Authors:
R Ahmed, MJ Bevan, SL Reiner, DT Fearon
Journal name: 
Nat Rev Immunol
Citation info: 
9(9):662-668
Abstract: 
The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.
DOI: 
http://doi.org/10.1038/nri2619
E-pub date: 
01 Sep 2009