Authors:
S Balasubramanian, LH Hurley, S Neidle
Journal name: 
Nat Rev Drug Discov
Citation info: 
10(4):261-275
Abstract: 
G-quadruplexes are four-stranded DNA structures that are over-represented in gene promoter regions and are viewed as emerging therapeutic targets in oncology, as transcriptional repression of oncogenes through stabilization of these structures could be a novel anticancer strategy. Many gene promoter G-quadruplexes have physicochemical properties and structural characteristics that might make them druggable, and their structural diversity suggests that a high degree of selectivity might be possible. Here, we describe the evidence for G-quadruplexes in gene promoters and discuss their potential as therapeutic targets, as well as progress in the development of strategies to harness this potential through intervention with small-molecule ligands.
DOI: 
http://doi.org/10.1038/nrd3428
Research group: 
Balasubramanian Group
E-pub date: 
01 Apr 2011