Director, Senior Group Leader

Research Group Home Page: 
Hannon Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

piRNA-Guided Genome Defense: From Biogenesis to Silencing.

E-pub date: 31 Oct 2018


Corrigendum to “GoldCLIP: Gel-omitted Ligation-dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

E-pub date: 01 Jun 2018


COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

E-pub date: 02 Apr 2018


GoldCLIP: Gel-omitted Ligation-dependent CLIP.

E-pub date: 01 Apr 2018


Asparagine bioavailability governs metastasis in a model of breast cancer.

E-pub date: 15 Feb 2018


Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

E-pub date: 01 Feb 2018


lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

E-pub date: 06 Sep 2017


A Model for Epigenetic Inhibition via Transvection in the Mouse.

E-pub date: 01 Sep 2017


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 31 Aug 2017


lncRNAs in development and disease: from functions to mechanisms.

E-pub date: 31 Jul 2017


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 20 Jul 2017


BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

E-pub date: 11 Jul 2017


The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

E-pub date: 22 Mar 2017


TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

E-pub date: 16 Jan 2017


Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

E-pub date: 18 Oct 2016


Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

E-pub date: 15 Jul 2016


One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

E-pub date: 01 Apr 2016


A Happy 3′ Ending to the piRNA Maturation Story.

E-pub date: 25 Feb 2016


Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

E-pub date: 04 Feb 2016


Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

E-pub date: 04 Jan 2016


The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

E-pub date: 01 Nov 2015


Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

E-pub date: 01 Nov 2015


Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 20 Oct 2015


Panoramix enforces piRNA-dependent cotranscriptional silencing.

E-pub date: 16 Oct 2015


Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

E-pub date: 06 Oct 2015


Biochemical isolation of Argonaute protein complexes by Ago-APP.

E-pub date: 22 Sep 2015


RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

E-pub date: 01 Jul 2015


ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

E-pub date: 31 May 2015


An epigenetic memory of pregnancy in the mouse mammary gland.

E-pub date: 19 May 2015


piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

E-pub date: 15 May 2015


A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

E-pub date: 16 Apr 2015


Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

E-pub date: 23 Mar 2015


Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

E-pub date: 01 Feb 2015


A computational algorithm to predict shRNA potency.

E-pub date: 18 Dec 2014


MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

E-pub date: 15 Nov 2014


Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

E-pub date: 03 Nov 2014


A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

E-pub date: 31 Oct 2014


Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

E-pub date: 04 Sep 2014


Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

E-pub date: 17 Jul 2014


Two waves of de novo methylation during mouse germ cell development.

E-pub date: 15 Jul 2014


Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

E-pub date: 01 May 2014


Inducing RNAi in Drosophila cells by soaking with dsRNA.

E-pub date: 01 May 2014


A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

E-pub date: 01 Apr 2014


An atlas of chromatoid body components.

E-pub date: 01 Apr 2014


De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

E-pub date: 31 Oct 2013


Patient-derived tumor xenografts: transforming clinical samples into mouse models.

E-pub date: 01 Sep 2013


Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

E-pub date: 01 Sep 2013


A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

E-pub date: 31 Aug 2013


Minotaur is critical for primary piRNA biogenesis.

E-pub date: 31 Aug 2013


Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

E-pub date: 31 Aug 2013


Dicer-2 processes diverse viral RNA species.

E-pub date: 31 Aug 2013


Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.

E-pub date: 15 Jul 2013


Creating an miR30-based shRNA vector.

E-pub date: 01 Jul 2013


The making of a slicer: activation of human Argonaute-1.

E-pub date: 27 Jun 2013


A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

E-pub date: 06 Jun 2013


A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

E-pub date: 06 Jun 2013


DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

E-pub date: 28 May 2013


Dnmt2-dependent methylomes lack defined DNA methylation patterns.

E-pub date: 21 May 2013


Inducing RNAi in Drosophila cells by transfection with dsRNA.

E-pub date: 01 May 2013


Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

E-pub date: 30 Apr 2013


Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

E-pub date: 05 Apr 2013


Dogma derailed: the many influences of RNA on the genome.

E-pub date: 07 Mar 2013


Multiple roles for Piwi in silencing Drosophila transposons.

E-pub date: 15 Feb 2013


The piRNA pathway in flies: highlights and future directions.

E-pub date: 01 Feb 2013


Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

E-pub date: 01 Dec 2012


Site identification in high-throughput RNA-protein interaction data.

