Greg Hannon

Director of the CRI

Research Group Home Page:: Hannon Group

Work address:: Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Publications:: Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

E-pub date: 31 Jul 2019; Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019; piRNA-guided co-transcriptional silencing coopts nuclear export factors.

E-pub date: 31 May 2019; Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.

E-pub date: 30 Apr 2019; lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.

E-pub date: 31 Mar 2019; piRNA-Guided Genome Defense: From Biogenesis to Silencing.

E-pub date: 31 Oct 2018; Corrigendum to “GoldCLIP: Gel-omitted Ligation-dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

E-pub date: 01 Jun 2018; Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

E-pub date: 01 Jun 2018; COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

E-pub date: 02 Apr 2018; GoldCLIP: Gel-omitted Ligation-dependent CLIP.

E-pub date: 01 Apr 2018; Asparagine bioavailability governs metastasis in a model of breast cancer.

E-pub date: 15 Feb 2018; Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

E-pub date: 01 Feb 2018; lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

E-pub date: 06 Sep 2017; A Model for Epigenetic Inhibition via Transvection in the Mouse.

E-pub date: 01 Sep 2017; A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 31 Aug 2017; lncRNAs in development and disease: from functions to mechanisms.

E-pub date: 31 Jul 2017; A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 20 Jul 2017; BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

E-pub date: 11 Jul 2017; The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

E-pub date: 22 Mar 2017; TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

E-pub date: 16 Jan 2017; Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

E-pub date: 18 Oct 2016; Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

E-pub date: 15 Jul 2016; One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

E-pub date: 01 Apr 2016; A Happy 3′ Ending to the piRNA Maturation Story.

E-pub date: 25 Feb 2016; Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

E-pub date: 04 Feb 2016; Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

E-pub date: 04 Jan 2016; The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

E-pub date: 01 Nov 2015; Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

E-pub date: 01 Nov 2015; Correction for Dequéant et al., Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 31 Oct 2015; Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 20 Oct 2015; Panoramix enforces piRNA-dependent cotranscriptional silencing.

E-pub date: 16 Oct 2015; Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

E-pub date: 06 Oct 2015; Biochemical isolation of Argonaute protein complexes by Ago-APP.

E-pub date: 22 Sep 2015; RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

E-pub date: 01 Jul 2015; ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

E-pub date: 31 May 2015; An epigenetic memory of pregnancy in the mouse mammary gland.

E-pub date: 19 May 2015; piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

E-pub date: 15 May 2015; A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

E-pub date: 16 Apr 2015; Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

E-pub date: 23 Mar 2015; Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

E-pub date: 01 Feb 2015; A computational algorithm to predict shRNA potency.

E-pub date: 18 Dec 2014; MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

E-pub date: 15 Nov 2014; Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

E-pub date: 03 Nov 2014; A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

E-pub date: 31 Oct 2014; Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

E-pub date: 04 Sep 2014; Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

E-pub date: 17 Jul 2014; Two waves of de novo methylation during mouse germ cell development.

E-pub date: 15 Jul 2014; Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

E-pub date: 01 May 2014; Inducing RNAi in Drosophila cells by soaking with dsRNA.

E-pub date: 01 May 2014; A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

E-pub date: 01 Apr 2014; An atlas of chromatoid body components.

E-pub date: 01 Apr 2014; De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

E-pub date: 31 Oct 2013; Patient-derived tumor xenografts: transforming clinical samples into mouse models.

E-pub date: 01 Sep 2013; Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

E-pub date: 01 Sep 2013; A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

E-pub date: 31 Aug 2013; Minotaur is critical for primary piRNA biogenesis.

E-pub date: 31 Aug 2013; Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

E-pub date: 31 Aug 2013; Dicer-2 processes diverse viral RNA species.

E-pub date: 31 Aug 2013; Infection of mammalian cells with retroviral shRNAs.

E-pub date: 31 Jul 2013; Packaging shRNA retroviruses.

E-pub date: 31 Jul 2013; Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.

E-pub date: 15 Jul 2013; Creating an miR30-based shRNA vector.

