Professor of Cancer Medicine

Research Group Home Page: 
Caldas Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.

E-pub date: 30 Nov 2018


A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

E-pub date: 30 Sep 2018


Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

E-pub date: 31 Aug 2018


Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

E-pub date: 31 Aug 2018


Effects of collection and processing procedures on plasma circulating cell-free DNA from cancer patients.

E-pub date: 31 Jul 2018


SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis.

E-pub date: 31 Jul 2018


Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study.

E-pub date: 31 Jul 2018


MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

E-pub date: 31 Jul 2018


High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.

E-pub date: 01 Jul 2018


Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.

E-pub date: 01 Jun 2018


Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.

E-pub date: 01 Jun 2018


Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion.

E-pub date: 31 May 2018


Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.

E-pub date: 31 May 2018


Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

E-pub date: 31 May 2018


αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.

E-pub date: 17 May 2018


RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.

E-pub date: 01 May 2018


Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants.

E-pub date: 01 Apr 2018


Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus.

E-pub date: 15 Mar 2018


Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.

E-pub date: 07 Mar 2018


Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status.

E-pub date: 01 Feb 2018


SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.

E-pub date: 30 Jan 2018


Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.

E-pub date: 05 Jan 2018


Body mass index and breast cancer survival: a Mendelian randomization analysis.

E-pub date: 01 Dec 2017


PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

E-pub date: 01 Nov 2017


Germline variation in inflammation-related pathways and risk of Barrett’s oesophagus and oesophageal adenocarcinoma.

E-pub date: 31 Oct 2017


High-risk individuals’ perceptions of reproductive genetic testing for CDH1 mutations.

E-pub date: 31 Oct 2017


Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters.

E-pub date: 31 Oct 2017


A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.

E-pub date: 31 Oct 2017


Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer.

E-pub date: 10 Oct 2017


Of mice and men: patient-derived xenografts in cancer medicine.

E-pub date: 01 Oct 2017


The Psychosocial Impact of Undergoing Prophylactic Total Gastrectomy (PTG) to Manage the Risk of Hereditary Diffuse Gastric Cancer (HDGC).

E-pub date: 31 Aug 2017


Predicting treatment resistance and relapse through circulating DNA.

E-pub date: 31 Aug 2017


The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

E-pub date: 25 Aug 2017


Lymphocyte density determined by computational pathology validated as a predictor of response to neoadjuvant chemotherapy in breast cancer: secondary analysis of the ARTemis trial.

E-pub date: 01 Aug 2017


Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial.

E-pub date: 01 Aug 2017


Ki67 expression in invasive breast cancer: the use of tissue microarrays compared with whole tissue sections.

E-pub date: 31 Jul 2017


Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.

E-pub date: 15 Jul 2017


Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.

E-pub date: 11 Jul 2017


Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity.

E-pub date: 07 Jul 2017


Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.

E-pub date: 01 Jun 2017


Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers.

E-pub date: 18 Apr 2017


Liquid biopsies come of age: towards implementation of circulating tumour DNA.

E-pub date: 01 Apr 2017


Interrogating open issues in cancer precision medicine with patient-derived xenografts.

E-pub date: 01 Apr 2017


Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

E-pub date: 30 Mar 2017


Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.

E-pub date: 29 Mar 2017


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

E-pub date: 17 Feb 2017


Weibull regression with Bayesian variable selection to identify prognostic tumour markers of breast cancer survival.

E-pub date: 01 Feb 2017


Further evidence to support bimodality of oestrogen receptor expression in breast cancer.

E-pub date: 01 Feb 2017


Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study.

E-pub date: 31 Dec 2016


p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

E-pub date: 22 Dec 2016


The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer.

E-pub date: 01 Dec 2016


An investigation of the factors effecting high-risk individuals’ decision-making about prophylactic total gastrectomy and surveillance for hereditary diffuse gastric cancer (HDGC).

E-pub date: 31 Oct 2016


Genome-wide association studies in oesophageal adenocarcinoma and Barrett’s oesophagus: a large-scale meta-analysis.

E-pub date: 31 Oct 2016


Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

E-pub date: 01 Oct 2016


Nucleosome mapping in plasma DNA predicts cancer gene expression.

E-pub date: 28 Sep 2016


Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.

E-pub date: 26 Sep 2016


A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

E-pub date: 22 Sep 2016


Subtype-specific micro-RNA expression signatures in breast cancer progression.

E-pub date: 01 Sep 2016


Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis.

E-pub date: 01 Sep 2016


It’s PRIMETIME. Postoperative Avoidance of Radiotherapy: Biomarker Selection of Women at Very Low Risk of Local Recurrence.

E-pub date: 01 Sep 2016


Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

E-pub date: 31 Aug 2016


The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.

E-pub date: 31 Aug 2016


Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer.