E-pub date: 01 Dec 2012


The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

E-pub date: 08 Nov 2012


Unique small RNA signatures uncovered in the tammar wallaby genome.

E-pub date: 17 Oct 2012


Preparation of small RNA libraries for high-throughput sequencing.

E-pub date: 01 Oct 2012


An integrated encyclopedia of DNA elements in the human genome.

E-pub date: 06 Sep 2012


Landscape of transcription in human cells.

E-pub date: 06 Sep 2012


RNAi in cultured mammalian cells using synthetic siRNAs.

E-pub date: 01 Sep 2012


shutdown is a component of the Drosophila piRNA biogenesis machinery.

E-pub date: 31 Aug 2012


Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

E-pub date: 31 Aug 2012


MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

E-pub date: 31 Aug 2012


Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

E-pub date: 31 Aug 2012


The structure of human argonaute-2 in complex with miR-20a.

E-pub date: 06 Jul 2012


Genomic landscape of human allele-specific DNA methylation.

E-pub date: 08 May 2012


Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

E-pub date: 01 Apr 2012


Production of transgenic calves expressing an shRNA targeting myostatin.

E-pub date: 31 Mar 2012


An alternative mode of microRNA target recognition.

E-pub date: 12 Feb 2012


A pipeline for the generation of shRNA transgenic mice.

E-pub date: 02 Feb 2012


Production of artificial piRNAs in flies and mice.

E-pub date: 31 Jan 2012


Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

E-pub date: 17 Jan 2012


Cell-type-based analysis of microRNA profiles in the mouse brain.

E-pub date: 12 Jan 2012


Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

E-pub date: 01 Nov 2011


miR-34 miRNAs provide a barrier for somatic cell reprogramming.

E-pub date: 23 Oct 2011


Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

E-pub date: 07 Oct 2011


Ancestral roles of small RNAs: an Ago-centric perspective.

E-pub date: 01 Oct 2011


Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.

E-pub date: 16 Sep 2011


Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

E-pub date: 01 Sep 2011


Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

E-pub date: 01 Sep 2011


Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

E-pub date: 01 Sep 2011


piRNA production requires heterochromatin formation in Drosophila.

E-pub date: 23 Aug 2011


Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

E-pub date: 28 Jun 2011


A genome-scale shRNA resource for transgenic RNAi in Drosophila.

E-pub date: 31 May 2011


Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

E-pub date: 31 May 2011


Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

E-pub date: 19 May 2011


A rapid and scalable system for studying gene function in mice using conditional RNA interference.

E-pub date: 01 Apr 2011


Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

E-pub date: 25 Mar 2011


FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

E-pub date: 24 Mar 2011


Silencing of microRNA families by seed-targeting tiny LNAs.

E-pub date: 20 Mar 2011


Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

E-pub date: 18 Mar 2011


Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

E-pub date: 01 Feb 2011


Small RNA sorting: matchmaking for Argonautes.

E-pub date: 31 Jan 2011


Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

E-pub date: 31 Jan 2011


Identification of functional elements and regulatory circuits by Drosophila modENCODE.

E-pub date: 24 Dec 2010


Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.

E-pub date: 15 Nov 2010


Canonical and alternate functions of the microRNA biogenesis machinery.

E-pub date: 01 Sep 2010


Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.

E-pub date: 31 Aug 2010


Targeted enrichment of specific regions in the human genome by array hybridization.

E-pub date: 31 Jul 2010


A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.

E-pub date: 25 Jun 2010


Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

E-pub date: 25 Jun 2010


A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

E-pub date: 03 Jun 2010


Targeted investigation of the Neandertal genome by array-based sequence capture.

E-pub date: 07 May 2010


Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

E-pub date: 02 Apr 2010


Ancient animal microRNAs and the evolution of tissue identity.

E-pub date: 25 Feb 2010


Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

E-pub date: 31 Jan 2010


Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation.

E-pub date: 31 Jan 2010


The CRISPR system: small RNA-guided defense in bacteria and archaea.

E-pub date: 15 Jan 2010


The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

E-pub date: 01 Jan 2010


Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

E-pub date: 31 Dec 2009


miR-19 is a key oncogenic component of mir-17-92.

E-pub date: 15 Dec 2009


Arginine methylation as a molecular signature of the Piwi small RNA pathway.

E-pub date: 15 Dec 2009


Hierarchical rules for Argonaute loading in Drosophila.

E-pub date: 13 Nov 2009


Updates to the RMAP short-read mapping software.

