Authors:
DT Fearon
Journal name: 
Curr Opin Immunol
Citation info: 
5(3):341-348
Abstract: 
A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.
DOI: 
http://doi.org/10.1016/0952-7915(93)90051-s
E-pub date: 
01 Jun 1993
Users with this publication listed: 
Doug Fearon