For about 15 years I was involved in the statistical design and analysis of clinical studies at the Mario Negri Institute of Milan, Italy. My great mentors have been Professor Silvio Garattini and Dr Valter Torri. Then I discovered the complexity of biology by chance. I became a member of the institutional Animal Welfare and Ethics Review Body as methodologist. I completed my PhD at the Open University with a thesis on the methodological pitfalls of Preclinical In Vivo Antitumor Activity Experiments. A new framework for their design and analysis was also proposed. I joined the CRUK CI in April 2023.