E-pub date: 01 Jul 2013; The making of a slicer: activation of human Argonaute-1.

E-pub date: 27 Jun 2013; A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

E-pub date: 06 Jun 2013; A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

E-pub date: 06 Jun 2013; DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

E-pub date: 28 May 2013; Dnmt2-dependent methylomes lack defined DNA methylation patterns.

E-pub date: 21 May 2013; Inducing RNAi in Drosophila cells by transfection with dsRNA.

E-pub date: 01 May 2013; Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

E-pub date: 30 Apr 2013; Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

E-pub date: 05 Apr 2013; Dogma derailed: the many influences of RNA on the genome.

E-pub date: 07 Mar 2013; Multiple roles for Piwi in silencing Drosophila transposons.

E-pub date: 15 Feb 2013; The piRNA pathway in flies: highlights and future directions.

E-pub date: 01 Feb 2013; Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

E-pub date: 01 Dec 2012; Site identification in high-throughput RNA-protein interaction data.

E-pub date: 01 Dec 2012; The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

E-pub date: 08 Nov 2012; Unique small RNA signatures uncovered in the tammar wallaby genome.

E-pub date: 17 Oct 2012; Preparation of small RNA libraries for high-throughput sequencing.

E-pub date: 01 Oct 2012; An integrated encyclopedia of DNA elements in the human genome.

E-pub date: 06 Sep 2012; Landscape of transcription in human cells.

E-pub date: 06 Sep 2012; RNAi in cultured mammalian cells using synthetic siRNAs.

E-pub date: 01 Sep 2012; shutdown is a component of the Drosophila piRNA biogenesis machinery.

E-pub date: 31 Aug 2012; Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

E-pub date: 31 Aug 2012; MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

E-pub date: 31 Aug 2012; Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

E-pub date: 31 Aug 2012; The structure of human argonaute-2 in complex with miR-20a.

E-pub date: 06 Jul 2012; Genomic landscape of human allele-specific DNA methylation.

E-pub date: 08 May 2012; Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

E-pub date: 01 Apr 2012; Production of transgenic calves expressing an shRNA targeting myostatin.

E-pub date: 31 Mar 2012; An alternative mode of microRNA target recognition.

E-pub date: 12 Feb 2012; A pipeline for the generation of shRNA transgenic mice.

E-pub date: 02 Feb 2012; Production of artificial piRNAs in flies and mice.

E-pub date: 31 Jan 2012; Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

E-pub date: 17 Jan 2012; Cell-type-based analysis of microRNA profiles in the mouse brain.

E-pub date: 12 Jan 2012; Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).

E-pub date: 01 Dec 2011; Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

E-pub date: 01 Nov 2011; miR-34 miRNAs provide a barrier for somatic cell reprogramming.

E-pub date: 23 Oct 2011; Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

E-pub date: 07 Oct 2011; Ancestral roles of small RNAs: an Ago-centric perspective.

E-pub date: 01 Oct 2011; Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.

E-pub date: 16 Sep 2011; Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

E-pub date: 01 Sep 2011; Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

E-pub date: 01 Sep 2011; Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

E-pub date: 01 Sep 2011; piRNA production requires heterochromatin formation in Drosophila.

E-pub date: 23 Aug 2011; Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

E-pub date: 28 Jun 2011; A genome-scale shRNA resource for transgenic RNAi in Drosophila.

E-pub date: 31 May 2011; Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

E-pub date: 31 May 2011; Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

E-pub date: 19 May 2011; A rapid and scalable system for studying gene function in mice using conditional RNA interference.

E-pub date: 01 Apr 2011; A user’s guide to the encyclopedia of DNA elements (ENCODE).

E-pub date: 01 Apr 2011; Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

E-pub date: 25 Mar 2011; FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

E-pub date: 24 Mar 2011; Silencing of microRNA families by seed-targeting tiny LNAs.

E-pub date: 20 Mar 2011; Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

E-pub date: 18 Mar 2011; Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

E-pub date: 01 Feb 2011; Small RNA sorting: matchmaking for Argonautes.

E-pub date: 31 Jan 2011; Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

E-pub date: 31 Jan 2011; Identification of functional elements and regulatory circuits by Drosophila modENCODE.

