Authors:
KA Holmes, A Hurtado, GD Brown, R Launchbury, CS Ross-Innes, J Hadfield, DT Odom, JS Carroll
Journal name: 
Proc Natl Acad Sci U S A
Citation info: 
109(8):2748-2753
Abstract: 
Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin interactions, a role that is distinct from its general role as a transcriptional repressor. We show that specific silencing of TLE1 inhibits the ability of ER to bind to a subset of ER binding sites within the genome, a phenomenon that results in perturbations in phospho-RNA Pol II recruitment. Furthermore, TLE1 is essential for effective ER-mediated cell division. We have discovered a distinct role for TLE1, as a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions.
DOI: 
http://doi.org/10.1073/pnas.1018863108
Research group: 
Odom Group, Carroll Group
E-pub date: 
21 Feb 2012