Director of the CRI

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

E-pub date: 31 Jul 2019


Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019


piRNA-guided co-transcriptional silencing coopts nuclear export factors.

E-pub date: 31 May 2019


Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.

E-pub date: 30 Apr 2019


lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.

E-pub date: 31 Mar 2019


piRNA-Guided Genome Defense: From Biogenesis to Silencing.

E-pub date: 31 Oct 2018


Corrigendum to “GoldCLIP: Gel-omitted Ligation-dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

E-pub date: 01 Jun 2018


Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

E-pub date: 01 Jun 2018


COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

E-pub date: 02 Apr 2018


GoldCLIP: Gel-omitted Ligation-dependent CLIP.

E-pub date: 01 Apr 2018


Asparagine bioavailability governs metastasis in a model of breast cancer.

E-pub date: 15 Feb 2018


Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

E-pub date: 01 Feb 2018


lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

E-pub date: 06 Sep 2017


A Model for Epigenetic Inhibition via Transvection in the Mouse.

E-pub date: 01 Sep 2017


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 31 Aug 2017


lncRNAs in development and disease: from functions to mechanisms.

E-pub date: 31 Jul 2017


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

E-pub date: 20 Jul 2017


BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

E-pub date: 11 Jul 2017


The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

E-pub date: 22 Mar 2017


TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

E-pub date: 16 Jan 2017


Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

E-pub date: 18 Oct 2016


Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

E-pub date: 15 Jul 2016


One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

E-pub date: 01 Apr 2016


A Happy 3′ Ending to the piRNA Maturation Story.

E-pub date: 25 Feb 2016


Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

E-pub date: 04 Feb 2016


Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

E-pub date: 04 Jan 2016


The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

E-pub date: 01 Nov 2015


Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

E-pub date: 01 Nov 2015


Correction for Dequéant et al., Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 31 Oct 2015


Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

E-pub date: 20 Oct 2015


Panoramix enforces piRNA-dependent cotranscriptional silencing.

E-pub date: 16 Oct 2015


Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

E-pub date: 06 Oct 2015


Biochemical isolation of Argonaute protein complexes by Ago-APP.

E-pub date: 22 Sep 2015


RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

E-pub date: 01 Jul 2015


ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

E-pub date: 31 May 2015


An epigenetic memory of pregnancy in the mouse mammary gland.

E-pub date: 19 May 2015


piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

E-pub date: 15 May 2015


A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

E-pub date: 16 Apr 2015


Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

E-pub date: 23 Mar 2015


Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

E-pub date: 01 Feb 2015


A computational algorithm to predict shRNA potency.

E-pub date: 18 Dec 2014


MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

E-pub date: 15 Nov 2014


Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

E-pub date: 03 Nov 2014


A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

E-pub date: 31 Oct 2014


Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

E-pub date: 04 Sep 2014


Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

E-pub date: 17 Jul 2014


Two waves of de novo methylation during mouse germ cell development.

E-pub date: 15 Jul 2014


Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

E-pub date: 01 May 2014


Inducing RNAi in Drosophila cells by soaking with dsRNA.

E-pub date: 01 May 2014


A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

E-pub date: 01 Apr 2014


An atlas of chromatoid body components.

E-pub date: 01 Apr 2014


De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

E-pub date: 31 Oct 2013


Patient-derived tumor xenografts: transforming clinical samples into mouse models.

E-pub date: 01 Sep 2013


Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

E-pub date: 01 Sep 2013


A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

E-pub date: 31 Aug 2013


Minotaur is critical for primary piRNA biogenesis.

E-pub date: 31 Aug 2013


Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

E-pub date: 31 Aug 2013


Dicer-2 processes diverse viral RNA species.

E-pub date: 31 Aug 2013


Infection of mammalian cells with retroviral shRNAs.

E-pub date: 31 Jul 2013


Packaging shRNA retroviruses.

E-pub date: 31 Jul 2013


Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.

E-pub date: 15 Jul 2013


Creating an miR30-based shRNA vector.

E-pub date: 01 Jul 2013


The making of a slicer: activation of human Argonaute-1.

E-pub date: 27 Jun 2013


A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.

E-pub date: 06 Jun 2013


A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

E-pub date: 06 Jun 2013


DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

E-pub date: 28 May 2013


Dnmt2-dependent methylomes lack defined DNA methylation patterns.

E-pub date: 21 May 2013


Inducing RNAi in Drosophila cells by transfection with dsRNA.

