Authors:
RJ Jackson, MT Howell, A Kaminski
Journal name: 
Trends Biochem Sci
Citation info: 
15(12):477-483
Abstract: 
The initiation of translation of picornaviral RNAs takes place by an unusual mechanism whereby ribosomes bind directly to an internal site rather than scan the RNA from the 5'-end. This internal entry mechanism requires a 450-nucleotide segment of the picornavirus 5'-untranslated region. The ribosome binds initially to a site at the 3'-end of this segment, and then may scan the RNA to reach the authentic initiation site. This novel mechanism may be of relevance to the translation of some cellular mRNAs.
DOI: 
http://doi.org/10.1016/0968-0004(90)90302-r
Research group: 
Scientific Administration
E-pub date: 
01 Dec 1990
Users with this publication listed: 
Ann Kaminski