Authors:
JED Thaventhiran, DT Fearon, L Gattinoni
Journal name: 
Curr Opin Immunol
Citation info: 
25(3):321-328
Abstract: 
Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.
DOI: 
http://doi.org/10.1016/j.coi.2013.05.010
E-pub date: 
01 Jun 2013