Authors:
M Sibilia, A Fleischmann, A Behrens, L Stingl, J Carroll, FM Watt, J Schlessinger, EF Wagner
Journal name: 
Cell
Citation info: 
102(2):211-220
Abstract: 
The EGF receptor (EGFR) is required for skin development and is implicated in epithelial tumor formation. Transgenic mice expressing a dominant form of Son of Sevenless (SOS-F) in basal keratinocytes develop skin papillomas with 100% penetrance. However, tumor formation is inhibited in a hypomorphic (wa2) and null EGFR background. Similarly, EGFR-deficient fibroblasts are resistant to transformation by SOS-F and rasV12, however, tumorigenicity is restored by expression of the anti-apoptotic bcl-2 gene. The K5-SOS-F papillomas and primary keratinocytesfrom wa2 mice display increased apoptosis, reduced Akt phosphorylation and grafting experiments imply a cell-autonomous requirement for EGFR in keratinocytes. Therefore, EGFR functions as a survival factor in oncogenic transformation and provides a valuable target for therapeutic intervention in a broader range of tumors than anticipated.
DOI: 
http://doi.org/10.1016/s0092-8674(00)00026-x
E-pub date: 
30 Jun 2000
Users with this publication listed: 
Fiona Watt