E-pub date: 01 May 2013


Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

E-pub date: 30 Apr 2013


Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

E-pub date: 05 Apr 2013


Dogma derailed: the many influences of RNA on the genome.

E-pub date: 07 Mar 2013


Multiple roles for Piwi in silencing Drosophila transposons.

E-pub date: 15 Feb 2013


The piRNA pathway in flies: highlights and future directions.

E-pub date: 01 Feb 2013


Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

E-pub date: 01 Dec 2012


Site identification in high-throughput RNA-protein interaction data.

E-pub date: 01 Dec 2012


The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

E-pub date: 08 Nov 2012


Unique small RNA signatures uncovered in the tammar wallaby genome.

E-pub date: 17 Oct 2012


Preparation of small RNA libraries for high-throughput sequencing.

E-pub date: 01 Oct 2012


An integrated encyclopedia of DNA elements in the human genome.

E-pub date: 06 Sep 2012


Landscape of transcription in human cells.

E-pub date: 06 Sep 2012


RNAi in cultured mammalian cells using synthetic siRNAs.

E-pub date: 01 Sep 2012


shutdown is a component of the Drosophila piRNA biogenesis machinery.

E-pub date: 31 Aug 2012


Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

E-pub date: 31 Aug 2012


MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

E-pub date: 31 Aug 2012


Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

E-pub date: 31 Aug 2012


The structure of human argonaute-2 in complex with miR-20a.

E-pub date: 06 Jul 2012


Genomic landscape of human allele-specific DNA methylation.

E-pub date: 08 May 2012


Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

E-pub date: 01 Apr 2012


Production of transgenic calves expressing an shRNA targeting myostatin.

E-pub date: 31 Mar 2012


An alternative mode of microRNA target recognition.

E-pub date: 12 Feb 2012


A pipeline for the generation of shRNA transgenic mice.

E-pub date: 02 Feb 2012


Production of artificial piRNAs in flies and mice.

E-pub date: 31 Jan 2012


Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

E-pub date: 17 Jan 2012


Cell-type-based analysis of microRNA profiles in the mouse brain.

E-pub date: 12 Jan 2012


Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).

E-pub date: 01 Dec 2011


Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

E-pub date: 01 Nov 2011


miR-34 miRNAs provide a barrier for somatic cell reprogramming.

E-pub date: 23 Oct 2011


Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

E-pub date: 07 Oct 2011


Ancestral roles of small RNAs: an Ago-centric perspective.

E-pub date: 01 Oct 2011


Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.

E-pub date: 16 Sep 2011


Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

E-pub date: 01 Sep 2011


Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

E-pub date: 01 Sep 2011


Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

E-pub date: 01 Sep 2011


piRNA production requires heterochromatin formation in Drosophila.

E-pub date: 23 Aug 2011


Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

E-pub date: 28 Jun 2011


A genome-scale shRNA resource for transgenic RNAi in Drosophila.

E-pub date: 31 May 2011


Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

E-pub date: 31 May 2011


Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

E-pub date: 19 May 2011


A rapid and scalable system for studying gene function in mice using conditional RNA interference.

E-pub date: 01 Apr 2011


A user’s guide to the encyclopedia of DNA elements (ENCODE).

E-pub date: 01 Apr 2011


Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

E-pub date: 25 Mar 2011


FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

E-pub date: 24 Mar 2011


Silencing of microRNA families by seed-targeting tiny LNAs.

E-pub date: 20 Mar 2011


Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

E-pub date: 18 Mar 2011


Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

E-pub date: 01 Feb 2011


Small RNA sorting: matchmaking for Argonautes.

E-pub date: 31 Jan 2011


Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

E-pub date: 31 Jan 2011


Identification of functional elements and regulatory circuits by Drosophila modENCODE.

E-pub date: 30 Nov 2010


Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.

E-pub date: 15 Nov 2010


Canonical and alternate functions of the microRNA biogenesis machinery.

E-pub date: 01 Sep 2010


Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.

E-pub date: 31 Aug 2010


Targeted enrichment of specific regions in the human genome by array hybridization.

E-pub date: 31 Jul 2010


Enrichment of poly(A)+ mRNA using immobilized oligo(dT).

E-pub date: 30 Jun 2010


Guidelines for the use of RNA purification kits.

E-pub date: 30 Jun 2010


A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.

