Authors:
DT Odom, RD Dowell, ES Jacobsen, W Gordon, TW Danford, KD MacIsaac, PA Rolfe, CM Conboy, DK Gifford, E Fraenkel
Journal name: 
Nat Genet
Citation info: 
39(6):730-732
Abstract: 
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.
DOI: 
http://doi.org/10.1038/ng2047
Research group: 
Odom Group
E-pub date: 
01 Jun 2007