A Molaro, I Falciatori, E Hodges, AA Aravin, K Marran, S Rafii, WR McCombie, AD Smith, GJ Hannon
Journal name: 
Genes Dev
Citation info: 
During development, mammalian germ cells reprogram their epigenomes via a genome-wide erasure and de novo rewriting of DNA methylation marks. We know little of how methylation patterns are specifically determined. The piRNA pathway is thought to target the bulk of retrotransposon methylation. Here we show that most retrotransposon sequences are modified by default de novo methylation. However, potentially active retrotransposon copies evade this initial wave, likely mimicking features of protein-coding genes. These elements remain transcriptionally active and become targets of piRNA-mediated methylation. Thus, we posit that these two waves play essential roles in resetting germ cell epigenomes at each generation.
Research group: 
Hannon Group
E-pub date: 
15 Jul 2014
Users with this publication listed: 
Greg Hannon
Ilaria Falciatori