Group Leader

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.

E-pub date: 08 Nov 2016


Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells.

E-pub date: 19 Aug 2014


Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

E-pub date: 10 Dec 2013


Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

E-pub date: 03 Jun 2013


Transcriptional regulation of effector and memory CD8+ T cell fates.

E-pub date: 01 Jun 2013


Control of HIV infection: escape from the shadow of Blimp-1.

E-pub date: 01 Feb 2013


Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.

E-pub date: 14 Aug 2012


Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

E-pub date: 01 Mar 2012


siRNA high-throughput kinase library screen identifies protein kinase, DNA-activated catalytic polypeptide to play a role in MyD88-induced IFNA2 activation and IL-8 secretion.

E-pub date: 31 Jan 2012


T-bet-mediated differentiation of the activated CD8+ T cell.

E-pub date: 31 Jan 2011


Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.

E-pub date: 15 Dec 2010


Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

E-pub date: 05 Nov 2010


The precursors of memory: models and controversies.

E-pub date: 01 Sep 2009


Secondary replicative function of CD8+ T cells that had developed an effector phenotype.

E-pub date: 23 Jan 2009


Inflammation and cardiovascular disease: role of the interleukin-1 receptor antagonist.

E-pub date: 20 May 2008


The expansion and maintenance of antigen-selected CD8(+) T cell clones.

E-pub date: 31 Aug 2007


Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.

E-pub date: 14 Aug 2007


Bcl-6 uncouples B lymphocyte proliferation from differentiation.

E-pub date: 01 Aug 2002


IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19.

E-pub date: 01 Jul 2001


Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

E-pub date: 30 Nov 2000


Receptor modulators of B-cell receptor signalling–CD19/CD22.

E-pub date: 01 Aug 2000


Innate immunity and the biological relevance of the acquired immune response.

E-pub date: 01 May 1999


Transplanted hepatocytes infected with a complement receptor type 1 (CR1)-containing recombinant adenovirus are resistant to hyperacute rejection.

E-pub date: 01 Feb 1999


Non-structural determinants of immunogenicity and the B cell co-receptors, CD19, CD21, and CD22.

E-pub date: 01 Aug 1998


CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

E-pub date: 01 May 1998


Inhibition of the B cell by CD22: a requirement for Lyn.

E-pub date: 28 Feb 1998


Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.

E-pub date: 31 Oct 1997


Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin.

E-pub date: 01 Jul 1997


Co-receptors of B lymphocytes.

E-pub date: 01 Jun 1997


Construction, function and in vivo expression of a complement receptor type 1 containing recombinant adenovirus for use in xenotransplantation.

E-pub date: 01 Feb 1997


Innate pathways that control acquired immunity.

E-pub date: 01 Feb 1997


Activation of B lymphocytes: integrating signals from CD19, CD22 and Fc gamma RIIb1.

E-pub date: 01 Jun 1996


The instructive role of innate immunity in the acquired immune response.

E-pub date: 31 Mar 1996


Complement: instructing the acquired immune system through the CD21/CD19 complex.

E-pub date: 01 Feb 1996


A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

E-pub date: 31 Dec 1995


C3d of complement as a molecular adjuvant: bridging innate and acquired immunity.

E-pub date: 31 Dec 1995


CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.

E-pub date: 01 Dec 1995


A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.

E-pub date: 30 Jun 1995


Therapeutic uses of recombinant complement protein inhibitors.

E-pub date: 01 Aug 1994


Innate immunity: 50 ways to kill a microbe.

E-pub date: 01 Feb 1994


Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.

E-pub date: 30 Sep 1993


A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

E-pub date: 30 Jun 1993


The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes.

E-pub date: 01 Jun 1993


CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

E-pub date: 30 Apr 1993


Human anti-endotoxin antibody HA-1A mediates complement-dependent binding of Escherichia coli J5 lipopolysaccharide to complement receptor type 1 of human erythrocytes and neutrophils.

E-pub date: 01 Apr 1993


CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

E-pub date: 31 Mar 1992


Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2.

E-pub date: 30 Nov 1991


Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab’)2 chimeric complement inhibitor.

E-pub date: 30 Nov 1991


Anti-inflammatory and immunosuppressive effects of recombinant soluble complement receptors.

E-pub date: 01 Oct 1991


Suppression of the immune response by a soluble complement receptor of B lymphocytes.

E-pub date: 30 Sep 1991


Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

E-pub date: 30 Apr 1991


Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

E-pub date: 31 Mar 1991


Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

E-pub date: 31 Dec 1990


Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor; CD21).

E-pub date: 01 Aug 1990


Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.

E-pub date: 30 Jun 1990


Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.

E-pub date: 30 Nov 1989


Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21).

E-pub date: 01 Aug 1989


Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

E-pub date: 28 Feb 1989


Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.

