Authors:
M Kraman, PJ Bambrough, JN Arnold, EW Roberts, L Magiera, JO Jones, A Gopinathan, DA Tuveson, DT Fearon
Journal name: 
Science
Citation info: 
330(6005):827-830
Abstract: 
The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein-α (FAP). We created a transgenic mouse in which FAP-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-γ and tumor necrosis factor-α. Depleting FAP-expressing cells in a subcutaneous model of pancreatic ductal adenocarcinoma also permitted immunological control of growth. Therefore, FAP-expressing cells are a nonredundant, immune-suppressive component of the tumor microenvironment.
DOI: 
http://doi.org/10.1126/science.1195300
Research group: 
Tuveson Group
E-pub date: 
05 Nov 2010