E-pub date: 31 Aug 2016


Modeling Breast Cancer Intertumor and Intratumor Heterogeneity Using Xenografts.

E-pub date: 31 Aug 2016


Stratification and therapeutic potential of PML in metastatic breast cancer.

E-pub date: 24 Aug 2016


Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated annealing, extension, selection, and ligation whole-genome (DASL WG) assay.

E-pub date: 20 Aug 2016


SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.

E-pub date: 31 Jul 2016


Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

E-pub date: 01 Jul 2016


Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

E-pub date: 02 Jun 2016


A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

E-pub date: 01 Jun 2016


Excellent translational research in oncology: A journey towards novel and more effective anti-cancer therapies.

E-pub date: 31 May 2016


The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

E-pub date: 10 May 2016


Facilitating a culture of responsible and effective sharing of cancer genome data.

E-pub date: 05 May 2016


MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.

E-pub date: 12 Apr 2016


Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays.

E-pub date: 31 Mar 2016


Cell-free circulating tumour DNA as a liquid biopsy in breast cancer.

E-pub date: 31 Mar 2016


Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.

E-pub date: 16 Feb 2016


Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

E-pub date: 01 Feb 2016


Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

E-pub date: 05 Jan 2016


Expression of androgen receptor splice variants in clinical breast cancers.

E-pub date: 29 Dec 2015


A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities.

E-pub date: 29 Dec 2015


Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

E-pub date: 22 Dec 2015


Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

E-pub date: 04 Nov 2015


BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.

E-pub date: 31 Oct 2015


APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

E-pub date: 06 Oct 2015


Pathway-based personalized analysis of breast cancer expression data.

E-pub date: 31 Aug 2015


Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

E-pub date: 31 Aug 2015


Toward understanding and exploiting tumor heterogeneity.

E-pub date: 31 Aug 2015


Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium.

E-pub date: 31 Aug 2015


Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer.

E-pub date: 28 Aug 2015


Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts.

E-pub date: 01 Aug 2015


PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes.

E-pub date: 31 Jul 2015


Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer.

E-pub date: 31 Jul 2015


Progesterone receptor modulates ERα action in breast cancer.

E-pub date: 16 Jul 2015


Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel–response.

E-pub date: 01 Jul 2015


Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations.

E-pub date: 04 Jun 2015


Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

E-pub date: 01 Jun 2015


Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

E-pub date: 01 Jun 2015


Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial.

E-pub date: 01 Jun 2015


Identification of novel genetic markers of breast cancer survival.

E-pub date: 31 May 2015


Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also.

E-pub date: 20 May 2015


Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.

E-pub date: 23 Apr 2015


Common germline polymorphisms associated with breast cancer-specific survival.

E-pub date: 22 Apr 2015


Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond.

E-pub date: 01 Apr 2015


Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.

E-pub date: 31 Mar 2015


Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.

E-pub date: 31 Mar 2015


Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer.

E-pub date: 31 Mar 2015


Prognostic and predictive value of PDL1 expression in breast cancer.

E-pub date: 10 Mar 2015


Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

E-pub date: 19 Feb 2015


A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

E-pub date: 31 Jan 2015


Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.

E-pub date: 31 Jan 2015


Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.

E-pub date: 31 Jan 2015


The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.

E-pub date: 22 Jan 2015


Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.

E-pub date: 20 Jan 2015


A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

E-pub date: 09 Jan 2015


BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.

E-pub date: 09 Jan 2015


eEF2K–a new target in breast cancers with combined inactivation of p53 and PTEN.

E-pub date: 31 Dec 2014


Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer.

E-pub date: 03 Dec 2014


Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

E-pub date: 01 Nov 2014


Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge.

E-pub date: 01 Nov 2014


Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.

E-pub date: 31 Oct 2014


Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

E-pub date: 23 Sep 2014


Patient-derived xenograft models: an emerging platform for translational cancer research.

E-pub date: 01 Sep 2014


Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

E-pub date: 31 Aug 2014


Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients.

E-pub date: 31 Aug 2014


Genome-driven integrated classification of breast cancer validated in over 7,500 samples.

E-pub date: 28 Aug 2014


Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

E-pub date: 01 Aug 2014


The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study.

E-pub date: 31 Jul 2014


Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance.

E-pub date: 31 Jul 2014


Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.

E-pub date: 15 Jul 2014


TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

E-pub date: 01 Jul 2014


JARID1B is a luminal lineage-driving oncogene in breast cancer.

E-pub date: 16 Jun 2014


DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts.

E-pub date: 31 May 2014


Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.

E-pub date: 01 May 2014


Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

E-pub date: 28 Apr 2014


Processed pseudogenes acquired somatically during cancer development.

E-pub date: 09 Apr 2014


Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data.

E-pub date: 01 Apr 2014


The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

E-pub date: 06 Mar 2014


Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3 trial.

