Authors:
HR Nasiri, NM Bell, KIE McLuckie, J Husby, C Abell, S Neidle, S Balasubramanian
Journal name: 
Chem Commun (Camb)
Citation info: 
50(14):1704-1707
Abstract: 
We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.
DOI: 
http://doi.org/10.1039/c3cc48390h
Research group: 
Balasubramanian Group
E-pub date: 
18 Feb 2014