Authors:
R Reljic, SD Wagner, LJ Peakman, DT Fearon
Journal name: 
J Exp Med
Citation info: 
192(12):1841-1848
Abstract: 
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether arrest of terminal differentiation can be mediated by BCL-6, a transcriptional repressor that is expressed by germinal center B cells and is required for this phase of B cell development. We find that BCL-6 suppresses the differentiation of transformed and primary B cells to plasma cells by inhibiting the signal transducer and activator of transcription 3-dependent expression of the major regulator of plasma cell development, the B lymphocyte-induced maturation protein (Blimp-1). This function of BCL-6 as a repressor of B lymphocyte differentiation may also underlie the association between chromosomal translocations of its gene and B cell lymphomas.
DOI: 
http://doi.org/10.1084/jem.192.12.1841
E-pub date: 
30 Nov 2000
Users with this publication listed: 
Doug Fearon