E-pub date: 25 Jun 2010


Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

E-pub date: 25 Jun 2010


A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

E-pub date: 03 Jun 2010


Nondenaturing agarose gel electrophoresis of RNA.

E-pub date: 01 Jun 2010


Removal of ribosomal subunits (and rRNA) from cytoplasmic extracts before solubilization with SDS and deproteinization.

E-pub date: 01 Jun 2010


Ethanol precipitation of RNA and the use of carriers.

E-pub date: 01 Jun 2010


Determining the yield and quality of purified RNA.

E-pub date: 01 Jun 2010


Preparation of cytoplasmic and nuclear RNA from tissue culture cells.

E-pub date: 01 Jun 2010


Purification of RNA by SDS solubilization and phenol extraction.

E-pub date: 01 Jun 2010


Removal of DNA from RNA.

E-pub date: 01 Jun 2010


Purification of RNA using TRIzol (TRI reagent).

E-pub date: 01 Jun 2010


Polyacrylamide gel electrophoresis of RNA.

E-pub date: 01 Jun 2010


Targeted investigation of the Neandertal genome by array-based sequence capture.

E-pub date: 07 May 2010


Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

E-pub date: 02 Apr 2010


Ancient animal microRNAs and the evolution of tissue identity.

E-pub date: 25 Feb 2010


Compressed Genotyping.

E-pub date: 01 Feb 2010


Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

E-pub date: 31 Jan 2010


Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation.

E-pub date: 31 Jan 2010


The CRISPR system: small RNA-guided defense in bacteria and archaea.

E-pub date: 15 Jan 2010


The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

E-pub date: 01 Jan 2010


Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

E-pub date: 31 Dec 2009


miR-19 is a key oncogenic component of mir-17-92.

E-pub date: 15 Dec 2009


Arginine methylation as a molecular signature of the Piwi small RNA pathway.

E-pub date: 15 Dec 2009


Hierarchical rules for Argonaute loading in Drosophila.

E-pub date: 13 Nov 2009


Updates to the RMAP short-read mapping software.

E-pub date: 01 Nov 2009


Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

E-pub date: 31 Oct 2009


Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

E-pub date: 06 Oct 2009


Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

E-pub date: 24 Sep 2009


The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

E-pub date: 15 Sep 2009


Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila.

E-pub date: 01 Sep 2009


High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

E-pub date: 01 Sep 2009


Molecular evolution of piRNA and transposon control pathways in Drosophila.

E-pub date: 31 Aug 2009


Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

E-pub date: 31 Aug 2009


Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.

E-pub date: 15 Aug 2009


Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

E-pub date: 01 Aug 2009


DNA Sudoku–harnessing high-throughput sequencing for multiplexed specimen analysis.

E-pub date: 31 Jul 2009


Cyfip1 is a putative invasion suppressor in epithelial cancers.

E-pub date: 12 Jun 2009


Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

E-pub date: 01 May 2009


Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

E-pub date: 20 Mar 2009


The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.

E-pub date: 24 Feb 2009


Small RNAs as guardians of the genome.

E-pub date: 20 Feb 2009


Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs.

E-pub date: 19 Feb 2009


Design of 240,000 orthogonal 25mer DNA barcode probes.

E-pub date: 17 Feb 2009


miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.

E-pub date: 31 Dec 2008


An epigenetic role for maternally inherited piRNAs in transposon silencing.

E-pub date: 28 Nov 2008


An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

E-pub date: 28 Nov 2008


Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

E-pub date: 21 Nov 2008


A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

E-pub date: 26 Sep 2008


A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 01 Sep 2008


Small RNA silencing pathways in germ and stem cells.

E-pub date: 31 Aug 2008


Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.

E-pub date: 31 Aug 2008


Topoisomerase levels determine chemotherapy response in vitro and in vivo.

E-pub date: 01 Jul 2008


An endogenous small interfering RNA pathway in Drosophila.

E-pub date: 05 Jun 2008


Conservation of small RNA pathways in platypus.

E-pub date: 01 Jun 2008


Astrin regulates Aurora-A localization.

E-pub date: 30 May 2008


Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

E-pub date: 22 May 2008


Genome analysis of the platypus reveals unique signatures of evolution.

E-pub date: 08 May 2008


Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

E-pub date: 22 Apr 2008


Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5′ terminal nucleotide.

E-pub date: 04 Apr 2008


A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.

E-pub date: 31 Mar 2008


Conserved themes in small-RNA-mediated transposon control.

