Authors:
RJ Gilbertson, DH Gutmann
Journal name: 
Cancer Res
Citation info: 
67(12):5579-5582
Abstract: 
Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.
DOI: 
http://doi.org/10.1158/0008-5472.CAN-07-0760
Research group: 
Gilbertson Group
E-pub date: 
15 Jun 2007