Authors:
Y Ito, M Hoare, M Narita
Journal name: 
Trends Cell Biol
Citation info: 
27(11):820-832
Abstract: 
Cellular senescence is an autonomous tumor suppressor mechanism leading to stable cell cycle arrest. Senescent cells are highly secretory, driving a range of different functions through the senescence-associated secretory phenotype (SASP). Recent findings have suggested that the composition of the SASP is dynamically and spatially regulated and that the changing composition of the SASP can determine the beneficial and detrimental aspects of the senescence program, tipping the balance to either an immunosuppressive/profibrotic environment or proinflammatory/fibrolytic state. Here, we discuss the current understanding of the temporal and spatial regulation of the SASP and the novel finding of NOTCH signaling as a regulator of SASP composition.
DOI: 
http://doi.org/10.1016/j.tcb.2017.07.004
Research group: 
Narita Group
E-pub date: 
01 Nov 2017