E-pub date: 31 Mar 2008


Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

E-pub date: 12 Feb 2008


Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

E-pub date: 01 Feb 2008


Cancer proliferation gene discovery through functional genomics.

E-pub date: 01 Feb 2008


Profiling essential genes in human mammary cells by multiplex RNAi screening.

E-pub date: 01 Feb 2008


Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

E-pub date: 01 Jan 2008


Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.

E-pub date: 31 Dec 2007


Genome-wide in situ exon capture for selective resequencing.

E-pub date: 31 Dec 2007


A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

E-pub date: 15 Dec 2007


A biochemical approach to identifying microRNA targets.

E-pub date: 04 Dec 2007


The guardian’s little helper: microRNAs in the p53 tumor suppressor network.

E-pub date: 01 Dec 2007


Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.

E-pub date: 08 Nov 2007


The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.

E-pub date: 02 Nov 2007


microRNAs join the p53 network–another piece in the tumour-suppression puzzle.

E-pub date: 01 Nov 2007


A MicroRNA feedback circuit in midbrain dopamine neurons.

E-pub date: 31 Aug 2007


[The role of piRNAs in mouse spermatogenesis.].

E-pub date: 31 Aug 2007


Tissue-specific and reversible RNA interference in transgenic mice.

E-pub date: 31 Jul 2007


A microRNA component of the p53 tumour suppressor network.

E-pub date: 28 Jun 2007


A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

E-pub date: 31 May 2007


A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

E-pub date: 15 May 2007


Developmentally regulated piRNA clusters implicate MILI in transposon control.

E-pub date: 04 May 2007


Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

E-pub date: 19 Apr 2007


A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

E-pub date: 06 Apr 2007


MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

E-pub date: 01 Apr 2007


Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

E-pub date: 23 Mar 2007


Critical roles for Dicer in the female germline.

E-pub date: 15 Mar 2007


Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

E-pub date: 31 May 2003


A survey of canine expressed sequence tags and a display of their annotations through a flexible web-based interface.

E-pub date: 01 Jan 2003


The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

E-pub date: 30 Nov 2002


Oncogenic ras and p53 cooperate to induce cellular senescence.

E-pub date: 01 May 2002


Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

E-pub date: 31 May 2000


A proinflammatory cytokine inhibits p53 tumor suppressor activity.

E-pub date: 31 Oct 1999


Twist is a potential oncogene that inhibits apoptosis.

E-pub date: 31 Aug 1999


MaRX: an approach to genetics in mammalian cells.

E-pub date: 31 Jan 1999


p53-independent role of MDM2 in TGF-beta1 resistance.

E-pub date: 30 Nov 1998


Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.

E-pub date: 31 Oct 1998


Oncogene-dependent apoptosis is mediated by caspase-9.

E-pub date: 31 Oct 1998


The INK4 family of CDK inhibitors.

E-pub date: 01 Aug 1998


Myc activates telomerase.

E-pub date: 31 May 1998


Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

E-pub date: 31 Oct 1996


Shared role of the pRB-related p130 and p107 proteins in limb development.

E-pub date: 30 Jun 1996


Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 –> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

E-pub date: 31 May 1996


Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage.

E-pub date: 31 Jan 1996


Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.

E-pub date: 01 Oct 1995


Deletion of the p16 and p15 genes in human bladder tumors.

E-pub date: 30 Sep 1995


p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

E-pub date: 31 Mar 1995


Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

E-pub date: 31 Jan 1995


p21 is a component of active cell cycle kinases.

E-pub date: 01 Aug 1994


p21-containing cyclin kinases exist in both active and inactive states.

E-pub date: 31 Jul 1994


Construction of an improved host strain for two hybrid screening.

E-pub date: 31 Mar 1994


KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

E-pub date: 28 Feb 1994


Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

E-pub date: 01 Dec 1993


Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing.

E-pub date: 30 Nov 1992


Trans splicing of nematode pre-messenger RNA in vitro.

E-pub date: 31 May 1990


Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system.

E-pub date: 01 Jan 1990


Accurate processing of human pre-rRNA in vitro.

E-pub date: 01 Oct 1989


Accurate and efficient RNA polymerase III transcription in a cell-free extract prepared from Ascaris suum embryos.

E-pub date: 01 Jul 1989


Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi.

E-pub date: 30 Apr 1989


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
12/09/2018
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Cold Spring Harbor Laboratory Yes No No Yes No No No Yes
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