HR Nasiri, NM Bell, KIE McLuckie, J Husby, C Abell, S Neidle, S Balasubramanian
Journal name: 
Chem Commun (Camb)
Citation info: 
We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.
Research group: 
Balasubramanian Group
E-pub date: 
18 Feb 2014
Users with this publication listed: 
Shankar Balasubramanian