E-pub date: 30 Nov 2010; Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.

E-pub date: 15 Nov 2010; Canonical and alternate functions of the microRNA biogenesis machinery.

E-pub date: 01 Sep 2010; Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.

E-pub date: 31 Aug 2010; Targeted enrichment of specific regions in the human genome by array hybridization.

E-pub date: 31 Jul 2010; Enrichment of poly(A)+ mRNA using immobilized oligo(dT).

E-pub date: 30 Jun 2010; Guidelines for the use of RNA purification kits.

E-pub date: 30 Jun 2010; A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.

E-pub date: 25 Jun 2010; Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

E-pub date: 25 Jun 2010; A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

E-pub date: 03 Jun 2010; Nondenaturing agarose gel electrophoresis of RNA.

E-pub date: 01 Jun 2010; Removal of ribosomal subunits (and rRNA) from cytoplasmic extracts before solubilization with SDS and deproteinization.

E-pub date: 01 Jun 2010; Ethanol precipitation of RNA and the use of carriers.

E-pub date: 01 Jun 2010; Determining the yield and quality of purified RNA.

E-pub date: 01 Jun 2010; Preparation of cytoplasmic and nuclear RNA from tissue culture cells.

E-pub date: 01 Jun 2010; Purification of RNA by SDS solubilization and phenol extraction.

E-pub date: 01 Jun 2010; Removal of DNA from RNA.

E-pub date: 01 Jun 2010; Purification of RNA using TRIzol (TRI reagent).

E-pub date: 01 Jun 2010; Polyacrylamide gel electrophoresis of RNA.

E-pub date: 01 Jun 2010; Targeted investigation of the Neandertal genome by array-based sequence capture.

E-pub date: 07 May 2010; Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

E-pub date: 02 Apr 2010; Ancient animal microRNAs and the evolution of tissue identity.

E-pub date: 25 Feb 2010; Compressed Genotyping.

E-pub date: 01 Feb 2010; Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

E-pub date: 31 Jan 2010; Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation.

E-pub date: 31 Jan 2010; The CRISPR system: small RNA-guided defense in bacteria and archaea.

E-pub date: 15 Jan 2010; The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

E-pub date: 01 Jan 2010; Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

E-pub date: 31 Dec 2009; miR-19 is a key oncogenic component of mir-17-92.

E-pub date: 15 Dec 2009; Arginine methylation as a molecular signature of the Piwi small RNA pathway.

E-pub date: 15 Dec 2009; Hierarchical rules for Argonaute loading in Drosophila.

E-pub date: 13 Nov 2009; Updates to the RMAP short-read mapping software.

E-pub date: 01 Nov 2009; Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

E-pub date: 31 Oct 2009; Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

E-pub date: 06 Oct 2009; Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

E-pub date: 24 Sep 2009; The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

E-pub date: 15 Sep 2009; Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila.

E-pub date: 01 Sep 2009; High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

E-pub date: 01 Sep 2009; Molecular evolution of piRNA and transposon control pathways in Drosophila.

E-pub date: 31 Aug 2009; Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

E-pub date: 31 Aug 2009; Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.

E-pub date: 15 Aug 2009; Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

E-pub date: 01 Aug 2009; DNA Sudoku–harnessing high-throughput sequencing for multiplexed specimen analysis.

E-pub date: 31 Jul 2009; Cyfip1 is a putative invasion suppressor in epithelial cancers.

E-pub date: 12 Jun 2009; Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

E-pub date: 01 May 2009; Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

E-pub date: 20 Mar 2009; The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

E-pub date: 24 Feb 2009; Small RNAs as guardians of the genome.

E-pub date: 20 Feb 2009; Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs.

E-pub date: 19 Feb 2009; Design of 240,000 orthogonal 25mer DNA barcode probes.

E-pub date: 17 Feb 2009; miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.

E-pub date: 31 Dec 2008; An epigenetic role for maternally inherited piRNAs in transposon silencing.

