Senior Group Leader

Research Group Home Page: 
Narita Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Short-term gain, long-term pain: the senescence life cycle and cancer.

E-pub date: 31 Jan 2019


Crisis management by autophagy.

E-pub date: 31 Dec 2018


Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.

E-pub date: 31 Oct 2018


AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice.

E-pub date: 31 Aug 2018


Mouse Models of COPD.

E-pub date: 01 Aug 2018


NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.

E-pub date: 09 May 2018


Effects of Household Air Pollution in Malawi and Human Immunodeficiency Virus Status on Respiratory Symptoms and Inflammation, Injury, and Repair Markers.

E-pub date: 01 Apr 2018


A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

E-pub date: 01 Jan 2018


Notch and Senescence.

E-pub date: 01 Jan 2018


Spatial and Temporal Control of Senescence.

E-pub date: 01 Nov 2017


Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells.

E-pub date: 30 Sep 2017


Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy.

E-pub date: 31 Aug 2017


A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds.

E-pub date: 31 Aug 2017


Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma.

E-pub date: 01 Aug 2017


Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure.

E-pub date: 01 Aug 2017


Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice.

E-pub date: 30 Jun 2017


Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome.

E-pub date: 31 Mar 2017


NOTCH and the 2 SASPs of senescence.

E-pub date: 01 Feb 2017


G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016


NOTCH1 mediates a switch between two distinct secretomes during senescence.

E-pub date: 01 Sep 2016


Old cells, new tricks: chromatin structure in senescence.

E-pub date: 31 Aug 2016


Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

E-pub date: 31 Aug 2016


Erratum.

E-pub date: 31 Aug 2016


Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS.

E-pub date: 01 Aug 2016


Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia.

E-pub date: 01 Apr 2016


Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.

E-pub date: 04 Mar 2016


Translating the effects of mTOR on secretory senescence.

E-pub date: 31 Oct 2015


CELL BIOLOGY. GATA get a hold on senescence.

E-pub date: 25 Sep 2015


Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

E-pub date: 01 Sep 2015


Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

E-pub date: 01 Sep 2015


Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

E-pub date: 31 Aug 2015


Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.

E-pub date: 31 Aug 2015


The expanding territories of condensin II.

E-pub date: 31 Aug 2015


Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

E-pub date: 31 Mar 2015


14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax.

E-pub date: 13 Mar 2015


Space radiation-associated lung injury in a murine model.

E-pub date: 28 Feb 2015


Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.

E-pub date: 14 Nov 2014


Inside and out: the activities of senescence in cancer.

E-pub date: 31 Aug 2014


Normalization of metabolomics data with applications to correlation maps.

E-pub date: 01 Aug 2014


Active trafficking of alpha 1 antitrypsin across the lung endothelium.

E-pub date: 01 Aug 2014


Vertebral erosion: an uncommon complication of tracheal tubes.

E-pub date: 15 Jul 2014


Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress.

E-pub date: 31 Mar 2014


HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.

E-pub date: 15 Feb 2014


Effects of lipid interactions on model vesicle engulfment by alveolar macrophages.

E-pub date: 04 Feb 2014


Cellular senescence and its effector programs.

E-pub date: 15 Jan 2014


Cell senescence as both a dynamic and a static phenotype.

E-pub date: 31 Aug 2013


Transmitting senescence to the cell neighbourhood.

E-pub date: 31 Aug 2013


Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.

E-pub date: 15 Aug 2013


High-order chromatin structure and the epigenome in SAHFs.

E-pub date: 31 Jan 2013


In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs.

E-pub date: 31 Jan 2013


RTP801 is required for ceramide-induced cell-specific death in the murine lung.

E-pub date: 31 Jan 2013


Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis.

E-pub date: 31 Dec 2012


Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.

E-pub date: 27 Jul 2012


Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.

E-pub date: 01 Jun 2012


Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases.

E-pub date: 09 May 2012


Rags connect mTOR and autophagy.

E-pub date: 01 Apr 2012


Cancer cell senescence: a new frontier in drug development.

E-pub date: 31 Mar 2012


Autophagy in cancer: having your cake and eating it.

E-pub date: 31 Dec 2011


Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides.

E-pub date: 31 Dec 2011


Dihydroceramide-based response to hypoxia.

E-pub date: 04 Nov 2011


Spatio-temporal association between mTOR and autophagy during cellular senescence.

E-pub date: 01 Nov 2011


NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.

E-pub date: 31 Aug 2011


Spatial coupling of mTOR and autophagy augments secretory phenotypes.

E-pub date: 20 May 2011


Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.

E-pub date: 01 Apr 2011


The tumor suppressor ING1 contributes to epigenetic control of cellular senescence.

E-pub date: 01 Feb 2011


Impact of cellular senescence signature on ageing research.

E-pub date: 31 Jan 2011


HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes.

E-pub date: 15 Jan 2011


Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.

E-pub date: 31 Jul 2010


Quality and quantity control of proteins in senescence.

E-pub date: 31 May 2010


Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

E-pub date: 13 Apr 2010


Connecting autophagy to senescence in pathophysiology.

E-pub date: 01 Apr 2010


Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.

E-pub date: 15 Feb 2010


Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma.

E-pub date: 01 Sep 2009


Autophagy mediates the mitotic senescence transition.

E-pub date: 01 Apr 2009


SASP reflects senescence.

E-pub date: 31 Mar 2009


Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.

E-pub date: 31 Oct 2008


Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

E-pub date: 24 Oct 2008


Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.

E-pub date: 31 Jul 2008


Oncogenic HMGA2: short or small?

E-pub date: 01 May 2007


Cellular senescence and chromatin organisation.

E-pub date: 12 Mar 2007


Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells.

E-pub date: 01 Sep 1999


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
24/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
Menicon Yes No No No No No No Yes
Yodosha No No No No No Yes No No
Pfizer No No No No No Yes No No
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