Authors:
S Martinez Cuesta, N Furnham, SA Rahman, I Sillitoe, JM Thornton
Journal name: 
Curr Opin Struct Biol
Citation info: 
26:121-130
Abstract: 
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
DOI: 
http://doi.org/10.1016/j.sbi.2014.06.002
E-pub date: 
01 Jun 2014