Authors:
M Köbel, MS Anglesio, JD Brenton
Journal name: 
J Pathol Clin Res
Citation info: 
4(3):149-153
Abstract: 
Detecting mutations in single cells from cancer specimens is now a major area of translational research. In a recent article in this journal, Khalique et al validated an immunohistochemistry assay for ARID1A that reliably identifies loss of function mutations in single cells in tissue sections. This work exemplifies best practice for developing and orthogonally validating immunohistochemical assays to provide clearly interpretable mutational results with spatial context.
DOI: 
http://doi.org/10.1002/cjp2.108
Research group: 
Brenton Group
E-pub date: 
01 Jul 2018