Authors:
S Blanco, A Kurowski, J Nichols, FM Watt, SA Benitah, M Frye
Journal name: 
PLoS Genet
Citation info: 
7(12):e1002403
Abstract: 
Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.
DOI: 
http://doi.org/10.1371/journal.pgen.1002403
Research group: 
Watt Group
E-pub date: 
01 Dec 2011