M Cano, M Ladlow, S Balasubramanian
Journal name: 
J Comb Chem
Citation info: 
A chemical stability study of the benzoin photolabile safety-catch linker (BPSC) has been carried out using a dual-linker analytical construct to establish its compatibility with a range of commonly employed solid-phase reaction conditions. As a result of this study, the dithiane-protected benzoin linker was shown to be reactive only toward strong acids and fluoride nucleophile. Furthermore, a scan of diverse functional groups thought to be unstable toward the safety-catch removal conditions has also been carried out. These data should provide assistance in future utilization of the BPSC for syntheses.
Research group: 
Balasubramanian Group
E-pub date: 
01 Jan 2002
Users with this publication listed: 
Shankar Balasubramanian