Director of the CRI

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

E-pub date: 31 Oct 2019

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

E-pub date: 31 Jul 2019

Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019

piRNA-guided co-transcriptional silencing coopts nuclear export factors.

E-pub date: 31 May 2019

Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.

E-pub date: 30 Apr 2019

lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.

E-pub date: 31 Mar 2019

piRNA-Guided Genome Defense: From Biogenesis to Silencing.

E-pub date: 31 Oct 2018

Corrigendum to “GoldCLIP: Gel-omitted Ligation-dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

E-pub date: 01 Jun 2018

Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

E-pub date: 01 Jun 2018

COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

E-pub date: 02 Apr 2018

GoldCLIP: Gel-omitted Ligation-dependent CLIP.

E-pub date: 01 Apr 2018

Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer.

E-pub date: 31 Mar 2018

Asparagine bioavailability governs metastasis in a model of breast cancer.

E-pub date: 15 Feb 2018

Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

E-pub date: 01 Feb 2018

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

E-pub date: 06 Sep 2017

A Model for Epigenetic Inhibition via Transvection in the Mouse.

E-pub date: 01 Sep 2017

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 31 Aug 2017

lncRNAs in development and disease: from functions to mechanisms.

E-pub date: 31 Jul 2017

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 20 Jul 2017

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

E-pub date: 11 Jul 2017

The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

E-pub date: 22 Mar 2017

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

E-pub date: 16 Jan 2017

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

E-pub date: 18 Oct 2016

Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

E-pub date: 15 Jul 2016

One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

E-pub date: 01 Apr 2016

A Happy 3′ Ending to the piRNA Maturation Story.

E-pub date: 25 Feb 2016

Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

E-pub date: 04 Feb 2016

Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

E-pub date: 04 Jan 2016

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

E-pub date: 01 Nov 2015

Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

E-pub date: 01 Nov 2015

Correction for Dequéant et al., Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 31 Oct 2015

Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 20 Oct 2015

Panoramix enforces piRNA-dependent cotranscriptional silencing.

E-pub date: 16 Oct 2015

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

E-pub date: 06 Oct 2015

Biochemical isolation of Argonaute protein complexes by Ago-APP.

E-pub date: 22 Sep 2015

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

E-pub date: 01 Jul 2015

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

E-pub date: 31 May 2015

An epigenetic memory of pregnancy in the mouse mammary gland.

E-pub date: 19 May 2015

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

E-pub date: 15 May 2015

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

E-pub date: 16 Apr 2015

Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

E-pub date: 23 Mar 2015

Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

E-pub date: 01 Feb 2015

A computational algorithm to predict shRNA potency.

E-pub date: 18 Dec 2014

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

E-pub date: 15 Nov 2014

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

E-pub date: 03 Nov 2014

A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

E-pub date: 31 Oct 2014

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

E-pub date: 04 Sep 2014

Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

E-pub date: 17 Jul 2014

Two waves of de novo methylation during mouse germ cell development.

E-pub date: 15 Jul 2014

Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

E-pub date: 01 May 2014

Inducing RNAi in Drosophila cells by soaking with dsRNA.

E-pub date: 01 May 2014

A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

E-pub date: 01 Apr 2014

An atlas of chromatoid body components.

E-pub date: 01 Apr 2014

De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

E-pub date: 31 Oct 2013

Patient-derived tumor xenografts: transforming clinical samples into mouse models.

E-pub date: 01 Sep 2013

Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

E-pub date: 01 Sep 2013

A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

E-pub date: 31 Aug 2013

Minotaur is critical for primary piRNA biogenesis.

E-pub date: 31 Aug 2013

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

E-pub date: 31 Aug 2013

Dicer-2 processes diverse viral RNA species.

E-pub date: 31 Aug 2013

Infection of mammalian cells with retroviral shRNAs.

E-pub date: 31 Jul 2013

Packaging shRNA retroviruses.

E-pub date: 31 Jul 2013

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.

E-pub date: 15 Jul 2013

Creating an miR30-based shRNA vector.

E-pub date: 01 Jul 2013

The making of a slicer: activation of human Argonaute-1.

E-pub date: 27 Jun 2013

A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

E-pub date: 06 Jun 2013

A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

E-pub date: 06 Jun 2013

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

E-pub date: 28 May 2013

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

E-pub date: 21 May 2013

Inducing RNAi in Drosophila cells by transfection with dsRNA.