E-pub date: 01 Feb 2014


Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression.

E-pub date: 31 Jan 2014


A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett’s esophagus.

E-pub date: 31 Dec 2013


Assessing excellence in translational cancer research: a consensus based framework.

E-pub date: 29 Oct 2013


Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial.

E-pub date: 15 Sep 2013


TOX3 mutations in breast cancer.

E-pub date: 31 Aug 2013


Master regulators of FGFR2 signalling and breast cancer risk.

E-pub date: 31 Aug 2013


Finding common regions of alteration in copy number data.

E-pub date: 31 Aug 2013


Improving breast cancer survival analysis through competition-based multidimensional modeling.

E-pub date: 31 Aug 2013


Basic cancer research is essential for the success of personalised medicine.

E-pub date: 31 Aug 2013


A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.

E-pub date: 31 Aug 2013


Signatures of mutational processes in human cancer.

E-pub date: 22 Aug 2013


Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA.

E-pub date: 08 Aug 2013


Circulating tumor DNA to monitor metastatic breast cancer.

E-pub date: 04 Jul 2013


G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

E-pub date: 03 Jul 2013


Multidisciplinary decisions in breast cancer: does the patient receive what the team has recommended?

E-pub date: 25 Jun 2013


Genetic heterogeneity in breast cancer: the road to personalized medicine?

E-pub date: 18 Jun 2013


Video Q&A: molecular profiling of breast cancer.

E-pub date: 18 Jun 2013


The shaping and functional consequences of the microRNA landscape in breast cancer.

E-pub date: 16 May 2013


Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.

E-pub date: 02 May 2013


A metadata-aware application for remote scoring and exchange of tissue microarray images.

E-pub date: 01 May 2013


Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.

E-pub date: 17 Apr 2013


Breast cancer: Tamoxifen–when more might be better.

E-pub date: 31 Mar 2013


Analysis of circulating tumor DNA to monitor metastatic breast cancer.

E-pub date: 28 Mar 2013


A new genome-driven integrated classification of breast cancer and its implications.

E-pub date: 06 Mar 2013


A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial.

E-pub date: 05 Mar 2013


The implications of clonal genome evolution for cancer medicine.

E-pub date: 28 Feb 2013


Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

E-pub date: 21 Feb 2013


Astronomical algorithms for automated analysis of tissue protein expression in breast cancer.

E-pub date: 19 Feb 2013


Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer.

E-pub date: 31 Jan 2013


Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.

E-pub date: 22 Dec 2012


DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer.

E-pub date: 22 Dec 2012


Copynumber: Efficient algorithms for single- and multi-track copy number segmentation.

E-pub date: 04 Nov 2012


TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.

E-pub date: 01 Nov 2012


Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

E-pub date: 31 Oct 2012


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.

E-pub date: 24 Oct 2012


Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.

E-pub date: 22 Oct 2012


Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.

E-pub date: 30 Sep 2012


Calling sample mix-ups in cancer population studies.

E-pub date: 31 Aug 2012


TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer.

E-pub date: 31 Aug 2012


Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients.

E-pub date: 22 Aug 2012


Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue.

E-pub date: 31 Jul 2012


Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

E-pub date: 30 May 2012


Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping.

E-pub date: 30 May 2012


Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer.

E-pub date: 22 May 2012


The landscape of cancer genes and mutational processes in breast cancer.

E-pub date: 16 May 2012


Cancer sequencing unravels clonal evolution.

E-pub date: 07 May 2012


The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

E-pub date: 18 Apr 2012


Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers.

E-pub date: 18 Apr 2012


The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

E-pub date: 04 Apr 2012


A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer.

E-pub date: 31 Jan 2012


Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.

E-pub date: 04 Jan 2012


The breast cancer genome–a key for better oncology.

E-pub date: 30 Nov 2011


Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma.

E-pub date: 31 Oct 2011


Calpastatin is associated with lymphovascular invasion in breast cancer.

E-pub date: 31 Oct 2011


Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance.

E-pub date: 31 Aug 2011


Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.

E-pub date: 15 Aug 2011


RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype.

E-pub date: 31 Jul 2011


CYP2D6 gene variants and their association with breast cancer susceptibility.

E-pub date: 01 Jun 2011


A population-based validation of the prognostic model PREDICT for early breast cancer.

E-pub date: 31 May 2011


ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

E-pub date: 31 Mar 2011


Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer.

E-pub date: 15 Feb 2011


A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia.

E-pub date: 31 Dec 2010


Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules.

E-pub date: 04 Nov 2010


Genetics: How to validate a breast cancer prognostic signature.

E-pub date: 01 Nov 2010


From genomic landscapes to personalized cancer management-is there a roadmap?

E-pub date: 31 Oct 2010


The importance of platform annotation in interpreting microarray data.

