Group Leader

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.

E-pub date: 08 Nov 2016

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells.

E-pub date: 19 Aug 2014

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

E-pub date: 10 Dec 2013

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013

Transcriptional regulation of effector and memory CD8+ T cell fates.

E-pub date: 01 Jun 2013

Control of HIV infection: escape from the shadow of Blimp-1.

E-pub date: 01 Feb 2013

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.

E-pub date: 14 Aug 2012

Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

E-pub date: 01 Mar 2012

siRNA high-throughput kinase library screen identifies protein kinase, DNA-activated catalytic polypeptide to play a role in MyD88-induced IFNA2 activation and IL-8 secretion.

E-pub date: 31 Jan 2012

T-bet-mediated differentiation of the activated CD8+ T cell.

E-pub date: 31 Jan 2011

Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.

E-pub date: 15 Dec 2010

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

E-pub date: 05 Nov 2010

The precursors of memory: models and controversies.

E-pub date: 01 Sep 2009

Secondary replicative function of CD8+ T cells that had developed an effector phenotype.

E-pub date: 23 Jan 2009

Inflammation and cardiovascular disease: role of the interleukin-1 receptor antagonist.

E-pub date: 20 May 2008

The expansion and maintenance of antigen-selected CD8(+) T cell clones.

E-pub date: 31 Aug 2007

Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.

E-pub date: 14 Aug 2007

Bcl-6 uncouples B lymphocyte proliferation from differentiation.

E-pub date: 01 Aug 2002

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

E-pub date: 30 Nov 2000

Receptor modulators of B-cell receptor signalling–CD19/CD22.

E-pub date: 01 Aug 2000

Innate immunity and the biological relevance of the acquired immune response.

E-pub date: 01 May 1999

Transplanted hepatocytes infected with a complement receptor type 1 (CR1)-containing recombinant adenovirus are resistant to hyperacute rejection.

E-pub date: 01 Feb 1999

Non-structural determinants of immunogenicity and the B cell co-receptors, CD19, CD21, and CD22.

E-pub date: 01 Aug 1998

Inhibition of the B cell by CD22: a requirement for Lyn.

E-pub date: 28 Feb 1998

Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.

E-pub date: 31 Oct 1997

Construction, function and in vivo expression of a complement receptor type 1 containing recombinant adenovirus for use in xenotransplantation.

E-pub date: 01 Feb 1997

The instructive role of innate immunity in the acquired immune response.

E-pub date: 31 Mar 1996

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

E-pub date: 31 Dec 1995

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity.

E-pub date: 31 Dec 1995

CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.

E-pub date: 01 Dec 1995

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.

E-pub date: 30 Jun 1995

Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.

E-pub date: 30 Sep 1993

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

E-pub date: 30 Jun 1993

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

E-pub date: 30 Apr 1993

Human anti-endotoxin antibody HA-1A mediates complement-dependent binding of Escherichia coli J5 lipopolysaccharide to complement receptor type 1 of human erythrocytes and neutrophils.

E-pub date: 01 Apr 1993

CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

E-pub date: 31 Mar 1992

Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2.

E-pub date: 30 Nov 1991

Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab’)2 chimeric complement inhibitor.

E-pub date: 30 Nov 1991

Anti-inflammatory and immunosuppressive effects of recombinant soluble complement receptors.

E-pub date: 01 Oct 1991

Suppression of the immune response by a soluble complement receptor of B lymphocytes.

E-pub date: 30 Sep 1991

Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

E-pub date: 30 Apr 1991

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

E-pub date: 31 Mar 1991

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

E-pub date: 31 Dec 1990

Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor; CD21).

E-pub date: 01 Aug 1990

Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.

E-pub date: 30 Jun 1990

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.

E-pub date: 30 Nov 1989

Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

E-pub date: 28 Feb 1989

Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.

E-pub date: 01 Dec 1988

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

E-pub date: 31 Oct 1988

Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

E-pub date: 31 Mar 1988

Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

E-pub date: 29 Feb 1988

Hereditary angioedema: a decade of management with stanozolol.

E-pub date: 01 Dec 1987

Human receptor for C3b/C4b: complement receptor type I.

E-pub date: 01 Aug 1987

Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

E-pub date: 31 Mar 1987

Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype.

E-pub date: 31 Oct 1986

Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

E-pub date: 31 Aug 1986

Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacities.

E-pub date: 31 Jul 1986

Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes.

E-pub date: 30 Jun 1986

Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus.

E-pub date: 01 Jun 1986

Tissue-specific phosphorylation of complement receptors CR1 and CR2.

E-pub date: 31 Dec 1985

Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

E-pub date: 01 Nov 1985

Rapid purification of the human C3b/C4b receptor (CR1) by monoclonal antibody affinity chromatography.

E-pub date: 30 Sep 1985

Human complement receptors for C3b (CR1) and C3d (CR2).

E-pub date: 01 Jul 1985

Acquired deficiency of the inhibitor of the first component of complement: report of five additional cases with commentary on the syndrome.

E-pub date: 01 Jun 1985

Altered expression of complement receptors as a pathogenetic factor in systemic lupus erythematosus.

E-pub date: 01 Dec 1984

Biocompatibility of dialysis membranes: effects of chronic complement activation.

E-pub date: 31 Aug 1984

Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

E-pub date: 01 Jul 1984

Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

E-pub date: 01 Feb 1984

Continuing medical education. This continuing medical education self-assessment program is sponsored by the American Academy of Allergy and Immunology and supported by a grant-in-aid from Fisons Corporation.

E-pub date: 01 Jun 1983

Lipid monolayer-coated solid surfaces do not perturb the lateral motion and distribution of C3b receptors on neutrophils.

E-pub date: 01 Jul 1982

Immunohistochemical study of the human glomerular C3b receptor in normal kidney and in seventy-five cases of renal diseases: loss of C3b receptor antigen in focal hyalinosis and in proliferative nephritis of systemic lupus erythematosus.

E-pub date: 01 Apr 1982

Clinical and biochemical effects of stanozolol therapy for hereditary angioedema.

E-pub date: 01 Sep 1981

Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.

E-pub date: 31 May 1981

Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes.

E-pub date: 01 Nov 1980

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.

E-pub date: 30 Jun 1980

Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.

E-pub date: 01 Nov 1979

Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.

E-pub date: 31 Oct 1979

Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema.

E-pub date: 01 Oct 1979

Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway.

E-pub date: 01 Dec 1978

Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.

E-pub date: 31 Aug 1978

Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway.

E-pub date: 01 Apr 1978

Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.

E-pub date: 31 Jan 1978

Tranexamic acid: preoperative prophylactic therapy for patients with hereditary angioneurotic edema.

E-pub date: 01 Jul 1977

Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins.

E-pub date: 30 Jun 1977

Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.

E-pub date: 01 Apr 1977

Methyltestosterone therapy in hereditary angioedema.

E-pub date: 01 Mar 1977

Control of the amplification convertase of complement by the plasma protein beta1H.

E-pub date: 01 Sep 1976

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

E-pub date: 30 Sep 1975

Properdin: initiation of alternative complement pathway.

E-pub date: 31 Aug 1975

Depressed synovial fluid levels of properdin and properdin factor B in patients with rheumatoid arthritis.

E-pub date: 01 Jul 1975

Inhibition of complement-derived enzymes.

E-pub date: 31 May 1975

Properdin factor D. II. Activation to D by properdin.

E-pub date: 31 Jul 1974

Properdin factor D: characterization of its active site and isolation of the precursor form.

E-pub date: 31 Jan 1974

Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complement.

E-pub date: 30 Nov 1973

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