E-pub date: 28 Nov 2008; An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

E-pub date: 28 Nov 2008; Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

E-pub date: 21 Nov 2008; A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

E-pub date: 26 Sep 2008; A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 01 Sep 2008; Small RNA silencing pathways in germ and stem cells.

E-pub date: 31 Aug 2008; Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.

E-pub date: 31 Aug 2008; Topoisomerase levels determine chemotherapy response in vitro and in vivo.

E-pub date: 01 Jul 2008; An endogenous small interfering RNA pathway in Drosophila.

E-pub date: 05 Jun 2008; Conservation of small RNA pathways in platypus.

E-pub date: 01 Jun 2008; Astrin regulates Aurora-A localization.

E-pub date: 30 May 2008; Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

E-pub date: 22 May 2008; Genome analysis of the platypus reveals unique signatures of evolution.

E-pub date: 08 May 2008; Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

E-pub date: 22 Apr 2008; Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5′ terminal nucleotide.

E-pub date: 04 Apr 2008; A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 31 Mar 2008; Conserved themes in small-RNA-mediated transposon control.

E-pub date: 31 Mar 2008; Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

E-pub date: 12 Feb 2008; Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

E-pub date: 01 Feb 2008; Cancer proliferation gene discovery through functional genomics.

E-pub date: 01 Feb 2008; Profiling essential genes in human mammary cells by multiplex RNAi screening.

E-pub date: 01 Feb 2008; Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

E-pub date: 01 Jan 2008; Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.

E-pub date: 31 Dec 2007; Genome-wide in situ exon capture for selective resequencing.

E-pub date: 31 Dec 2007; A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

E-pub date: 15 Dec 2007; A biochemical approach to identifying microRNA targets.

E-pub date: 04 Dec 2007; The guardian’s little helper: microRNAs in the p53 tumor suppressor network.

E-pub date: 01 Dec 2007; Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.

E-pub date: 08 Nov 2007; The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.

E-pub date: 02 Nov 2007; microRNAs join the p53 network–another piece in the tumour-suppression puzzle.

E-pub date: 01 Nov 2007; A MicroRNA feedback circuit in midbrain dopamine neurons.

E-pub date: 31 Aug 2007; [The role of piRNAs in mouse spermatogenesis.].

E-pub date: 31 Aug 2007; Tissue-specific and reversible RNA interference in transgenic mice.

E-pub date: 31 Jul 2007; A microRNA component of the p53 tumour suppressor network.

E-pub date: 28 Jun 2007; A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

E-pub date: 31 May 2007; A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

E-pub date: 15 May 2007; Developmentally regulated piRNA clusters implicate MILI in transposon control.

E-pub date: 04 May 2007; Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

E-pub date: 19 Apr 2007; A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

E-pub date: 06 Apr 2007; MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

E-pub date: 01 Apr 2007; Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

E-pub date: 23 Mar 2007; Critical roles for Dicer in the female germline.

E-pub date: 15 Mar 2007; Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

E-pub date: 31 May 2003; A survey of canine expressed sequence tags and a display of their annotations through a flexible web-based interface.

E-pub date: 01 Jan 2003; The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

E-pub date: 30 Nov 2002; Oncogenic ras and p53 cooperate to induce cellular senescence.

E-pub date: 01 May 2002; Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

E-pub date: 31 May 2000; A proinflammatory cytokine inhibits p53 tumor suppressor activity.

E-pub date: 31 Oct 1999; Twist is a potential oncogene that inhibits apoptosis.

E-pub date: 31 Aug 1999; MaRX: an approach to genetics in mammalian cells.

E-pub date: 31 Jan 1999; p53-independent role of MDM2 in TGF-beta1 resistance.

E-pub date: 30 Nov 1998; Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.

E-pub date: 31 Oct 1998; Oncogene-dependent apoptosis is mediated by caspase-9.

E-pub date: 31 Oct 1998; The INK4 family of CDK inhibitors.

E-pub date: 01 Aug 1998; Myc activates telomerase.

E-pub date: 31 May 1998; Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

E-pub date: 31 Oct 1996; Shared role of the pRB-related p130 and p107 proteins in limb development.