E-pub date: 31 Aug 2010


PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer.

E-pub date: 31 Aug 2010


CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen.

E-pub date: 31 Aug 2010


Prognostic gene network modules in breast cancer hold promise.

E-pub date: 31 Aug 2010


PathGrid: a service-orientated architecture for microscopy image analysis.

E-pub date: 28 Aug 2010


Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research.

E-pub date: 31 Jul 2010


Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.

E-pub date: 30 Jun 2010


Fine scale mapping of the breast cancer 16q12 locus.

E-pub date: 15 Jun 2010


Genetic predisposition to gastro-oesophageal cancer.

E-pub date: 01 Jun 2010


Micro-RNAs and breast cancer.

E-pub date: 01 Jun 2010


Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.

E-pub date: 31 May 2010


Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression.

E-pub date: 31 May 2010


The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.

E-pub date: 31 May 2010


Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas.

E-pub date: 31 May 2010


Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.

E-pub date: 25 May 2010


International network of cancer genome projects.

E-pub date: 15 Apr 2010


Common germ-line polymorphism of C1QA and breast cancer survival.

E-pub date: 13 Apr 2010


Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).

E-pub date: 31 Mar 2010


Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

E-pub date: 01 Mar 2010


The pitfalls of platform comparison: DNA copy number array technologies assessed.

E-pub date: 08 Dec 2009


Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

E-pub date: 01 Dec 2009


A metadata approach for clinical data management in translational genomics studies in breast cancer.

E-pub date: 30 Nov 2009


Characterisation of microRNA expression in post-natal mouse mammary gland development.

E-pub date: 20 Nov 2009


The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

E-pub date: 19 Nov 2009


Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival.

E-pub date: 20 Oct 2009


Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.

E-pub date: 08 Oct 2009


Tamoxifen: the drug that came in from the cold.

E-pub date: 15 Sep 2009


Triple negative breast cancers: clinical and prognostic implications.

E-pub date: 01 Sep 2009


Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.

E-pub date: 31 Aug 2009


The breast cancer somatic ‘muta-ome’: tackling the complexity.

E-pub date: 31 Aug 2009


Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

E-pub date: 31 Aug 2009


One-stop diagnostic breast clinics: how often are breast cancers missed?

E-pub date: 16 Jun 2009


Molecular classification of solid tumours: towards pathway-driven therapeutics.

E-pub date: 19 May 2009


Germline CDH1 deletions in hereditary diffuse gastric cancer families.

E-pub date: 01 May 2009


Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells.

E-pub date: 01 Feb 2009


DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.

E-pub date: 31 Dec 2008


Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).

E-pub date: 01 Nov 2008


Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk.

E-pub date: 01 Nov 2008


Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer.

E-pub date: 01 Nov 2008


High-resolution array CGH clarifies events occurring on 8p in carcinogenesis.

E-pub date: 07 Oct 2008


PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes.

E-pub date: 31 Aug 2008


Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.

E-pub date: 31 Aug 2008


Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients.

E-pub date: 31 Aug 2008


A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer.

E-pub date: 31 Aug 2008


A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer.

E-pub date: 31 Aug 2008


ESR1 gene amplification in breast cancer: a common phenomenon?

E-pub date: 31 Jul 2008


Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer.

E-pub date: 29 May 2008


Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.

E-pub date: 06 May 2008


High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.

E-pub date: 01 May 2008


Array comparative genomic hybridization copy number profiling: a new tool for translational research in solid malignancies.

E-pub date: 01 Apr 2008


MicroRNA: implications for cancer.

E-pub date: 31 Jan 2008


Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line.

E-pub date: 15 Jan 2008


The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel.

E-pub date: 31 Dec 2007


Regulation of p53 tetramerization and nuclear export by ARC.

E-pub date: 26 Dec 2007


Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis.

E-pub date: 31 Oct 2007


p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing.

E-pub date: 18 Oct 2007


Elucidating the altered transcriptional programs in breast cancer using independent component analysis.

E-pub date: 31 Aug 2007


MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.

E-pub date: 31 Aug 2007


High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.

E-pub date: 31 Aug 2007


An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer.

E-pub date: 31 Aug 2007


Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.

E-pub date: 20 Jul 2007


BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines.

E-pub date: 15 Jul 2007


Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.

E-pub date: 31 May 2007


Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST).

E-pub date: 31 May 2007


Cancer genetics of epigenetic genes.

E-pub date: 15 Apr 2007


Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

E-pub date: 22 Mar 2007


Cross-platform array comparative genomic hybridization meta-analysis separates hematopoietic and mesenchymal from epithelial tumors.

E-pub date: 01 Mar 2007


A gene-expression signature to predict survival in breast cancer across independent data sets.

E-pub date: 01 Mar 2007


Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.

E-pub date: 15 Feb 2007


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