E-pub date: 01 May 2013

Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

E-pub date: 30 Apr 2013

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

E-pub date: 05 Apr 2013

Dogma derailed: the many influences of RNA on the genome.

E-pub date: 07 Mar 2013

Multiple roles for Piwi in silencing Drosophila transposons.

E-pub date: 15 Feb 2013

The piRNA pathway in flies: highlights and future directions.

E-pub date: 01 Feb 2013

Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

E-pub date: 01 Dec 2012

Site identification in high-throughput RNA-protein interaction data.

E-pub date: 01 Dec 2012

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

E-pub date: 08 Nov 2012

Unique small RNA signatures uncovered in the tammar wallaby genome.

E-pub date: 17 Oct 2012

Preparation of small RNA libraries for high-throughput sequencing.

E-pub date: 01 Oct 2012

An integrated encyclopedia of DNA elements in the human genome.

E-pub date: 06 Sep 2012

Landscape of transcription in human cells.

E-pub date: 06 Sep 2012

RNAi in cultured mammalian cells using synthetic siRNAs.

E-pub date: 01 Sep 2012

shutdown is a component of the Drosophila piRNA biogenesis machinery.

E-pub date: 31 Aug 2012

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

E-pub date: 31 Aug 2012

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

E-pub date: 31 Aug 2012

Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

E-pub date: 31 Aug 2012

The structure of human argonaute-2 in complex with miR-20a.

E-pub date: 06 Jul 2012

Genomic landscape of human allele-specific DNA methylation.

E-pub date: 08 May 2012

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

E-pub date: 01 Apr 2012

Production of transgenic calves expressing an shRNA targeting myostatin.

E-pub date: 31 Mar 2012

An alternative mode of microRNA target recognition.

E-pub date: 12 Feb 2012

A pipeline for the generation of shRNA transgenic mice.

E-pub date: 02 Feb 2012

Production of artificial piRNAs in flies and mice.

E-pub date: 31 Jan 2012

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

E-pub date: 17 Jan 2012

Cell-type-based analysis of microRNA profiles in the mouse brain.

E-pub date: 12 Jan 2012

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).

E-pub date: 01 Dec 2011

Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

E-pub date: 01 Nov 2011

miR-34 miRNAs provide a barrier for somatic cell reprogramming.

E-pub date: 23 Oct 2011

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

E-pub date: 07 Oct 2011

Ancestral roles of small RNAs: an Ago-centric perspective.

E-pub date: 01 Oct 2011

Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.

E-pub date: 16 Sep 2011

Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

E-pub date: 01 Sep 2011

Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

E-pub date: 01 Sep 2011

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

E-pub date: 01 Sep 2011

piRNA production requires heterochromatin formation in Drosophila.

E-pub date: 23 Aug 2011

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

E-pub date: 28 Jun 2011

A genome-scale shRNA resource for transgenic RNAi in Drosophila.

E-pub date: 31 May 2011

Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

E-pub date: 31 May 2011

Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

E-pub date: 19 May 2011

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

E-pub date: 01 Apr 2011

A user’s guide to the encyclopedia of DNA elements (ENCODE).

E-pub date: 01 Apr 2011

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

E-pub date: 25 Mar 2011

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

E-pub date: 24 Mar 2011

Silencing of microRNA families by seed-targeting tiny LNAs.

E-pub date: 20 Mar 2011

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

E-pub date: 18 Mar 2011

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

E-pub date: 01 Feb 2011

Small RNA sorting: matchmaking for Argonautes.

E-pub date: 31 Jan 2011

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

E-pub date: 31 Jan 2011

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

E-pub date: 30 Nov 2010

Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.

E-pub date: 15 Nov 2010

Canonical and alternate functions of the microRNA biogenesis machinery.

E-pub date: 01 Sep 2010

Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.

E-pub date: 31 Aug 2010

Targeted enrichment of specific regions in the human genome by array hybridization.

E-pub date: 31 Jul 2010

Enrichment of poly(A)+ mRNA using immobilized oligo(dT).

E-pub date: 30 Jun 2010

Guidelines for the use of RNA purification kits.

E-pub date: 30 Jun 2010

A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.

E-pub date: 25 Jun 2010

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

E-pub date: 25 Jun 2010

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

E-pub date: 03 Jun 2010

Nondenaturing agarose gel electrophoresis of RNA.

E-pub date: 01 Jun 2010

Removal of ribosomal subunits (and rRNA) from cytoplasmic extracts before solubilization with SDS and deproteinization.