E-pub date: 30 Jun 1996; Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 –> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

E-pub date: 31 May 1996; Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage.

E-pub date: 31 Jan 1996; Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.

E-pub date: 01 Oct 1995; Deletion of the p16 and p15 genes in human bladder tumors.

E-pub date: 30 Sep 1995; p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

E-pub date: 31 Mar 1995; Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

E-pub date: 31 Jan 1995; p21 is a component of active cell cycle kinases.

E-pub date: 01 Aug 1994; p21-containing cyclin kinases exist in both active and inactive states.

E-pub date: 31 Jul 1994; Construction of an improved host strain for two hybrid screening.

E-pub date: 31 Mar 1994; KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

E-pub date: 28 Feb 1994; Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

E-pub date: 01 Dec 1993; Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing.

E-pub date: 30 Nov 1992; Trans splicing of nematode pre-messenger RNA in vitro.

E-pub date: 31 May 1990; Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system.

E-pub date: 01 Jan 1990; Accurate processing of human pre-rRNA in vitro.

E-pub date: 01 Oct 1989; Accurate and efficient RNA polymerase III transcription in a cell-free extract prepared from Ascaris suum embryos.

E-pub date: 01 Jul 1989; Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi.

E-pub date: 30 Apr 1989; Show all Hide all

Research Integrity Conflict of Interest Disclosure:

Last revised:: 12/09/2018

Company	Active	Research funding	Ownership	Royalty payments	Commitment to carry out work for a fee	Ad hoc reimbursed work	Travel	Gifts/ other
Transomics	Yes	No	Yes	Yes	Yes	No	No	No
Suil Interactive	Yes	No	Yes	No	No	No	No	No
Regulus	Yes	No	Yes	No	Yes	No	No	No
RxI Pharma	Yes	No	Yes	No	No	No	No	No
Cold Spring Harbor Laboratory	Yes	No	No	Yes	No	No	No	Yes
Mirimus	Yes	No	No	No	No	No	No	No
Faeth Therapeutics	No	No	No	No	No	No	No	No

Disclosure guidelines

Greg Hannon

Director of the CRI

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

Genetic interactions of G-quadruplexes in humans.

piRNA-guided co-transcriptional silencing coopts nuclear export factors.

Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.

lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.

piRNA-Guided Genome Defense: From Biogenesis to Silencing.

Corrigendum to “GoldCLIP: Gel-omitted Ligation-dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

GoldCLIP: Gel-omitted Ligation-dependent CLIP.

Asparagine bioavailability governs metastasis in a model of breast cancer.

Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

A Model for Epigenetic Inhibition via Transvection in the Mouse.

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

lncRNAs in development and disease: from functions to mechanisms.

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

A Happy 3′ Ending to the piRNA Maturation Story.

Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

Correction for Dequéant et al., Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

Panoramix enforces piRNA-dependent cotranscriptional silencing.

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

Biochemical isolation of Argonaute protein complexes by Ago-APP.

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

An epigenetic memory of pregnancy in the mouse mammary gland.

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

A computational algorithm to predict shRNA potency.

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

Two waves of de novo methylation during mouse germ cell development.

Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

Inducing RNAi in Drosophila cells by soaking with dsRNA.

A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

An atlas of chromatoid body components.

De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

Patient-derived tumor xenografts: transforming clinical samples into mouse models.

Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

Minotaur is critical for primary piRNA biogenesis.

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

Dicer-2 processes diverse viral RNA species.

Infection of mammalian cells with retroviral shRNAs.

Packaging shRNA retroviruses.

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.

Creating an miR30-based shRNA vector.

The making of a slicer: activation of human Argonaute-1.

A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Inducing RNAi in Drosophila cells by transfection with dsRNA.

Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

Dogma derailed: the many influences of RNA on the genome.

Multiple roles for Piwi in silencing Drosophila transposons.

The piRNA pathway in flies: highlights and future directions.

Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

Site identification in high-throughput RNA-protein interaction data.

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

Unique small RNA signatures uncovered in the tammar wallaby genome.

Preparation of small RNA libraries for high-throughput sequencing.