Visiting Scientist

Research Group Home Page: 
VISION Lab

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019


DNA G-quadruplex structures mold the DNA methylome.

E-pub date: 30 Sep 2018


Unraveling Mechanisms of Chiral Induction in Double-Helical Metallopolymers.

E-pub date: 31 Jul 2018


Machine learning model for sequence-driven DNA G-quadruplex formation.

E-pub date: 06 Nov 2017


DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

E-pub date: 31 May 2017


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

E-pub date: 17 Feb 2017


Proximity-Induced H-Aggregation of Cyanine Dyes on DNA-Duplexes.

E-pub date: 22 Dec 2016


G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016


High-throughput sequencing of DNA G-quadruplex structures in the human genome.

E-pub date: 31 Aug 2015


G-quadruplex ligands exhibit differential G-tetrad selectivity.

E-pub date: 11 May 2015


Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

E-pub date: 12 Jan 2015


Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

E-pub date: 12 Jan 2015


Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand.

E-pub date: 23 Apr 2014


Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

E-pub date: 31 Jan 2014


Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

E-pub date: 04 Oct 2013


G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

E-pub date: 03 Jul 2013


Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

E-pub date: 26 Feb 2013


An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes.

E-pub date: 28 Jan 2013


Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

E-pub date: 29 Oct 2012


Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

E-pub date: 28 Aug 2012


Experimental approaches to identify cellular G-quadruplex structures and functions.

E-pub date: 31 May 2012


Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.

E-pub date: 14 Apr 2012


Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

E-pub date: 31 Aug 2011


Quinone methide generation via photoinduced electron transfer.

E-pub date: 06 May 2011


Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.

E-pub date: 20 Oct 2010


Substituted heterocyclic naphthalene diimides with unexpected acidity. Synthesis, properties, and reactivity.

E-pub date: 20 Nov 2009


Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.

E-pub date: 16 Sep 2009


Novel naphthalene diimides as activatable precursors of bisalkylating agents, by reduction and base catalysis.

E-pub date: 26 Oct 2007


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