E-pub date: 01 Jun 2010

Ethanol precipitation of RNA and the use of carriers.

E-pub date: 01 Jun 2010

Determining the yield and quality of purified RNA.

E-pub date: 01 Jun 2010

Preparation of cytoplasmic and nuclear RNA from tissue culture cells.

E-pub date: 01 Jun 2010

Purification of RNA by SDS solubilization and phenol extraction.

E-pub date: 01 Jun 2010

Removal of DNA from RNA.

E-pub date: 01 Jun 2010

Purification of RNA using TRIzol (TRI reagent).

E-pub date: 01 Jun 2010

Polyacrylamide gel electrophoresis of RNA.

E-pub date: 01 Jun 2010

Targeted investigation of the Neandertal genome by array-based sequence capture.

E-pub date: 07 May 2010

Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

E-pub date: 02 Apr 2010

The RNA interference system differently responds to the same mobile element in distant Drosophila species.

E-pub date: 01 Mar 2010

Ancient animal microRNAs and the evolution of tissue identity.

E-pub date: 25 Feb 2010

Compressed Genotyping.

E-pub date: 01 Feb 2010

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

E-pub date: 31 Jan 2010

Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation.

E-pub date: 31 Jan 2010

The CRISPR system: small RNA-guided defense in bacteria and archaea.

E-pub date: 15 Jan 2010

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

E-pub date: 01 Jan 2010

Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

E-pub date: 31 Dec 2009

miR-19 is a key oncogenic component of mir-17-92.

E-pub date: 15 Dec 2009

Arginine methylation as a molecular signature of the Piwi small RNA pathway.

E-pub date: 15 Dec 2009

Hierarchical rules for Argonaute loading in Drosophila.

E-pub date: 13 Nov 2009

Updates to the RMAP short-read mapping software.

E-pub date: 01 Nov 2009

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

E-pub date: 31 Oct 2009

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

E-pub date: 06 Oct 2009

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

E-pub date: 24 Sep 2009

The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

E-pub date: 15 Sep 2009

Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila.

E-pub date: 01 Sep 2009

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

E-pub date: 01 Sep 2009

Molecular evolution of piRNA and transposon control pathways in Drosophila.

E-pub date: 31 Aug 2009

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

E-pub date: 31 Aug 2009

Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.

E-pub date: 15 Aug 2009

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

E-pub date: 01 Aug 2009

DNA Sudoku–harnessing high-throughput sequencing for multiplexed specimen analysis.

E-pub date: 31 Jul 2009

Cyfip1 is a putative invasion suppressor in epithelial cancers.

E-pub date: 12 Jun 2009

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

E-pub date: 01 May 2009

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

E-pub date: 20 Mar 2009

The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

E-pub date: 24 Feb 2009

Small RNAs as guardians of the genome.

E-pub date: 20 Feb 2009

Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs.

E-pub date: 19 Feb 2009

Design of 240,000 orthogonal 25mer DNA barcode probes.

E-pub date: 17 Feb 2009

miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.

E-pub date: 31 Dec 2008

An epigenetic role for maternally inherited piRNAs in transposon silencing.

E-pub date: 28 Nov 2008

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

E-pub date: 28 Nov 2008

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

E-pub date: 21 Nov 2008

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

E-pub date: 26 Sep 2008

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 01 Sep 2008

Small RNA silencing pathways in germ and stem cells.

E-pub date: 31 Aug 2008

Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.

E-pub date: 31 Aug 2008

Analysis of large-scale sequencing of small RNAs.

E-pub date: 01 Aug 2008

Topoisomerase levels determine chemotherapy response in vitro and in vivo.

E-pub date: 01 Jul 2008

An endogenous small interfering RNA pathway in Drosophila.

E-pub date: 05 Jun 2008

Conservation of small RNA pathways in platypus.

E-pub date: 01 Jun 2008

Astrin regulates Aurora-A localization.

E-pub date: 30 May 2008

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

E-pub date: 22 May 2008

Genome analysis of the platypus reveals unique signatures of evolution.

E-pub date: 08 May 2008

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

E-pub date: 22 Apr 2008

Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5′ terminal nucleotide.

E-pub date: 04 Apr 2008

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 31 Mar 2008

Conserved themes in small-RNA-mediated transposon control.

E-pub date: 31 Mar 2008

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

E-pub date: 12 Feb 2008

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

E-pub date: 01 Feb 2008

Cancer proliferation gene discovery through functional genomics.