E-pub date: 01 Nov 2009


Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

E-pub date: 31 Oct 2009


Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

E-pub date: 06 Oct 2009


Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

E-pub date: 24 Sep 2009


The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

E-pub date: 15 Sep 2009


Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila.

E-pub date: 01 Sep 2009


High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

E-pub date: 01 Sep 2009


Molecular evolution of piRNA and transposon control pathways in Drosophila.

E-pub date: 31 Aug 2009


Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

E-pub date: 31 Aug 2009


Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.

E-pub date: 15 Aug 2009


Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

E-pub date: 01 Aug 2009


DNA Sudoku–harnessing high-throughput sequencing for multiplexed specimen analysis.

E-pub date: 31 Jul 2009


Cyfip1 is a putative invasion suppressor in epithelial cancers.

E-pub date: 12 Jun 2009


Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

E-pub date: 01 May 2009


Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

E-pub date: 20 Mar 2009


The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

E-pub date: 24 Feb 2009


Small RNAs as guardians of the genome.

E-pub date: 20 Feb 2009


Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs.

E-pub date: 19 Feb 2009


Design of 240,000 orthogonal 25mer DNA barcode probes.

E-pub date: 17 Feb 2009


miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.

E-pub date: 31 Dec 2008


An epigenetic role for maternally inherited piRNAs in transposon silencing.

E-pub date: 28 Nov 2008


An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

E-pub date: 28 Nov 2008


Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

E-pub date: 21 Nov 2008


A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

E-pub date: 26 Sep 2008


Small RNA silencing pathways in germ and stem cells.

E-pub date: 31 Aug 2008


Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.

E-pub date: 31 Aug 2008


Topoisomerase levels determine chemotherapy response in vitro and in vivo.

E-pub date: 01 Jul 2008


An endogenous small interfering RNA pathway in Drosophila.

E-pub date: 05 Jun 2008


Conservation of small RNA pathways in platypus.

E-pub date: 01 Jun 2008


Astrin regulates Aurora-A localization.

E-pub date: 30 May 2008


Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

E-pub date: 22 May 2008


Genome analysis of the platypus reveals unique signatures of evolution.

E-pub date: 08 May 2008


Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

E-pub date: 22 Apr 2008


Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5′ terminal nucleotide.

E-pub date: 04 Apr 2008


A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 31 Mar 2008


Conserved themes in small-RNA-mediated transposon control.

E-pub date: 31 Mar 2008


Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

E-pub date: 12 Feb 2008


Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

E-pub date: 01 Feb 2008


Cancer proliferation gene discovery through functional genomics.

E-pub date: 01 Feb 2008


Profiling essential genes in human mammary cells by multiplex RNAi screening.

E-pub date: 01 Feb 2008


Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

E-pub date: 01 Jan 2008


Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.

E-pub date: 31 Dec 2007


Genome-wide in situ exon capture for selective resequencing.

E-pub date: 31 Dec 2007


A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

E-pub date: 15 Dec 2007


A biochemical approach to identifying microRNA targets.

E-pub date: 04 Dec 2007


The guardian’s little helper: microRNAs in the p53 tumor suppressor network.

E-pub date: 01 Dec 2007


Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.

E-pub date: 08 Nov 2007


The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.

E-pub date: 02 Nov 2007


microRNAs join the p53 network–another piece in the tumour-suppression puzzle.

E-pub date: 01 Nov 2007


A MicroRNA feedback circuit in midbrain dopamine neurons.

E-pub date: 31 Aug 2007


[The role of piRNAs in mouse spermatogenesis.].

E-pub date: 31 Aug 2007


Tissue-specific and reversible RNA interference in transgenic mice.

E-pub date: 31 Jul 2007


A microRNA component of the p53 tumour suppressor network.

E-pub date: 28 Jun 2007


A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

E-pub date: 31 May 2007


A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

E-pub date: 15 May 2007


Developmentally regulated piRNA clusters implicate MILI in transposon control.

E-pub date: 04 May 2007


Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

E-pub date: 19 Apr 2007


A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

E-pub date: 06 Apr 2007


MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

E-pub date: 01 Apr 2007


Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

E-pub date: 23 Mar 2007


Critical roles for Dicer in the female germline.

E-pub date: 15 Mar 2007


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
12/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
Transomics Yes No Yes Yes Yes No No No
Suil Interactive Yes No Yes No No No No No
Regulus Yes No Yes No Yes No No No
RxI Pharma Yes No Yes No No No No No
Cold Spring Harbor Laboratory Yes No No Yes No No No Yes
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