Group Leader

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.

E-pub date: 08 Nov 2016


Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells.

E-pub date: 19 Aug 2014


Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

E-pub date: 10 Dec 2013


Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013


Transcriptional regulation of effector and memory CD8+ T cell fates.

E-pub date: 01 Jun 2013


Control of HIV infection: escape from the shadow of Blimp-1.

E-pub date: 01 Feb 2013


Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.

E-pub date: 14 Aug 2012


Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

E-pub date: 01 Mar 2012


siRNA high-throughput kinase library screen identifies protein kinase, DNA-activated catalytic polypeptide to play a role in MyD88-induced IFNA2 activation and IL-8 secretion.

E-pub date: 31 Jan 2012


T-bet-mediated differentiation of the activated CD8+ T cell.

E-pub date: 31 Jan 2011


Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.

E-pub date: 15 Dec 2010


Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

E-pub date: 05 Nov 2010


The precursors of memory: models and controversies.

E-pub date: 01 Sep 2009


Secondary replicative function of CD8+ T cells that had developed an effector phenotype.

E-pub date: 23 Jan 2009


Inflammation and cardiovascular disease: role of the interleukin-1 receptor antagonist.

E-pub date: 20 May 2008


The expansion and maintenance of antigen-selected CD8(+) T cell clones.

E-pub date: 31 Aug 2007


Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.

E-pub date: 14 Aug 2007


Bcl-6 uncouples B lymphocyte proliferation from differentiation.

E-pub date: 01 Aug 2002


Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

E-pub date: 30 Nov 2000


Innate immunity and the biological relevance of the acquired immune response.

E-pub date: 01 May 1999


Transplanted hepatocytes infected with a complement receptor type 1 (CR1)-containing recombinant adenovirus are resistant to hyperacute rejection.

E-pub date: 01 Feb 1999


Non-structural determinants of immunogenicity and the B cell co-receptors, CD19, CD21, and CD22.

E-pub date: 01 Aug 1998


Inhibition of the B cell by CD22: a requirement for Lyn.

E-pub date: 28 Feb 1998


Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.

E-pub date: 31 Oct 1997


The instructive role of innate immunity in the acquired immune response.

E-pub date: 31 Mar 1996


A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

E-pub date: 31 Dec 1995


C3d of complement as a molecular adjuvant: bridging innate and acquired immunity.

E-pub date: 31 Dec 1995


CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.

E-pub date: 01 Dec 1995


A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.

E-pub date: 30 Jun 1995


Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.

E-pub date: 30 Sep 1993


A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

E-pub date: 30 Jun 1993


CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

E-pub date: 30 Apr 1993


Human anti-endotoxin antibody HA-1A mediates complement-dependent binding of Escherichia coli J5 lipopolysaccharide to complement receptor type 1 of human erythrocytes and neutrophils.

E-pub date: 01 Apr 1993


CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

E-pub date: 31 Mar 1992


Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2.

E-pub date: 30 Nov 1991


Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab’)2 chimeric complement inhibitor.

E-pub date: 30 Nov 1991


Anti-inflammatory and immunosuppressive effects of recombinant soluble complement receptors.

E-pub date: 01 Oct 1991


Suppression of the immune response by a soluble complement receptor of B lymphocytes.

E-pub date: 30 Sep 1991


Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

E-pub date: 30 Apr 1991


Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

E-pub date: 31 Mar 1991


Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

E-pub date: 31 Dec 1990


Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.

E-pub date: 30 Jun 1990


Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.

E-pub date: 30 Nov 1989


Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

E-pub date: 28 Feb 1989


Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.

E-pub date: 01 Dec 1988


Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

E-pub date: 31 Oct 1988


Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

E-pub date: 31 Mar 1988


Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

E-pub date: 29 Feb 1988


Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

E-pub date: 31 Mar 1987


Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype.

E-pub date: 31 Oct 1986


Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

E-pub date: 31 Aug 1986


Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes.

E-pub date: 30 Jun 1986


Tissue-specific phosphorylation of complement receptors CR1 and CR2.

E-pub date: 31 Dec 1985


Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

E-pub date: 01 Nov 1985


Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

E-pub date: 01 Jul 1984


Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

E-pub date: 01 Feb 1984


Lipid monolayer-coated solid surfaces do not perturb the lateral motion and distribution of C3b receptors on neutrophils.

E-pub date: 01 Jul 1982


Immunohistochemical study of the human glomerular C3b receptor in normal kidney and in seventy-five cases of renal diseases: loss of C3b receptor antigen in focal hyalinosis and in proliferative nephritis of systemic lupus erythematosus.

E-pub date: 01 Apr 1982


Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.

E-pub date: 31 May 1981


Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes.

E-pub date: 01 Nov 1980


Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.

E-pub date: 30 Jun 1980


Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.

E-pub date: 01 Nov 1979


Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.

E-pub date: 31 Oct 1979


Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway.

E-pub date: 01 Dec 1978


Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.

E-pub date: 31 Aug 1978


Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway.

E-pub date: 01 Apr 1978


Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.

E-pub date: 31 Jan 1978


Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins.

E-pub date: 30 Jun 1977


Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.

E-pub date: 01 Apr 1977


Methyltestosterone therapy in hereditary angioedema.

E-pub date: 01 Mar 1977


Control of the amplification convertase of complement by the plasma protein beta1H.

E-pub date: 01 Sep 1976


Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

E-pub date: 30 Sep 1975


Properdin: initiation of alternative complement pathway.

E-pub date: 31 Aug 1975


Inhibition of complement-derived enzymes.

E-pub date: 31 May 1975


Properdin factor D. II. Activation to D by properdin.

E-pub date: 31 Jul 1974


Properdin factor D: characterization of its active site and isolation of the precursor form.

E-pub date: 31 Jan 1974


Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complement.

E-pub date: 30 Nov 1973


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