E-pub date: 01 Feb 2008

Profiling essential genes in human mammary cells by multiplex RNAi screening.

E-pub date: 01 Feb 2008

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

E-pub date: 01 Jan 2008

Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.

E-pub date: 31 Dec 2007

Genome-wide in situ exon capture for selective resequencing.

E-pub date: 31 Dec 2007

A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

E-pub date: 15 Dec 2007

A biochemical approach to identifying microRNA targets.

E-pub date: 04 Dec 2007

The guardian’s little helper: microRNAs in the p53 tumor suppressor network.

E-pub date: 01 Dec 2007

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.

E-pub date: 08 Nov 2007

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.

E-pub date: 02 Nov 2007

microRNAs join the p53 network–another piece in the tumour-suppression puzzle.

E-pub date: 01 Nov 2007

A MicroRNA feedback circuit in midbrain dopamine neurons.

E-pub date: 31 Aug 2007

[The role of piRNAs in mouse spermatogenesis.].

E-pub date: 31 Aug 2007

Tissue-specific and reversible RNA interference in transgenic mice.

E-pub date: 31 Jul 2007

A microRNA component of the p53 tumour suppressor network.

E-pub date: 28 Jun 2007

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

E-pub date: 31 May 2007

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

E-pub date: 15 May 2007

Developmentally regulated piRNA clusters implicate MILI in transposon control.

E-pub date: 04 May 2007

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

E-pub date: 19 Apr 2007

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

E-pub date: 06 Apr 2007

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

E-pub date: 01 Apr 2007

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

E-pub date: 23 Mar 2007

Critical roles for Dicer in the female germline.

E-pub date: 15 Mar 2007

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

E-pub date: 31 May 2003

A survey of canine expressed sequence tags and a display of their annotations through a flexible web-based interface.

E-pub date: 01 Jan 2003

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

E-pub date: 30 Nov 2002

Transformation of normal human cells in the absence of telomerase activation.

E-pub date: 01 Nov 2002

RNA interference: a promising approach to antiviral therapy?

E-pub date: 01 Nov 2002

RNA interference: the new somatic cell genetics?

E-pub date: 01 Jul 2002

Oncogenic ras and p53 cooperate to induce cellular senescence.

E-pub date: 01 May 2002

Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

E-pub date: 31 May 2000

A proinflammatory cytokine inhibits p53 tumor suppressor activity.

E-pub date: 31 Oct 1999

Twist is a potential oncogene that inhibits apoptosis.

E-pub date: 31 Aug 1999

MaRX: an approach to genetics in mammalian cells.

E-pub date: 31 Jan 1999

p53-independent role of MDM2 in TGF-beta1 resistance.

E-pub date: 30 Nov 1998

Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.

E-pub date: 31 Oct 1998

Oncogene-dependent apoptosis is mediated by caspase-9.

E-pub date: 31 Oct 1998

The INK4 family of CDK inhibitors.

E-pub date: 01 Aug 1998

Myc activates telomerase.

E-pub date: 31 May 1998

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

E-pub date: 31 Oct 1996

Shared role of the pRB-related p130 and p107 proteins in limb development.

E-pub date: 30 Jun 1996

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 –> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

E-pub date: 31 May 1996

Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage.

E-pub date: 31 Jan 1996

Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.

E-pub date: 01 Oct 1995

Deletion of the p16 and p15 genes in human bladder tumors.

E-pub date: 30 Sep 1995

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

E-pub date: 31 Mar 1995

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

E-pub date: 31 Jan 1995

p21 is a component of active cell cycle kinases.

E-pub date: 01 Aug 1994

p21-containing cyclin kinases exist in both active and inactive states.

E-pub date: 31 Jul 1994

Construction of an improved host strain for two hybrid screening.

E-pub date: 31 Mar 1994

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

E-pub date: 28 Feb 1994

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

E-pub date: 01 Dec 1993

Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing.

E-pub date: 30 Nov 1992

Trans splicing of nematode pre-messenger RNA in vitro.

E-pub date: 31 May 1990

Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system.

E-pub date: 01 Jan 1990

Accurate processing of human pre-rRNA in vitro.

E-pub date: 01 Oct 1989

Accurate and efficient RNA polymerase III transcription in a cell-free extract prepared from Ascaris suum embryos.

E-pub date: 01 Jul 1989

Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi.

E-pub date: 30 Apr 1989

MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC.

E-pub date: 01 Sep 1985

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