Authors:
F Kawasaki, P Murat, Z Li, T Santner, S Balasubramanian
Journal name: 
Chem Commun (Camb)
Citation info: 
53(8):1389-1392
Abstract: 
We report the synthesis of a 5-formyl-2'-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.
DOI: 
http://doi.org/10.1039/c6cc08670e
Research group: 
Balasubramanian Group
E-pub date: 
24 Jan 2017