblastomas.

E-pub date: 31 Aug 2018


A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.

E-pub date: 26 Jun 2018


Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

E-pub date: 01 Jun 2018


Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

E-pub date: 01 Jun 2018


Establishing a Preclinical Multidisciplinary Board for Brain Tumors.

E-pub date: 01 Apr 2018


A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

E-pub date: 01 Jan 2018


mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

E-pub date: 18 Dec 2017


Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.

E-pub date: 14 Sep 2017


Brain Tumors: Challenges and Opportunities to Cure.

E-pub date: 20 Jul 2017


The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.

E-pub date: 31 Jan 2017


Highlights of Children with Cancer UK’s Workshop on Drug Delivery in Paediatric Brain Tumours.

E-pub date: 31 Aug 2016


Multi-organ Mapping of Cancer Risk.

E-pub date: 25 Aug 2016


Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.

E-pub date: 16 May 2016


Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

E-pub date: 11 Apr 2016


Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study.

E-pub date: 01 Apr 2016


Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma.

E-pub date: 01 Apr 2016


Preclinical studies of 5-fluoro-2′-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

E-pub date: 31 Jan 2016


Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.

E-pub date: 31 Dec 2015


Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.

E-pub date: 31 Aug 2015


An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.

E-pub date: 31 Aug 2015


Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

E-pub date: 20 Aug 2015


Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

E-pub date: 02 Jul 2015


Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study.

E-pub date: 31 May 2015


An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).

E-pub date: 31 May 2015


Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.

E-pub date: 11 May 2015


Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

E-pub date: 11 May 2015


Orthotopic models of pediatric brain tumors in zebrafish.

E-pub date: 26 Mar 2015


A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors: a pediatric brain tumor consortium study.

E-pub date: 01 Feb 2015


Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups.

E-pub date: 01 Jan 2015


Molecular insights into pediatric brain tumors have the potential to transform therapy.

E-pub date: 15 Nov 2014


The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.

E-pub date: 01 Sep 2014


Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

E-pub date: 24 Jul 2014


UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.

E-pub date: 25 Apr 2014


Driving glioblastoma to drink.

E-pub date: 10 Apr 2014


The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.

E-pub date: 08 Apr 2014


C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

E-pub date: 27 Feb 2014


Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas–a Pediatric Brain Tumor Consortium study.

E-pub date: 31 Jan 2014


Bevacizumab (BVZ)-associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT-11): a Pediatric Brain Tumor Consortium Study (PBTC-022).

E-pub date: 01 Dec 2013


Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.

E-pub date: 15 Nov 2013


The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy.

E-pub date: 06 Nov 2013


A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children’s Oncology Group phase 1 consortium study.

E-pub date: 01 Sep 2013


A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

E-pub date: 01 Sep 2013


Histological predictors of outcome in ependymoma are dependent on anatomic site within the central nervous system.

E-pub date: 01 Sep 2013


Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.

E-pub date: 01 Jun 2013


Medulloblastomics: the end of the beginning.

E-pub date: 31 Dec 2012


Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.

E-pub date: 11 Dec 2012


Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma–a Pediatric Brain Tumor Consortium study.

E-pub date: 01 Nov 2012


Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.

E-pub date: 01 Sep 2012


Novel mutations target distinct subgroups of medulloblastoma.

E-pub date: 02 Aug 2012


Review: developmental origins of neural tumours: old idea, new approaches.

E-pub date: 01 Jun 2012


WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.

E-pub date: 31 May 2012


A prognostic gene expression signature in infratentorial ependymoma.

E-pub date: 31 May 2012


There’s a time and a place for MYCN.

E-pub date: 15 May 2012


Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.

E-pub date: 01 Apr 2012


Molecular subgroups of medulloblastoma: the current consensus.

E-pub date: 01 Apr 2012


Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children’s Cancer Leukaemia Group (CCLG), Societe Francaise d’Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP).

E-pub date: 01 Apr 2012


A mouse model of the most aggressive subgroup of human medulloblastoma.

E-pub date: 14 Feb 2012


Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

E-pub date: 29 Jan 2012


A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.

E-pub date: 01 Nov 2011


Finding the perfect partner for medulloblastoma prognostication.

E-pub date: 10 Oct 2011


An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.

E-pub date: 13 Sep 2011


Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

E-pub date: 10 Sep 2011


Developing treatment strategies for rare cancers.

E-pub date: 01 Sep 2011


The brain tumor microenvironment.

E-pub date: 31 Aug 2011


A procedure to statistically evaluate agreement of differential expression for cross-species genomics.

E-pub date: 01 Aug 2011


Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors.

E-pub date: 20 Jul 2011


TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas.

E-pub date: 20 Apr 2011


Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.

E-pub date: 10 Apr 2011


Rapid diagnosis of medulloblastoma molecular subgroups.

E-pub date: 01 Apr 2011


Mapping cancer origins.

E-pub date: 01 Apr 2011


Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.

E-pub date: 31 Mar 2011


A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas.

E-pub date: 31 Dec 2010


Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.

E-pub date: 24 Dec 2010


Subtypes of medulloblastoma have distinct developmental origins.

E-pub date: 30 Nov 2010


Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma.

E-pub date: 01 Nov 2010


Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study.

E-pub date: 20 Sep 2010


Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children’s Oncology Group phase I consortium report.

E-pub date: 01 Aug 2010


Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

E-pub date: 29 Jul 2010


Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study.

E-pub date: 20 Jun 2010


To infinium, and beyond!

E-pub date: 18 May 2010


Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop.

E-pub date: 01 Feb 2010


Dual and opposing roles of primary cilia in medulloblastoma development.

E-pub date: 01 Sep 2009


Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.

E-pub date: 01 Apr 2009


The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

E-pub date: 24 Feb 2009


A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET.

E-pub date: 01 Feb 2009


Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.

E-pub date: 29 Jan 2009


Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.

E-pub date: 01 Jan 2009


Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.

E-pub date: 31 Dec 2008


Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma.

E-pub date: 31 Oct 2008


Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children’s Oncology Group Phase I Consortium Study.

E-pub date: 20 Oct 2008


The niche revealed.

E-pub date: 11 Sep 2008


The origins of medulloblastoma subtypes.

E-pub date: 31 Aug 2008


Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop.

E-pub date: 15 Jul 2008


Molecular characterization of the pediatric preclinical testing panel.

E-pub date: 15 Jul 2008


Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma.

E-pub date: 01 Jun 2008


Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.

E-pub date: 31 Jan 2008


Making a tumour’s bed: glioblastoma stem cells and the vascular niche.

E-pub date: 31 Oct 2007


Phase I study of everolimus in pediatric patients with refractory solid tumors.

E-pub date: 20 Oct 2007


Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma.

E-pub date: 16 Jul 2007


Tumorigenesis in the brain: location, location, location.

E-pub date: 15 Jun 2007


Regression of experimental medulloblastoma following transfer of HER2-specific T cells.

E-pub date: 15 Jun 2007


Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature.

E-pub date: 01 Jun 2007


A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children’s Oncology Group study.

E-pub date: 15 Mar 2007


Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.

E-pub date: 15 Mar 2007


Clinical and molecular characteristics of malignant transformation of low-grade glioma in children.

E-pub date: 20 Feb 2007


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