E-pub date: 01 Dec 1988


Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

E-pub date: 31 Oct 1988


Complement, C receptors, and immune complex disease.

E-pub date: 31 Jul 1988


Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

E-pub date: 31 Mar 1988


Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

E-pub date: 29 Feb 1988


Hereditary angioedema: a decade of management with stanozolol.

E-pub date: 01 Dec 1987


Human receptor for C3b/C4b: complement receptor type I.

E-pub date: 01 Aug 1987


CR1 and the cell membrane proteins that bind C3 and C4. A basic and clinical review.

E-pub date: 01 Aug 1987


Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

E-pub date: 31 Mar 1987


Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype.

E-pub date: 31 Oct 1986


Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

E-pub date: 31 Aug 1986


Decreased expression of C3b receptor (CR1) on erythrocytes of patients with systemic lupus erythematosus contrasts with its normal expression in other systemic diseases and does not correlate with the occurrence or severity of SLE nephritis.

E-pub date: 01 Aug 1986


Purification of the B lymphocyte receptor for the C3d fragment of complement and the Epstein-Barr virus by monoclonal antibody affinity chromatography, and assessment of its functional capacities.

E-pub date: 31 Jul 1986


Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes.

E-pub date: 30 Jun 1986


Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus.

E-pub date: 01 Jun 1986


The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation.

E-pub date: 01 Jan 1986


Tissue-specific phosphorylation of complement receptors CR1 and CR2.

E-pub date: 31 Dec 1985


Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

E-pub date: 01 Nov 1985


Rapid purification of the human C3b/C4b receptor (CR1) by monoclonal antibody affinity chromatography.

E-pub date: 30 Sep 1985


Human complement receptors for C3b (CR1) and C3d (CR2).

E-pub date: 01 Jul 1985


Acquired deficiency of the inhibitor of the first component of complement: report of five additional cases with commentary on the syndrome.

E-pub date: 01 Jun 1985


Altered expression of complement receptors as a pathogenetic factor in systemic lupus erythematosus.

E-pub date: 01 Dec 1984


Biocompatibility of dialysis membranes: effects of chronic complement activation.

E-pub date: 31 Aug 1984


Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

E-pub date: 01 Jul 1984


Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

E-pub date: 01 Feb 1984


The human C3b receptor.

E-pub date: 01 Aug 1983


The role of antibody in the activation of the alternative complement pathway.

E-pub date: 01 Aug 1983


Continuing medical education. This continuing medical education self-assessment program is sponsored by the American Academy of Allergy and Immunology and supported by a grant-in-aid from Fisons Corporation.

E-pub date: 01 Jun 1983


Lipid monolayer-coated solid surfaces do not perturb the lateral motion and distribution of C3b receptors on neutrophils.

E-pub date: 01 Jul 1982


Immunohistochemical study of the human glomerular C3b receptor in normal kidney and in seventy-five cases of renal diseases: loss of C3b receptor antigen in focal hyalinosis and in proliferative nephritis of systemic lupus erythematosus.

E-pub date: 01 Apr 1982


Clinical and biochemical effects of stanozolol therapy for hereditary angioedema.

E-pub date: 01 Sep 1981


Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.

E-pub date: 31 May 1981


Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes.

E-pub date: 01 Nov 1980


Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.

E-pub date: 30 Jun 1980


Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.

E-pub date: 01 Nov 1979


Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b.

E-pub date: 31 Oct 1979


Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema.

E-pub date: 01 Oct 1979


Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway.

E-pub date: 01 Dec 1978


Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.

E-pub date: 31 Aug 1978


Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway.

E-pub date: 01 Apr 1978


Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.

E-pub date: 31 Jan 1978


Tranexamic acid: preoperative prophylactic therapy for patients with hereditary angioneurotic edema.

E-pub date: 01 Jul 1977


Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins.

E-pub date: 30 Jun 1977


Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.

E-pub date: 01 Apr 1977


Methyltestosterone therapy in hereditary angioedema.

E-pub date: 01 Mar 1977


Control of the amplification convertase of complement by the plasma protein beta1H.

E-pub date: 01 Sep 1976


The natural modulation of the amplification phase of complement activation.

E-pub date: 01 Aug 1976


Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

E-pub date: 30 Sep 1975


Properdin: initiation of alternative complement pathway.

E-pub date: 31 Aug 1975


Depressed synovial fluid levels of properdin and properdin factor B in patients with rheumatoid arthritis.

E-pub date: 01 Jul 1975


Inhibition of complement-derived enzymes.

E-pub date: 31 May 1975


Properdin factor D. II. Activation to D by properdin.

E-pub date: 31 Jul 1974


Properdin factor D: characterization of its active site and isolation of the precursor form.

E-pub date: 31 Jan 1974


Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complement.

E-pub date: 30 Nov 1973


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