Senior Group Leader

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Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.

E-pub date: 28 Feb 2019

Short-term gain, long-term pain: the senescence life cycle and cancer.

E-pub date: 31 Jan 2019

Crisis management by autophagy.

E-pub date: 31 Dec 2018

Bioactive Sphingolipids in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

E-pub date: 01 Dec 2018

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.

E-pub date: 31 Oct 2018

LION LBD: a Literature-Based Discovery System for Cancer Biology.

E-pub date: 30 Sep 2018

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice.

E-pub date: 31 Aug 2018

Mouse Models of COPD.

E-pub date: 01 Aug 2018

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.

E-pub date: 09 May 2018

Effects of Household Air Pollution in Malawi and Human Immunodeficiency Virus Status on Respiratory Symptoms and Inflammation, Injury, and Repair Markers.

E-pub date: 01 Apr 2018

A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

E-pub date: 01 Jan 2018

Notch and Senescence.

E-pub date: 01 Jan 2018

Spatial and Temporal Control of Senescence.

E-pub date: 01 Nov 2017

Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells.

E-pub date: 30 Sep 2017

Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy.

E-pub date: 31 Aug 2017

A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds.

E-pub date: 31 Aug 2017

Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma.

E-pub date: 01 Aug 2017

Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure.

E-pub date: 01 Aug 2017

Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice.

E-pub date: 30 Jun 2017

Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome.

E-pub date: 31 Mar 2017

NOTCH and the 2 SASPs of senescence.

E-pub date: 01 Feb 2017

G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016

NOTCH1 mediates a switch between two distinct secretomes during senescence.

E-pub date: 01 Sep 2016

Old cells, new tricks: chromatin structure in senescence.

E-pub date: 31 Aug 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

E-pub date: 31 Aug 2016


E-pub date: 31 Aug 2016

Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS.

E-pub date: 01 Aug 2016

Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia.

E-pub date: 01 Apr 2016

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa.

E-pub date: 04 Mar 2016

Translating the effects of mTOR on secretory senescence.

E-pub date: 31 Oct 2015

CELL BIOLOGY. GATA get a hold on senescence.

E-pub date: 25 Sep 2015

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

E-pub date: 01 Sep 2015

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

E-pub date: 01 Sep 2015

Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

E-pub date: 31 Aug 2015

Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.

E-pub date: 31 Aug 2015

The expanding territories of condensin II.

E-pub date: 31 Aug 2015

Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

E-pub date: 31 Mar 2015

14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax.

E-pub date: 13 Mar 2015

Space radiation-associated lung injury in a murine model.

E-pub date: 28 Feb 2015

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.

E-pub date: 14 Nov 2014

Inside and out: the activities of senescence in cancer.

E-pub date: 31 Aug 2014

Normalization of metabolomics data with applications to correlation maps.

E-pub date: 01 Aug 2014

Active trafficking of alpha 1 antitrypsin across the lung endothelium.

E-pub date: 01 Aug 2014

Vertebral erosion: an uncommon complication of tracheal tubes.

E-pub date: 15 Jul 2014

Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress.

E-pub date: 31 Mar 2014

HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.

E-pub date: 15 Feb 2014

Effects of lipid interactions on model vesicle engulfment by alveolar macrophages.

E-pub date: 04 Feb 2014

Cellular senescence and its effector programs.

E-pub date: 15 Jan 2014

Cell senescence as both a dynamic and a static phenotype.

E-pub date: 31 Aug 2013

Transmitting senescence to the cell neighbourhood.

E-pub date: 31 Aug 2013

Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.

E-pub date: 15 Aug 2013

High-order chromatin structure and the epigenome in SAHFs.

E-pub date: 31 Jan 2013

In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs.

E-pub date: 31 Jan 2013

RTP801 is required for ceramide-induced cell-specific death in the murine lung.

E-pub date: 31 Jan 2013

Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis.

E-pub date: 31 Dec 2012

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.

E-pub date: 27 Jul 2012

Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.

E-pub date: 01 Jun 2012

Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases.

E-pub date: 09 May 2012

Rags connect mTOR and autophagy.

E-pub date: 01 Apr 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

E-pub date: 01 Apr 2012

Cancer cell senescence: a new frontier in drug development.

E-pub date: 31 Mar 2012

Autophagy in cancer: having your cake and eating it.

E-pub date: 31 Dec 2011

Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides.

E-pub date: 31 Dec 2011

Dihydroceramide-based response to hypoxia.

E-pub date: 04 Nov 2011

Spatio-temporal association between mTOR and autophagy during cellular senescence.

E-pub date: 01 Nov 2011

NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.

E-pub date: 31 Aug 2011

Spatial coupling of mTOR and autophagy augments secretory phenotypes.

E-pub date: 20 May 2011

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.

E-pub date: 01 Apr 2011

The tumor suppressor ING1 contributes to epigenetic control of cellular senescence.

E-pub date: 01 Feb 2011

Impact of cellular senescence signature on ageing research.

E-pub date: 31 Jan 2011

HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes.

E-pub date: 15 Jan 2011

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.

E-pub date: 31 Jul 2010

Quality and quantity control of proteins in senescence.

E-pub date: 31 May 2010

Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

E-pub date: 13 Apr 2010

Connecting autophagy to senescence in pathophysiology.

E-pub date: 01 Apr 2010

Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.

E-pub date: 15 Feb 2010

Autophagy facilitates oncogene-induced senescence.

E-pub date: 01 Oct 2009

Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma.

E-pub date: 01 Sep 2009

Autophagy mediates the mitotic senescence transition.

E-pub date: 01 Apr 2009

SASP reflects senescence.

E-pub date: 31 Mar 2009

Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.

E-pub date: 31 Oct 2008

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

E-pub date: 24 Oct 2008

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.

E-pub date: 31 Jul 2008

Oncogenic HMGA2: short or small?

E-pub date: 01 May 2007

Cellular senescence and chromatin organisation.

E-pub date: 12 Mar 2007

alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

E-pub date: 01 Oct 2006

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

E-pub date: 31 May 2003

Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells.

E-pub date: 01 Sep 1999

Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages.

E-pub date: 31 Mar 1999

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.

E-pub date: 30 Nov 1998

Independent prognostic factors in breast cancer patients.

E-pub date: 01 Jan 1998

A Case of Microangiopathic Hemolytic Anemia Associated with Breast Cancer: Improvement with Chemoendocrine Therapy.

E-pub date: 28 Feb 1997

Three nonsense mutations responsible for group A xeroderma pigmentosum.

E-pub date: 01 Mar 1992

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